ES2099273T3 - Comprimidos de verapamil de liberacion controlada. - Google Patents
Comprimidos de verapamil de liberacion controlada.Info
- Publication number
- ES2099273T3 ES2099273T3 ES92916803T ES92916803T ES2099273T3 ES 2099273 T3 ES2099273 T3 ES 2099273T3 ES 92916803 T ES92916803 T ES 92916803T ES 92916803 T ES92916803 T ES 92916803T ES 2099273 T3 ES2099273 T3 ES 2099273T3
- Authority
- ES
- Spain
- Prior art keywords
- controlled release
- tablets
- release verapamil
- verapamil tablets
- rubber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000013270 controlled release Methods 0.000 title abstract 2
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 title 1
- 229960001722 verapamil Drugs 0.000 title 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Cephalosporin Compounds (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Separation By Low-Temperature Treatments (AREA)
- External Artificial Organs (AREA)
Abstract
SE PRESENTAN TABLETAS DE VARAPAMIL DE LIBERACION CONTROLADA. LAS TABLETAS INCLUYEN UN EXCIPIENTE QUE TIENE UN MATERIAL HIDROFILICO, QUE PREFERIBLEMENTE CONTIENE UNA MEZCLA DE GOMA XANTANO/GOMA DE ALGARROBA Y UN DILUYENTE INERTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/736,031 US5169639A (en) | 1988-09-19 | 1991-07-25 | Controlled release verapamil tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2099273T3 true ES2099273T3 (es) | 1997-05-16 |
Family
ID=24958214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92916803T Expired - Lifetime ES2099273T3 (es) | 1991-07-25 | 1992-07-02 | Comprimidos de verapamil de liberacion controlada. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5169639A (es) |
| EP (1) | EP0550737B1 (es) |
| JP (1) | JPH0733339B2 (es) |
| KR (1) | KR0184308B1 (es) |
| AT (1) | ATE147974T1 (es) |
| AU (1) | AU649163B2 (es) |
| CA (1) | CA2092287C (es) |
| DE (1) | DE69217031T2 (es) |
| DK (1) | DK0550737T3 (es) |
| ES (1) | ES2099273T3 (es) |
| FI (1) | FI107231B (es) |
| GR (1) | GR3023086T3 (es) |
| HU (1) | HU218658B (es) |
| IE (1) | IE922411A1 (es) |
| IL (1) | IL102614A (es) |
| MX (1) | MX9204352A (es) |
| WO (1) | WO1993001803A1 (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472711A (en) * | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| US5993860A (en) * | 1993-06-17 | 1999-11-30 | Venture Lending | NSADI delivery employing a powdered hydrocolloid gum obtainable from higher plants |
| JP2527132B2 (ja) * | 1993-08-25 | 1996-08-21 | 清水化学株式会社 | 親水性多糖類よりなる外用薬組成物 |
| US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US6726930B1 (en) * | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
| US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
| US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US5399358A (en) * | 1993-11-12 | 1995-03-21 | Edward Mendell Co., Inc. | Sustained release formulations for 24 hour release of metroprolol |
| US5399359A (en) * | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
| US5399362A (en) * | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| JP3279318B2 (ja) * | 1994-04-25 | 2002-04-30 | ペンウェスト ファーマシューティカルズ カンパニー | 持続放出性賦形剤 |
| WO1996012477A1 (en) * | 1994-10-21 | 1996-05-02 | Leiras Oy | Controlled release oral delivery system containing oxybutynin |
| WO1996016638A1 (en) * | 1994-12-01 | 1996-06-06 | Cibus Pharmaceutical, Inc. | Sustained-release drug delivery employing a powdered hydrocolloid gum obtainable from higher plants |
| FR2729857B1 (fr) | 1995-01-27 | 1997-04-04 | Rhone Poulenc Chimie | Compositions pharmaceutiques sous forme de comprimes a liberation prolongee a base de granules en polysaccharides de haut poids moleculaire |
| US6083532A (en) * | 1995-03-01 | 2000-07-04 | Duramed Pharmaceuticals, Inc. | Sustained release formulation containing three different types of polymers and tablet formed therefrom |
| US5695781A (en) * | 1995-03-01 | 1997-12-09 | Hallmark Pharmaceuticals, Inc. | Sustained release formulation containing three different types of polymers |
| AU2068797A (en) * | 1996-01-29 | 1997-08-20 | Edward Mendell Co. Inc. | Sustained release excipient |
| AU3205497A (en) * | 1996-05-23 | 1997-12-09 | G.D. Searle & Co. | Pharmaceutical compositions containing non-racemic verapamil and process for optimizing the pharmaceutical activity of r- and s-verapamil |
