ES2096854T3 - Un metodo de produccion de sulfamida. - Google Patents

Un metodo de produccion de sulfamida.

Info

Publication number
ES2096854T3
ES2096854T3 ES93301235T ES93301235T ES2096854T3 ES 2096854 T3 ES2096854 T3 ES 2096854T3 ES 93301235 T ES93301235 T ES 93301235T ES 93301235 T ES93301235 T ES 93301235T ES 2096854 T3 ES2096854 T3 ES 2096854T3
Authority
ES
Spain
Prior art keywords
ring
group
sulfamide
represented
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93301235T
Other languages
English (en)
Inventor
Yuji Sendo
Makoto Kii
Yasuhiro Nishitani
Tadashi Irie
Yutaka Nishino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP4221767A external-priority patent/JP2542773B2/ja
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2096854T3 publication Critical patent/ES2096854T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L63/00—Compositions of epoxy resins; Compositions of derivatives of epoxy resins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE PRESENTA UN METODO PARA PRODUCIR UNA SULFAMIDA QUE INCLUYE LOS PASOS DE HACER REACCIONAR UN ALCOHOL Y UN COMPUESTO DE OXICARBONILSULFAMIDA EN LA PRESENCIA DE UN COMPUESTO DE FOSFORO TRIVALENTE Y UN DERIVADO DE ACIDO AZODICARBOXILICO. EN UNA CONFORMACION, LA SULFAMIDA ESTA REPRESENTADA POR LA FORMULA I, EL ALCOHOL ESTA REPRESENTADO POR LA FORMULA (II), Y EL COMPUESTO DE OXICARBONILSULFAMIDA ESTA REPRESENTADO POR LA FORMULA (III): (I) R3NHSO2NR1R2 EN DONDE R1 Y R2 SE SELECCIONAN INDEPENDIENTEMENTE ENTRE EL GRUPO QUE CONSTA DE HIDROGENO, ALQUIL, CICLOALQUIL, AQUENIL, ALQUINIL, ARALQUIL, ARIL, UN GRUPO HETEROCICLICO Y ALQUIL SUSTITUIDO CON EL GRUPO HETEROCICLICO, RESPECTIVAMENTE, DICHO GRUPO HETEROCICLICO SE SELECCIONA ENTRE EL GRUPO QUE CONSTA DE PIRANOSULFONIL, FURANOSULFONIL, PIPERIDINIL, PIRROLIDINIL, UN ANILLO DE ACETIDINONA, UN ANILLO DE CEFEM, UN ANILLO DE PENEM, UN ANILLO DE CARBAPENEM; R3 SE SELECCIONA ENTRE EL GRUPO QUE CONSTA DE ALQUIL, ALQUENIL, ALQUINIL, ARALQUIL, UN GRUPO HETEROCICLICO, ALQUIL SUSTITUIDO CON EL GRUPO HETEROCICLICO, PIRROLIDINIL-METIL, DICHO GRUPO HETEROCICLICO SE SELECCIONA ENTRE EL GRUPO QUE CONSTA DE PIRANOSIL, FURANOSIL, PIPERIDINIL, PIRROLIDINIL, UN ANILLO DE ACETIDINONA, UN ANILLO DE CEFEM, UN ANILLO DE PENEM Y UN ANILLO DE CARBAPENEM; (II) R3OH EN DONDE R3 ES COMO SE DEFINIO ANTERIORMENTE; (III) R4OOC-NHSO2NR1R2 EN DONDE R1 Y R2 SON COMO SE DEFINIERON ANTERIORMENTE; Y R4 ES UN GRUPO DE PROTECCION DE CARBOXIDO.
ES93301235T 1992-02-21 1993-02-19 Un metodo de produccion de sulfamida. Expired - Lifetime ES2096854T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3536692 1992-02-21
JP18093092 1992-07-08
JP4221767A JP2542773B2 (ja) 1991-08-20 1992-08-20 ピロリジルチオカルバペネム誘導体

Publications (1)

Publication Number Publication Date
ES2096854T3 true ES2096854T3 (es) 1997-03-16

Family

ID=27288738

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93301235T Expired - Lifetime ES2096854T3 (es) 1992-02-21 1993-02-19 Un metodo de produccion de sulfamida.

Country Status (8)

Country Link
US (1) US5539102A (es)
EP (1) EP0557122B1 (es)
CN (2) CN1222508C (es)
AT (1) ATE147726T1 (es)
DE (1) DE69307355T2 (es)
DK (1) DK0557122T3 (es)
ES (1) ES2096854T3 (es)
GR (1) GR3022542T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029913A1 (en) * 1994-05-02 1995-11-09 Shionogi & Co., Ltd. Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same
US20030153191A1 (en) 2000-03-31 2003-08-14 Izumi Saitoh Novel crystal form of pyrrolidylthiocarbapenem derivative
US6495358B1 (en) 2000-04-19 2002-12-17 Wichita State University Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
BRPI0407480A (pt) * 2003-02-14 2006-02-07 Shionogi & Co Cristal de intermediário sintético de carbapenem
EP2127650B1 (en) 2004-06-10 2018-12-05 FOB Synthesis, Inc. Carbapenem antibacterials with gram-negative activity and processes for their preparation
EP1852436A4 (en) * 2005-02-15 2010-02-24 Shionogi & Co PROCESS FOR PRODUCING CARBAPENEME DERIVATIVE AND CRYSTALLINE INTERMEDIATE THEREOF
US7932381B2 (en) * 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
CN100582106C (zh) * 2006-01-27 2010-01-20 上海医药工业研究院 一种吡咯烷硫基碳青霉烯衍生物的制备方法及其中间体
ES2653837T3 (es) 2010-06-18 2018-02-09 Fob Synthesis, Inc. Antibacterianos carbapenem con actividad gramo-negativa
CN117383994B (zh) * 2023-09-27 2026-03-31 内蒙古工业大学 一种不对称脲类化合物的制备方法及不对称脲类化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050927B1 (en) * 1980-10-25 1985-03-27 Beecham Group Plc The preparation of beta-lactam antibiotics

Also Published As

Publication number Publication date
EP0557122A1 (en) 1993-08-25
CN1078718A (zh) 1993-11-24
CN1222508C (zh) 2005-10-12
ATE147726T1 (de) 1997-02-15
CN1052474C (zh) 2000-05-17
EP0557122B1 (en) 1997-01-15
US5539102A (en) 1996-07-23
CN1257068A (zh) 2000-06-21
GR3022542T3 (en) 1997-05-31
DE69307355D1 (de) 1997-02-27
DE69307355T2 (de) 1997-05-15
DK0557122T3 (da) 1997-02-03

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