ES2096712T3 - Composiciones analgesicas. - Google Patents

Composiciones analgesicas.

Info

Publication number
ES2096712T3
ES2096712T3 ES92300987T ES92300987T ES2096712T3 ES 2096712 T3 ES2096712 T3 ES 2096712T3 ES 92300987 T ES92300987 T ES 92300987T ES 92300987 T ES92300987 T ES 92300987T ES 2096712 T3 ES2096712 T3 ES 2096712T3
Authority
ES
Spain
Prior art keywords
ibuprophen
around
weight
emulsion
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92300987T
Other languages
English (en)
Inventor
Dhiraj Shantilal Mody
Robert George Blank
Gary Robert Agasim
Gloria Yoshiko Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2096712T3 publication Critical patent/ES2096712T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA INVENCION PROPORCIONA UN COMPUESTO ANALGESICO TOPICO QUE COMPRENDE UNA EMULSION DE ACEITE EN AGUA, CONTENIENDO ALREDEDOR DE UN 5% A UN 12% POR PESO DE IBUPROFENO Y ALREDEDOR DE UN 60% A UN 90% POR PESO DE AGUA, CONSTANDO LA FASE OLEOSA DE LA EMULSION ESENCIALMENTE DE CONSTITUYENTES EMOLIENTES QUE NO DISUELVEN EL IBUPROFENO EN NINGUNA GRAN EXTENSION, CON UN PH DE 4-7, TENIENDO LA COMPOSICION UN PH DE ALREDEDOR DE UN 4 A UN 7.2, DE TAL FORMA QUE EL IBUPROFENO ESTA EN SUSPENSION EN UNA FORMA SUBSTANCIALMENTE CRISTALINA SOLIDA Y EL IBUPROFENO QUE ESTA DISUELTO ESTA EN UN ESTADO PARCIALMENTE NEUTRO O NO CARGADO. LA INVENCION TAMBIEN INCLUYE UN PROCESO PARA PREPARAR ESTE COMPUESTO.
ES92300987T 1991-02-11 1992-02-06 Composiciones analgesicas. Expired - Lifetime ES2096712T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65411791A 1991-02-11 1991-02-11
US74101191A 1991-08-06 1991-08-06
US07/814,995 US5210099A (en) 1991-02-11 1992-01-08 Analgesic compositions

Publications (1)

Publication Number Publication Date
ES2096712T3 true ES2096712T3 (es) 1997-03-16

Family

ID=27417914

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92300987T Expired - Lifetime ES2096712T3 (es) 1991-02-11 1992-02-06 Composiciones analgesicas.

Country Status (18)

