ES2097548T3 - Suspensiones estables de microburbujas como agentes de intensificacion para ecografia ultrasonica. - Google Patents

Suspensiones estables de microburbujas como agentes de intensificacion para ecografia ultrasonica.

Info

Publication number
ES2097548T3
ES2097548T3 ES93923522T ES93923522T ES2097548T3 ES 2097548 T3 ES2097548 T3 ES 2097548T3 ES 93923522 T ES93923522 T ES 93923522T ES 93923522 T ES93923522 T ES 93923522T ES 2097548 T3 ES2097548 T3 ES 2097548T3
Authority
ES
Spain
Prior art keywords
microbubbles
intensification
agents
ultrasonic echography
suspensions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93923522T
Other languages
English (en)
Inventor
Michel Schneider
Jean Brochot
Jerome Puginier
Feng Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8212014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2097548(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of ES2097548T3 publication Critical patent/ES2097548T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Aeration Devices For Treatment Of Activated Polluted Sludge (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Physical Water Treatments (AREA)
  • Surgical Instruments (AREA)
  • Amplifiers (AREA)
  • Colloid Chemistry (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)
  • Cosmetics (AREA)

Abstract

SE PRESENTAN SUSPENSIONES INYECTABLES DE MICROBURBUJAS LLENAS DE GAS, EN UN LIQUIDO PORTADOR ACUOSO, QUE SE USA COMO AGENTE DE CONTRASTE EN ECOGRAFIA ULTRASONICA. LAS SUSPENSIONES COMPRENDEN COMPUESTOS ANFIPATICOS DE LOS QUE AL MENOS UNO PUEDE SER UN FOSFOLIPIDO LAMINARIZADO COMO UN ESTABILIZADOR DE LAS MICROBURBUJAS, CONTRA EL COLAPSO CON TIEMPO Y PRESION. LA CONCENTRACION DE FOSFOLIPIDOS EN EL LIQUIDO PORTADOR ESTA POR DEBAJO DE 0''01% POR PESO, PERO ES AL MENOS IGUAL, O SUPERIOR, A LA QUE SE PRESENTAN AISLADAMENTE MOLECULAS FOSFOLIPIDAS EN EL ACOPLAMIENTO LIQUIDOMICROBURBUJAS DE GAS. TAMBIEN SE PRESENTA UNA PREPARACION DE LAS SUSPENSIONES ESTABLES DE MICROBURBUJAS LLENAS DE AIRE O GAS.
ES93923522T 1992-11-02 1993-10-21 Suspensiones estables de microburbujas como agentes de intensificacion para ecografia ultrasonica. Expired - Lifetime ES2097548T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92810837 1992-11-02

Publications (1)

Publication Number Publication Date
ES2097548T3 true ES2097548T3 (es) 1997-04-01

Family

ID=8212014

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93923522T Expired - Lifetime ES2097548T3 (es) 1992-11-02 1993-10-21 Suspensiones estables de microburbujas como agentes de intensificacion para ecografia ultrasonica.

Country Status (22)

Country Link
US (7) US5445813A (es)
EP (1) EP0619743B1 (es)
JP (1) JP3135919B2 (es)
KR (1) KR100216138B1 (es)
CN (1) CN1069838C (es)
AT (1) ATE146972T1 (es)
AU (3) AU666238B2 (es)
CA (1) CA2125027C (es)
DE (2) DE69307124T2 (es)
DK (1) DK0619743T3 (es)
ES (1) ES2097548T3 (es)
FI (1) FI115953B (es)
GR (1) GR3022826T3 (es)
HU (1) HU227043B1 (es)
IL (1) IL107453A (es)
IS (1) IS1625B (es)
LU (1) LU90837I2 (es)
NL (1) NL300061I2 (es)
NO (1) NO308830B1 (es)
NZ (2) NZ257115A (es)
WO (1) WO1994009829A1 (es)
ZA (1) ZA938117B (es)

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US5597549A (en) 1997-01-28
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