ES2097120T3 - Estabilizacion de proteinas altamente purificadas. - Google Patents

Estabilizacion de proteinas altamente purificadas.

Info

Publication number
ES2097120T3
ES2097120T3 ES90113210T ES90113210T ES2097120T3 ES 2097120 T3 ES2097120 T3 ES 2097120T3 ES 90113210 T ES90113210 T ES 90113210T ES 90113210 T ES90113210 T ES 90113210T ES 2097120 T3 ES2097120 T3 ES 2097120T3
Authority
ES
Spain
Prior art keywords
protein
stabilization
highly purified
purified proteins
carbohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90113210T
Other languages
English (en)
Inventor
Michael H Coan
Vivian W Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23517903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2097120(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of ES2097120T3 publication Critical patent/ES2097120T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN CARBOHIDRATO, TAL COMO MANITOL O DEXTRAN-70 SE AÑADE DURANTE LA PURIFICACION DE UNA PROTEINA, TAL COMO EL FACTOR VIII:C. EL CARBOHIDRATO ESTABILIZA LA PROTEINA, INCLUSO CUANDO LA PROTEINA SE ENCUENTRA ENTRE EL 60 Y 99% DE PUEREZA. EL CARBOHIDRATO SE AÑADE A TRAVES DE VARIOS PASOS DE PURIFICACION Y ESTA PRESENTE EN EL ENVASE FINAL PARA, DE ESTA FORMA, ESTABILIZAR LA PROTEINA DURANTE SU CONGELACION EN SECO Y SU RECONSTITUCION.
ES90113210T 1989-07-24 1990-07-11 Estabilizacion de proteinas altamente purificadas. Expired - Lifetime ES2097120T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38458489A 1989-07-24 1989-07-24

Publications (1)

Publication Number Publication Date
ES2097120T3 true ES2097120T3 (es) 1997-04-01

Family

ID=23517903

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90113210T Expired - Lifetime ES2097120T3 (es) 1989-07-24 1990-07-11 Estabilizacion de proteinas altamente purificadas.

Country Status (8)

Country Link
EP (1) EP0410207B1 (es)
JP (1) JPH0358998A (es)
AT (1) ATE148165T1 (es)
CA (1) CA2021452A1 (es)
DE (1) DE69029765T2 (es)
DK (1) DK0410207T3 (es)
ES (1) ES2097120T3 (es)
GR (1) GR3022614T3 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165467A (en) * 1991-07-20 2000-12-26 Yoshihide Hagiwara Stabilized human monoclonal antibody preparation
JP2966592B2 (ja) * 1991-07-20 1999-10-25 萩原 義秀 安定化されたヒトモノクローナル抗体製剤
US6270723B1 (en) * 1998-06-15 2001-08-07 Bbi Bioseq, Inc. Rapid cryobaric sterilization and vaccine preparation
CA2634663C (en) 1999-02-22 2009-08-25 University Of Connecticut Novel albumin-free factor viii formulations
DE60041363D1 (de) 1999-07-14 2009-02-26 Spectral Diagnostics Inc Präparierung von sphären für diagnostische tests
HU228583B1 (en) 2000-11-07 2013-04-29 Novartis Vaccines & Diagnostic Stabilized interferon compositions
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
DE60215823T2 (de) * 2001-08-07 2007-09-06 Novozymes A/S Kohlhydrate und polyole zum lösen der proteinkristalle
KR20030060660A (ko) * 2002-01-10 2003-07-16 손정일 앞/뒷면 구별 없는 양면 양말
WO2004007520A2 (en) * 2002-07-12 2004-01-22 Medarex, Inc. Methods and compositions for preventing oxidative degradation of proteins
JP2008501639A (ja) * 2004-04-23 2008-01-24 ノベシン リミテッド タンパク質を安定化、保護及び可溶化させるための方法及びキット
AU2005235800B2 (en) * 2004-04-23 2011-08-04 Expedeon Limited Methods and kits for stabilising, protecting and solubilising proteins
CN101605532A (zh) * 2007-02-16 2009-12-16 惠氏公司 含有山梨糖醇的蛋白质调配物
WO2009140162A1 (en) * 2008-05-15 2009-11-19 Baxter International Inc. Stable pharmaceutical formulations
EP2385825B1 (en) 2008-11-07 2018-10-10 University of Connecticut Factor viii formulations
CN103269716B (zh) 2010-12-02 2015-05-27 昂科利蒂克斯生物科技公司 冻干病毒制剂
WO2012075379A2 (en) 2010-12-02 2012-06-07 Oncolytics Biotech Inc. Liquid viral formulations
MX337348B (es) * 2011-04-29 2016-02-29 Oncolytics Biotech Inc Metodos para purificar virus utilizando cromatografia de permeacion en gel.
JP6516829B2 (ja) 2014-08-04 2019-05-22 シーエスエル、リミテッド 第ｖｉｉｉ因子製剤
KR20220029733A (ko) 2019-07-04 2022-03-08 체에스엘 베링 렝나우 아게 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf)
EP4240757A2 (en) 2020-11-09 2023-09-13 Takeda Pharmaceutical Company Limited Purification of fviii from plasma using silicon oxide adsorption

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
CA1329760C (en) * 1987-10-29 1994-05-24 Ted C. K. Lee Plasma and recombinant protein formulations in high ionic strength media

Also Published As

Publication number Publication date
GR3022614T3 (en) 1997-05-31
JPH0358998A (ja) 1991-03-14
DE69029765T2 (de) 1997-05-15
EP0410207B1 (en) 1997-01-22
CA2021452A1 (en) 1991-01-25
DK0410207T3 (da) 1997-07-14
EP0410207A3 (en) 1992-01-15
ATE148165T1 (de) 1997-02-15
EP0410207A2 (en) 1991-01-30
DE69029765D1 (de) 1997-03-06

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