| IL123505A (en) | 1996-07-08 | 2004-12-15 | Penwest Pharmaceuticals Compan | Sustained release matrix for high-dose insoluble drugs |
| IN186245B (es) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
| DE69940557D1 (de) * | 1998-12-11 | 2009-04-23 | Nostrum Pharmaceuticals Inc | Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung |
| US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
| US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
| GB9910212D0 (en) * | 1999-05-05 | 1999-06-30 | Reckitt & Colmann Prod Ltd | Improvements in or relating to organic compositions |
| RU2145214C1 (ru) * | 1999-07-08 | 2000-02-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Фармацевтическая композиция, обладающая сердечно-сосудистым действием |
| ES2304980T3 (es) * | 1999-09-30 | 2008-11-01 | Penwest Pharmaceuticals Co. | Sistemas de matriz de liberacion sostenida para farmacos altamente solubles. |
| US6500462B1 (en) | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
| IL155959A0 (en) | 2000-11-28 | 2003-12-23 | Fmc Corp | Edible pga (propylene glycol alginate) coating composition |
| US6932861B2 (en) | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| NZ527832A (en) | 2001-03-13 | 2006-03-31 | Penwest Pharmaceuticals Co | Chronotherapeutic dosage forms |
| EP1245227A1 (en) * | 2001-03-31 | 2002-10-02 | Jagotec Ag | A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same |
| CN1610551A (zh) | 2001-07-06 | 2005-04-27 | 恩德制药公司 | 用作止痛剂的6-羟基羟吗啡酮的肠胃外给药 |
| CA2481091A1 (en) * | 2002-04-05 | 2003-10-23 | Penwest Pharmaceuticals Co. | Sustained release metoprolol formulations |
| US20040005359A1 (en) * | 2002-06-27 | 2004-01-08 | Cheng Xiu Xiu | Controlled release oral dosage form |
| AU2003261298A1 (en) * | 2002-08-02 | 2004-02-23 | Penwest Pharmaceuticals Company | Sustained release formulations of metformin |
| EA200600598A1 (ru) | 2003-09-19 | 2006-08-25 | Пенвест Фармасьютикалз Ко. | Лекарственные формы замедленного высвобождения |
| WO2008045060A1 (en) * | 2006-10-10 | 2008-04-17 | Penwest Pharmaceuticals Co. | Robust sustained release formulations |
| JP5463537B2 (ja) * | 2008-02-22 | 2014-04-09 | HOYA Technosurgical株式会社 | 分離方法 |
| US20100159001A1 (en) * | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
| US20100160363A1 (en) * | 2008-12-19 | 2010-06-24 | Aaipharma Services Corp. | Extended-release pharmaceutical formulations |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2993836A (en) * | 1958-02-20 | 1961-07-25 | Dow Chemical Co | Sustained release tablets |
| US3079303A (en) * | 1958-12-11 | 1963-02-26 | Smith Kline French Lab | Basic tablet granulation and process of using same |
| NL265428A (es) * | 1960-06-06 | |||
| US3133863A (en) * | 1961-03-10 | 1964-05-19 | Strong Cobb Arner Inc | Sustained release therapeutic tablet compositions comprising organic solvent-gelled gums |
| US3147187A (en) * | 1962-09-10 | 1964-09-01 | Don Hall Lab | Sustained release pharmaceutical |
| US3388041A (en) * | 1964-01-27 | 1968-06-11 | Richardson Merrell Inc | High dosage sustained release tablet |
| GB1097207A (en) * | 1964-08-24 | 1967-12-29 | Collett & Co As | Process for the preparation of sustained action tablets |
| US3456049A (en) * | 1965-05-25 | 1969-07-15 | Ciba Geigy Corp | Gradual-release tablet |
| US3726690A (en) * | 1965-10-22 | 1973-04-10 | Kelco Co | Acidified food products containing xanthomonas colloid |
| US3864469A (en) * | 1967-12-16 | 1975-02-04 | Hoechst Ag | Xanthines in pharmaceutical preparations and for stabilization of vitamins |
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| US3629393A (en) * | 1969-09-11 | 1971-12-21 | Nikken Chemicals Co Ltd | Release-sustaining-tablet |
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| US3836618A (en) * | 1971-12-23 | 1974-09-17 | American Home Prod | Process for the uniform distribution of a drug on a granulated base |
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| US4439453A (en) * | 1980-12-22 | 1984-03-27 | Monsanto Company | Directly compressible acetaminophen granulation |