Country Link
US (1) US5210099A (es)
EP (1) EP0499399B1 (es)
JP (1) JPH0558884A (es)
KR (1) KR920016087A (es)
AT (1) ATE147624T1 (es)
AU (1) AU650946B2 (es)
CA (1) CA2060833C (es)
DE (1) DE69216650T2 (es)
DK (1) DK0499399T3 (es)
ES (1) ES2096712T3 (es)
FI (1) FI100856B (es)
GR (1) GR3022886T3 (es)
IE (1) IE920245A1 (es)
MX (1) MX9200554A (es)
NO (1) NO179273C (es)
NZ (1) NZ241547A (es)
TW (1) TW225987B (es)
UY (1) UY23373A1 (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013257A1 (en) * 1992-12-16 1994-06-23 Creative Products Resource Associates, Ltd. Occlusive/semi-occlusive lotion for treatment of a skin disease or disorder
DE4405641C2 (de) * 1994-02-22 1997-04-30 Roemmers Sa Pharmazeutische Zusammensetzung, enthaltend 2-(4-Methoxyphenoxy)-3-pyridinamin
US5654337A (en) * 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
ES2118033B1 (es) * 1996-02-16 1999-07-01 Bial Ind Farmaceutica S A Formulacion farmaceutica antiinflamatoria.
US7914814B2 (en) * 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US7629384B2 (en) * 1997-09-17 2009-12-08 Strategic Science & Technologies, Llc Topical delivery of L-arginine to cause beneficial effects
US6083996A (en) * 1997-11-05 2000-07-04 Nexmed Holdings, Inc. Topical compositions for NSAI drug delivery
WO1999026571A1 (en) * 1997-11-25 1999-06-03 Theratech, Inc. Transdermal delivery devices containing polydiorganosiloxane polymers to regulate adhesive properties
US6368618B1 (en) * 1999-07-01 2002-04-09 The University Of Georgia Research Foundation, Inc. Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs
WO2003028702A1 (en) * 2001-10-04 2003-04-10 Macrochem Corporation Ibuprofen salt emulsifiers and cream formulations containing same
US20040132823A1 (en) * 2001-11-02 2004-07-08 Leo Pavliv Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid
EP1732577B1 (en) * 2004-02-23 2013-04-10 Strategic Science & Technologies, LLC Topical delivery of l-arginine to improve body and skin appearance
US20090105336A1 (en) * 2004-04-19 2009-04-23 Strategic Science & Technologies, Llc Beneficial Effects of Increasing Local Blood Flow
US20110028548A1 (en) * 2004-04-19 2011-02-03 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
JP2007532697A (ja) * 2004-04-19 2007-11-15 ストラテジック サイエンス アンド テクノロジーズ， エルエルシー 局所的血流増大の有益な効果
TW200613004A (en) * 2004-08-31 2006-05-01 Aspion Co Ltd External preparation of solid/oil type
GB2423710A (en) 2005-03-01 2006-09-06 Boots Healthcare Int Ltd Lozenge production process
US20070098660A1 (en) * 2005-10-27 2007-05-03 Jim Taneri Methods and compositions for epilation
US20080095831A1 (en) * 2006-08-10 2008-04-24 Mc Graw Thomas L Topical formulation of multilamellar vesicles composition for percutaneous absorption of pharmaceutically active agent
KR20110017365A (ko) * 2008-05-30 2011-02-21 페어필드 클리니컬 트라이얼즈 엘엘씨 피부 염증 및 변색을 위한 방법 및 조성물
BRPI0918142A2 (pt) 2008-09-10 2015-12-01 Biochemics Inc composição farmaclógica tópica, seu método de preparação, bem como uso da forma de ácido livre de ácido 2-(4-isobutifilfenil)prpiônico
MX349176B (es) 2008-09-22 2017-07-14 Biochemics Inc Suministro transdermico de farmaco empleando un osmolito y un agente vasoactivo.
GB0818473D0 (en) 2008-10-08 2008-11-12 Probio Nutraceuticals As Composition
US20100099775A1 (en) * 2008-10-17 2010-04-22 Alpharx Inc. Method for ameliorating of post-anesthetic recovery
EP2445493A1 (en) 2009-06-24 2012-05-02 Strategic Science & Technologies, LLC Topical composition containing naproxen
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
CN102481275B (zh) 2009-06-24 2014-07-23 战略科学技术有限公司 含有布洛芬的表面组合物
US12138268B2 (en) 2009-06-24 2024-11-12 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
CN103442723A (zh) 2010-12-29 2013-12-11 战略科学与技术有限责任公司 治疗变态反应和其它适应症的系统和方法
EP2658551B1 (en) 2010-12-29 2020-07-01 Strategic Science & Technologies, LLC Treatment of erectile dysfunction and other indications
US9452135B2 (en) 2012-03-20 2016-09-27 Particle Dynamics International, Llc Gelling agent-based dosage form
JP6121796B2 (ja) * 2012-05-23 2017-04-26 キユーピー株式会社 脂肪乳剤および医薬品組成物中の非ステロイド性抗炎症薬の含有量を高める方法
US10596117B1 (en) 2014-12-31 2020-03-24 Eric Morrison Lipoleosomes as carriers for aromatic amide anesthetic compounds
US10561627B2 (en) 2014-12-31 2020-02-18 Eric Morrison Ibuprofen nanoparticle carriers encapsulated with hermetic surfactant films
US11007161B1 (en) 2014-12-31 2021-05-18 Eric Morrison Ibuprofen nanoparticle carriers encapsulated with hermatic surfactant films
EP3268085A4 (en) 2015-03-13 2018-10-31 The Board of Trustees of The Leland Stanford Junior University Ltb4 inhibition to prevent and treat human lymphedema
WO2019112848A1 (en) 2017-12-04 2019-06-13 Johnson & Johnson Consumer Inc. Topical emulsion composition containing nonsteroidal anti-inflammatory drug

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2742396A (en) * 1952-08-13 1956-04-17 Purdue Research Foundation Ointment base
CA727589A (en) * 1962-12-27 1966-02-08 Braun Ernest Depilatory composition
US4385049A (en) * 1981-05-12 1983-05-24 K-V Pharmaceutical Company Stable high internal phase ratio topical emulsions
JPS5829706A (ja) * 1981-08-14 1983-02-22 Toko Yakuhin Kogyo Kk 消炎鎮痛外用剤
JPS59139315A (ja) * 1983-01-31 1984-08-10 Taisho Pharmaceut Co Ltd クリ−ム剤
DE3532562A1 (de) * 1985-09-12 1987-03-12 Dolorgiet Gmbh & Co Kg Transdermal resorbierbare, wasserhaltige zubereitungen von arylpropionsaeurederivaten und verfahren zur herstellung derselben
US5093133A (en) * 1990-01-24 1992-03-03 Mcneil-Ppc, Inc. Method for percutaneous delivery of ibuprofen using hydroalcoholic gel

Also Published As

Publication number Publication date
AU650946B2 (en) 1994-07-07
FI920523L (fi) 1992-08-12
MX9200554A (es) 1992-08-01
IE920245A1 (en) 1992-08-12
EP0499399B1 (en) 1997-01-15
NO179273C (no) 1996-09-11
NO920527L (no) 1992-08-12
NZ241547A (en) 1993-02-25
DK0499399T3 (da) 1997-02-03
TW225987B (es) 1994-07-01
DE69216650D1 (de) 1997-02-27
JPH0558884A (ja) 1993-03-09
EP0499399A1 (en) 1992-08-19
AU1073092A (en) 1992-08-13
US5210099A (en) 1993-05-11
FI100856B (fi) 1998-03-13
KR920016087A (ko) 1992-09-24
CA2060833A1 (en) 1992-08-12
UY23373A1 (es) 1992-07-23
NO179273B (no) 1996-06-03
DE69216650T2 (de) 1997-05-07
GR3022886T3 (en) 1997-06-30
FI920523A0 (fi) 1992-02-07
ATE147624T1 (de) 1997-02-15
NO920527D0 (no) 1992-02-10
CA2060833C (en) 1997-12-30

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