ES2099280T3 - Complejos macrociclicos de tierras raras y su utilizacion para reducir las interferencias en un dosificado por fluorescencia. - Google Patents

Complejos macrociclicos de tierras raras y su utilizacion para reducir las interferencias en un dosificado por fluorescencia.

Info

Publication number
ES2099280T3
ES2099280T3 ES92919653T ES92919653T ES2099280T3 ES 2099280 T3 ES2099280 T3 ES 2099280T3 ES 92919653 T ES92919653 T ES 92919653T ES 92919653 T ES92919653 T ES 92919653T ES 2099280 T3 ES2099280 T3 ES 2099280T3
Authority
ES
Spain
Prior art keywords
radicals
fluorescence
mulecular
oxi
constituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92919653T
Other languages
English (en)
Inventor
Jean-Marie Lehn
Christine Odile Roth
Gerard Mathis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
CIS Bio International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CIS Bio International SA filed Critical CIS Bio International SA
Application granted granted Critical
Publication of ES2099280T3 publication Critical patent/ES2099280T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION CONCIERNE A COMPLEJOS MACROCICLICOS DE TIERRAS RARAS, CARACTERIZADOS EN QUE ESTAN CONSTITUIDOS POR AL MENOS UNA SAL DE TIERRA RARA COMPLEJADA POR UN COMPUESTO MACROTOCICLICO DE FORMULA (I), EN LA CUAL LOS RADICALES BIVALENTES A, B, C Y D, IDENTICOS O DIFERENTES, REPRESENTAN CADENAS HIDROCARBONADAS QUE CONTIENEN EVENTUALMENTE UNO O VARIOS HETEROATOMOS, UNO AL MENOS DE DICHOS RADICALES INCLUYE AL MENOS UN MOTIVO MOLECULAR O ESTA ESENCIALMENTE CONSTITUIDO POR UN MOTIVO MOLECULAR QUE POSEE UNA ENERGIA DE TRIPLETE SUPERIOR A LA DEL NIVEL EMISIVO DEL ION DE TIERRA RARA COMPLEJADO, UNO AL MENOS DE DICHOS RADICALES ESTA CONSTITUIDO POR UN SISTEMA HETEROCICLICO NITROGENADO SUSTITUIDO O NO SUSTITUIDO DE LOS QUE UNO AL MENOS DE LOS ATOMOS DE NITROGENO LLEVA UN GRUPO OXI, Y UNO DE LOS RADICALES C O D PUEDE NO EXISTIR; X1 Y X2, IDENTICOS O DIFERENTES REPRESENTAN HIDROGENO O UNA CADENA HIDROCARBONADA (CH2)N EVENTUALMENTE INTERRUMPIDA POR 1 O VARIOS HETEROATOMOS, EN LA CUAL N ES UN ENTERO DE1 A 10, CON SALVEDAD DE QUE UNO AL MENOS DE LOS ATOMOS DE NITROGENO LLEVA UN GRUPO OXI, LOS RADICALES C Y/O D ESTAN ESCOGIDOS ENTRE LAS BIQUINOLEINAS, LAS BI-ISOQUINOLEINAS, LAS BIPIRIDINAS, LAS TER-PIRIDINAS, LAS CONMARINAS, LAS BIPIRAZINAS, LAS BIPIRIMIDINAS Y LAS PIRIDINAS, ASI COMO SU UTILIZACION PARA REDUCIR LAS INTERFERENCIAS EN UNA DOSIFICACION POR FLUORESCENCIA.
ES92919653T 1991-08-30 1992-08-28 Complejos macrociclicos de tierras raras y su utilizacion para reducir las interferencias en un dosificado por fluorescencia. Expired - Lifetime ES2099280T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9110809A FR2680787B1 (fr) 1991-08-30 1991-08-30 Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence.

Publications (1)

Publication Number Publication Date
ES2099280T3 true ES2099280T3 (es) 1997-05-16

Family

ID=9416529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92919653T Expired - Lifetime ES2099280T3 (es) 1991-08-30 1992-08-28 Complejos macrociclicos de tierras raras y su utilizacion para reducir las interferencias en un dosificado por fluorescencia.

Country Status (9)

Country Link
US (1) US5457184A (es)
EP (1) EP0601113B1 (es)
JP (1) JP3345417B2 (es)
AT (1) ATE147391T1 (es)
AU (1) AU2568092A (es)
DE (1) DE69216621T2 (es)
ES (1) ES2099280T3 (es)
FR (1) FR2680787B1 (es)
WO (1) WO1993005049A1 (es)

Families Citing this family (42)