| DE3127237A1 (de) * | 1981-07-10 | 1983-01-20 | Hoechst Ag, 6000 Frankfurt | Magenvertraegliche arzneiformen von xanthinderivaten und verfahren zu ihrer herstellung |
| US4424235A (en) * | 1981-09-14 | 1984-01-03 | Hoffmann-La Roche Inc. | Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor |
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| US4556678A (en) * | 1982-06-24 | 1985-12-03 | Key Pharmaceuticals, Inc. | Sustained release propranolol tablet |
| US4698264A (en) * | 1982-08-02 | 1987-10-06 | Durkee Industrial Foods, Corp. | Particulate composition and process for making same |
| US4698101A (en) * | 1982-08-30 | 1987-10-06 | Suomen Sokeri Oy (Finnish Sugar Company Ltd.) | Binder-diluent composition and method |
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| JPS6124516A (ja) * | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | 持続性錠剤 |
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| GB8518927D0 (en) * | 1985-07-26 | 1985-09-04 | Vincent Processes Ltd | Tablets |
| GB8522453D0 (en) * | 1985-09-11 | 1985-10-16 | Lilly Industries Ltd | Chewable capsules |
| US4704285A (en) * | 1985-11-18 | 1987-11-03 | The Dow Chemical Company | Sustained release compositions comprising hydroxypropyl cellulose ethers |
| GB8601204D0 (en) * | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
| IT1191674B (it) * | 1986-03-07 | 1988-03-23 | Eurand Spa | Formulazioni per la preparazione di farmaci a rilascio prolungato adatte alla somministrazione per via orale |
| US4855143A (en) * | 1986-04-04 | 1989-08-08 | Hans Lowey | Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics |
| GB8608818D0 (en) * | 1986-04-11 | 1986-05-14 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions |
| GB8613689D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| JPH0826346B2 (ja) * | 1986-07-10 | 1996-03-13 | 株式会社林原生物化学研究所 | 固状油溶性物質の製法 |
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-
1991
- 1991-07-25 US US07/736,031 patent/US5169639A/en not_active Expired - Lifetime
-
1992
- 1992-07-02 AU AU24033/92A patent/AU649163B2/en not_active Ceased
- 1992-07-02 KR KR1019930700917A patent/KR0184308B1/ko not_active Expired - Fee Related
- 1992-07-02 DK DK92916803.7T patent/DK0550737T3/da active
- 1992-07-02 CA CA002092287A patent/CA2092287C/en not_active Expired - Fee Related
- 1992-07-02 ES ES92916803T patent/ES2099273T3/es not_active Expired - Lifetime
- 1992-07-02 HU HU9300768A patent/HU218658B/hu not_active IP Right Cessation
- 1992-07-02 DE DE69217031T patent/DE69217031T2/de not_active Expired - Fee Related
- 1992-07-02 WO PCT/US1992/005712 patent/WO1993001803A1/en not_active Ceased
- 1992-07-02 AT AT92916803T patent/ATE147974T1/de not_active IP Right Cessation
- 1992-07-02 JP JP5502844A patent/JPH0733339B2/ja not_active Expired - Fee Related
- 1992-07-02 EP EP92916803A patent/EP0550737B1/en not_active Expired - Lifetime
- 1992-07-23 IL IL10261492A patent/IL102614A/xx not_active IP Right Cessation
- 1992-07-24 MX MX9204352A patent/MX9204352A/es not_active IP Right Cessation
- 1992-07-24 IE IE241192A patent/IE922411A1/en not_active IP Right Cessation
-
1993
- 1993-03-25 FI FI931342A patent/FI107231B/fi active
-
1997
- 1997-04-09 GR GR970400758T patent/GR3023086T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69217031D1 (de) | 1997-03-06 |
| FI931342A0 (fi) | 1993-03-25 |
| CA2092287C (en) | 1997-03-25 |
| IL102614A (en) | 1997-02-18 |
| JPH06500576A (ja) | 1994-01-20 |
| CA2092287A1 (en) | 1993-01-26 |
| KR0184308B1 (ko) | 1999-05-01 |
| ATE147974T1 (de) | 1997-02-15 |
| JPH0733339B2 (ja) | 1995-04-12 |
| IL102614A0 (en) | 1993-01-14 |
| MX9204352A (es) | 1993-04-01 |
| FI931342L (fi) | 1993-03-25 |
| EP0550737A1 (en) | 1993-07-14 |
| AU2403392A (en) | 1993-02-23 |
| HU218658B (hu) | 2000-10-28 |
| WO1993001803A1 (en) | 1993-02-04 |
| HU9300768D0 (en) | 1993-06-28 |
| DK0550737T3 (es) | 1997-02-17 |
| DE69217031T2 (de) | 1997-05-07 |
| KR930701983A (ko) | 1993-09-08 |
| EP0550737A4 (en) | 1993-12-15 |
| AU649163B2 (en) | 1994-05-12 |
| EP0550737B1 (en) | 1997-01-22 |
| IE922411A1 (en) | 1993-01-27 |
| GR3023086T3 (en) | 1997-07-30 |
| FI107231B (fi) | 2001-06-29 |
| US5169639A (en) | 1992-12-08 |
| HUT64221A (en) | 1993-12-28 |
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