ES2095969T3 - Derivados de quinona. - Google Patents

Derivados de quinona.

Info

Publication number
ES2095969T3
ES2095969T3 ES92103555T ES92103555T ES2095969T3 ES 2095969 T3 ES2095969 T3 ES 2095969T3 ES 92103555 T ES92103555 T ES 92103555T ES 92103555 T ES92103555 T ES 92103555T ES 2095969 T3 ES2095969 T3 ES 2095969T3
Authority
ES
Spain
Prior art keywords
group
represented
alcoxi
quinona
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92103555T
Other languages
English (en)
Inventor
Yasushi Okamoto
Katsuya Tagami
Shigeki Hibi
Hirotoshi Numata
Tetsuya Kawahara
Naoki Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2095969T3 publication Critical patent/ES2095969T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Dental Preparations (AREA)
  • Inorganic Insulating Materials (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)

Abstract

EL OBJETO DE LA PRESENTE INVENCION ES PROPORCIONAR UN DERIVADO DE QUINONA QUE MUESTRE UNA ACTIVIDAD EXCELENTE COMO DROGA. LA PRESENTE INVENCION PROPORCIONA UN DERIVADO DE QUINONA REPRESENTADO POR LA FORMULA GENERAL *FIG* O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO: DONDE A REPRESENTA UN GRUPO REPRESENTADO POR LA FORMULA: (EN DONDE R3, R4 Y R5 SON IGUALES O DIFERENTES Y CADA UNO REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO HIDROXILO, UN GRUPO ALKILO INFERIOR, UN GRUPO ALCOXI INFERIOR, UN GRUPO ALCOXIALKILO, UN GRUPO ALCOXIALCOXI, UN GRUPO CICLOALKILALCOXI, UN GRUPO TIOL O UN GRUPO TIOLALKILO, CON LA CONDICION DE QUE SE EXCEPTUE UN CASO EN DONDE R3 Y R4 SEAN UN GRUPO ALCOXI INFERIOR SIMULTANEAMENTE) O UN GRUPO REPRESENTADO POR LA FORMULA: (EN DONDE R3, R4 Y R5 SON IGUALES O DIFERENTES Y CADA UNO REPRESENTE UN ATOMO DE HIDROGENO, UN GRUPO HIDROXILO, UN GRUPO ALKILO INFERIOR, UN GRUPO ALCOXI INFERIOR, UN GRUPO ALCOXIALKILO, UN GRUPO ALCOXIALCOXI, UN GRUPO CICLOALKILALCOXI, UN GRUPO TIOL O UNGRUPO TIOLALKILO, CON LA CONDICION DE QUE SE EXCEPTUE UN CASO EN DONDE R3 Y R4 ESTEN REPRESENTADOS SIMULTANEAMENTE POR UN GRUPO ALCOXI INFERIOR; X E Y SON IGUALES O DIFERENTES Y CADA UNO REPRESENTA UN GRUPO HIDROXILO O UN GRUPO HIDROXILO PROTEGIDO); R1 REPRESENTA UN GRUPO HETEROALKILO; Y B REPRESENTA UN GRUPO CARBOXIL O UN GRUPO CARBOXIL PROTEGIDO.
ES92103555T 1991-03-11 1992-03-02 Derivados de quinona. Expired - Lifetime ES2095969T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4470991 1991-03-11
JP17816191 1991-07-18

Publications (1)

Publication Number Publication Date
ES2095969T3 true ES2095969T3 (es) 1997-03-01

Family

ID=26384670

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92103555T Expired - Lifetime ES2095969T3 (es) 1991-03-11 1992-03-02 Derivados de quinona.

Country Status (20)

Country Link
US (1) US5329010A (es)
EP (1) EP0503426B1 (es)
JP (1) JP3310687B2 (es)
KR (1) KR950005198B1 (es)
CN (1) CN1064679A (es)
AT (1) ATE146778T1 (es)
AU (1) AU643125B2 (es)
CA (1) CA2062263A1 (es)
DE (1) DE69216124T2 (es)
DK (1) DK0503426T3 (es)
ES (1) ES2095969T3 (es)
FI (1) FI921006A7 (es)
GR (1) GR3022885T3 (es)
HU (1) HUT67036A (es)
IE (1) IE920595A1 (es)
MX (1) MX9201047A (es)
NO (1) NO178147C (es)
NZ (1) NZ241897A (es)
RU (1) RU2049776C1 (es)
TW (1) TW267165B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0949259B1 (en) 1996-12-26 2001-06-20 Nikken Chemicals Company, Limited N-hydroxyurea derivatives and medicinal compositions containing the same
DE69830929T2 (de) 1997-11-11 2006-04-20 Nikken Chemicals Co., Ltd. N-hydroxyurea-derivat und dieses enthaltende pharmazeutische zusammensetzung
US7179860B2 (en) * 2001-03-13 2007-02-20 Liwei Cao Crosslinked polymer electrolyte membranes for heat, ion and moisture exchange devices
RU2504584C2 (ru) * 2011-03-03 2014-01-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ ПИРРОЛОХИНОЛИНОХИНОНА (PQQ) С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Methylobacterium ИЛИ Hyphomicrobium
US9359275B2 (en) 2012-02-23 2016-06-07 Children's Medical Center Corporation Natural product antibiotics and analogs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58177934A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd ベンゾキノン誘導体
JPS60139646A (ja) * 1983-12-27 1985-07-24 Otsuka Pharmaceut Factory Inc ナフタレン誘導体
IL81264A (en) * 1986-01-30 1990-11-05 Takeda Chemical Industries Ltd Quinone derivatives,their production and pharmaceutical compositions containing them
FI102273B (fi) * 1989-09-11 1998-11-13 Eisai Co Ltd Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyt tö

Also Published As

Publication number Publication date
CN1064679A (zh) 1992-09-23
US5329010A (en) 1994-07-12
NO920913L (no) 1992-09-14
DE69216124T2 (de) 1997-05-22
NO920913D0 (no) 1992-03-09
JPH0578321A (ja) 1993-03-30
DK0503426T3 (da) 1997-06-09
GR3022885T3 (en) 1997-06-30
ATE146778T1 (de) 1997-01-15
NZ241897A (en) 1996-01-26
JP3310687B2 (ja) 2002-08-05
HU9200807D0 (en) 1992-05-28
CA2062263A1 (en) 1992-09-12
MX9201047A (es) 1992-09-01
KR950005198B1 (ko) 1995-05-19
TW267165B (es) 1996-01-01
KR920018025A (ko) 1992-10-21
AU1219392A (en) 1992-09-17
AU643125B2 (en) 1993-11-04
EP0503426A1 (en) 1992-09-16
FI921006A0 (fi) 1992-03-06
EP0503426B1 (en) 1996-12-27
FI921006A7 (fi) 1992-09-12
HUT67036A (en) 1995-01-30
IE920595A1 (en) 1992-09-23
NO178147C (no) 1996-01-31
DE69216124D1 (de) 1997-02-06
RU2049776C1 (ru) 1995-12-10
NO178147B (no) 1995-10-23

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