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US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
FR2735238B1 (fr) * 1995-06-09 1997-09-05 Cis Bio Int Utilisation d'un complexe phycobiliproteine-peptide de liaison en tant que traceur fluorescent
EP0846003A1 (en) 1995-08-17 1998-06-10 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
US5859215A (en) * 1995-10-25 1999-01-12 Wallac Oy Biospecific binding reactants labelled with luminescent lanthanide chelates and their use
FR2768817B1 (fr) * 1997-09-19 1999-12-10 Cis Bio Int Methode homogene pour la detection et/ou la determination de l'activite phosphorylante d'un materiel biologique
FR2809817B1 (fr) 2000-06-02 2003-08-15 Cis Bio Int Procede de detection de presence d'un liquide dans un melange
US7018851B2 (en) 2003-02-13 2006-03-28 Innotrac Diagnostics Oy Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
WO2006014645A1 (en) * 2004-07-23 2006-02-09 Amgen Inc. Generic probes for the detection of phosphorylated sequences
FR2878850B1 (fr) * 2004-12-02 2008-10-31 Cis Bio Internat Sa Derives de l'inositol-1-phosphate
FR2890174B1 (fr) * 2005-08-30 2009-04-24 Cis Bio Internat Sa Procede pour la mise en evidence d'un processus biologique par mesure d'un fret
FR2890446B1 (fr) 2005-09-05 2008-04-18 Cis Bio Internat Sa Methode de detection d'interaction intracellulaire entre bio-molecules
US7482444B2 (en) 2006-03-13 2009-01-27 Wallac Oy Terminating substrates for DNA polymerases
US8216856B2 (en) 2006-08-18 2012-07-10 Abacus Diagnostica Oy Luminescent lanthanide labelling reagents and their use
US20090306368A1 (en) * 2006-11-27 2009-12-10 Sumitomo Chemical Company, Limited Polynuclear complex
WO2010006605A2 (en) 2008-07-16 2010-01-21 Radiometer Medical Aps Thrombin substrate and assay for determining the level of bioactive thrombin in a sample
FR2934684B1 (fr) 2008-07-31 2012-11-16 Cis Bio Int Methode de detection de l'internalisation de proteines membranaires.
FR2936245B1 (fr) 2008-09-23 2012-07-06 Cis Bio Int Nouveaux substrats d'o6-alkylguanine-adn alkyltransferase et ses mutants.
FR2940286B1 (fr) 2008-12-19 2011-04-08 Cis Bio Int Nouveaux cryptates de terres rares comportant un motif tetraazatriphenylene
US8697380B2 (en) 2009-04-30 2014-04-15 Cis Bio International Method for detecting compounds modulating dimers of VFT domain membrane proteins
FR2949156B1 (fr) 2009-08-13 2016-04-15 Cis-Bio Int Methode de determination de la liaison d'un compose donne a un recepteur membranaire
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
FR2977674B1 (fr) 2011-07-06 2015-08-14 Cisbio Bioassays Methode amelioree de detection et/ou de quantification d'un analyte present a la surface d'une cellule
FR2978149B1 (fr) 2011-07-18 2014-01-10 Cisbio Bioassays Nouveaux agents complexants et complexes de lanthanide correspondant, et leur utilisation comme marqueurs luminescents
FR2980271B1 (fr) 2011-09-16 2013-10-11 Cisbio Bioassays Procede de determination de la glycosylation d'un anticorps
US20150185150A1 (en) 2012-02-22 2015-07-02 Cisbio Bioassays Method for normalizing the luminescence emitted by a measuring medium
FR2988174B1 (fr) 2012-03-19 2014-04-25 Cisbio Bioassays Procede de determination de la capacite d'un anticorps a maintenir des cellules a proximite l'une de l'autre
FR3000960B1 (fr) 2013-01-16 2015-03-06 Cisbio Bioassays Nouveaux agents complexants hydrosolubles et complexes de lanthanide correspondants
FR3004189B1 (fr) 2013-04-04 2015-09-04 Ecole Norm Superieure Lyon Complexes de lanthanide comprenant au moins deux groupes betaines, utiles comme marqueurs luminescents
FR3032797B1 (fr) 2015-02-13 2017-03-03 Cisbio Bioassays Procede de quantification d'une proteine d'interet presente dans un echantillon biologique
FR3045053B1 (fr) 2015-12-09 2018-01-05 Cisbio Bioassays Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants
FR3067349B1 (fr) 2017-06-12 2020-12-04 Cisbio Bioassays Nouveaux agents mono et di-antennes complexants hydrosolubles et complexes de lanthanide correspondants
FR3067712B1 (fr) 2017-06-14 2019-08-02 Cisbio Bioassays Nouveaux agents complexants de type trimethoxyphenyl pyridine hydrosolubles et complexes de lanthanide correspondants
FR3069644B1 (fr) 2017-07-28 2024-07-12 Cisbio Bioassays Methode pour mesurer la modulation de l'activation d'un recepteur couple a une proteine g
FR3084365B1 (fr) 2018-07-27 2020-10-23 Cisbio Bioassays Anticorps a domaine unique qui se lient a la proteine g alpha
FR3092172B1 (fr) 2019-01-30 2021-02-12 Cisbio Bioassays Méthode pour mesurer la modulation de l’activation d’un récepteur couplé à une protéine G avec des analogues du GTP
CN113801148B (zh) * 2020-06-15 2022-11-22 北京大学 亚铕大环配合物及其作为电致发光材料的应用
CN112521937B (zh) * 2020-12-10 2022-07-19 四川师范大学 一种可用于尿酸检测的稀土荧光复合材料的制备及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570703B1 (fr) * 1984-09-26 1988-07-08 Commissariat Energie Atomique Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents
US5220012A (en) * 1984-09-26 1993-06-15 Compagnie Oris Industrie Sa Macropolycyclic rare earth complexes and application as fluorescent tracers
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
SE8800613D0 (sv) * 1988-02-23 1988-02-23 Wallac Oy A novel spectrofluorometric method and compounds that are of value for the method
US5403928A (en) * 1990-05-15 1995-04-04 Diatron Corporation Fluorescent marker components and fluorescent probes

Also Published As

Publication number Publication date
DE69216621D1 (de) 1997-02-20
JP3345417B2 (ja) 2002-11-18
EP0601113B1 (fr) 1997-01-08
JPH06510296A (ja) 1994-11-17
FR2680787B1 (fr) 1994-11-04
EP0601113A1 (fr) 1994-06-15
US5457184A (en) 1995-10-10
ATE147391T1 (de) 1997-01-15
FR2680787A1 (fr) 1993-03-05
DE69216621T2 (de) 1997-07-24
AU2568092A (en) 1993-04-05
WO1993005049A1 (fr) 1993-03-18

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