ES2099876T3 - Procedimiento para la determinacion de anticuerpos de lupus anticoagulante que provocan trombosis. - Google Patents

Procedimiento para la determinacion de anticuerpos de lupus anticoagulante que provocan trombosis.

Info

Publication number
ES2099876T3
ES2099876T3 ES93114270T ES93114270T ES2099876T3 ES 2099876 T3 ES2099876 T3 ES 2099876T3 ES 93114270 T ES93114270 T ES 93114270T ES 93114270 T ES93114270 T ES 93114270T ES 2099876 T3 ES2099876 T3 ES 2099876T3
Authority
ES
Spain
Prior art keywords
antibodies
protein
determination
procedure
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93114270T
Other languages
English (en)
Inventor
Gert Prof Dr Muller-Berghaus
Bernd Dr Med Potzsch
Christoph Seelig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6467450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2099876(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Application granted granted Critical
Publication of ES2099876T3 publication Critical patent/ES2099876T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96463—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PARA DETERMINAR ANTICUERPOS (LA) ANTICOAGULANTES LUPUS, EN PRUEBAS DE SANGRE, PLASMA O TEJIDO. PARA LA INHIBICION DE LA ACCION NEUTRALIZADORA A TRAVES DEL ANTICUERPO QUE EJERCE LA PROTEINA C ACTIVADA SOBRE EL SISTEMA DE COAGULACION DE LA SANGRE, SE ADICIONA UNA CANTIDAD DEFINIDA DE PROTEINA C ACTIVA A LA MUESTRA, DESPUES DE LA INCUBACION SE DETERMINA LA CANTIDAD DE UNOS SUBSTRATOS FISIOLOGICOS DE PROTEINA C O LA ACTIVIDAD S DE LA PROTEINA QUE PERMANECE EN LA MUESTRA SEGUN METODOS CONOCIDOS Y SE CALCULA LA CANTIDAD EN ANTICUERPOS (LA) PRESENTE AL COMPARARLA CON UN STANDARD CONTENIENDO UNA PEQUEÑA CANTIDAD DE ANTICUERPO (LA). EL PROCEDIMIENTO CON ARREGLO A LA INVENCION ES APLICABLE EN LA DIAGNOSIS DE UNA PREDISPOSICION PARA CASOS TROMBOTICOS O PELIGRO DE TROMBOSIS EN CONDICIONES DE DOLENCIA ASI COMO PARA EL CONTROL DE LA TERAPIA.
ES93114270T 1992-09-08 1993-09-06 Procedimiento para la determinacion de anticuerpos de lupus anticoagulante que provocan trombosis. Expired - Lifetime ES2099876T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4229933A DE4229933A1 (de) 1992-09-08 1992-09-08 Verfahren zur Bestimmung von Thrombose verursachenden Lupus-anticoagulant-Antikörpern

Publications (1)

Publication Number Publication Date
ES2099876T3 true ES2099876T3 (es) 1997-06-01

Family

ID=6467450

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93114270T Expired - Lifetime ES2099876T3 (es) 1992-09-08 1993-09-06 Procedimiento para la determinacion de anticuerpos de lupus anticoagulante que provocan trombosis.

Country Status (9)

Country Link
US (1) US5610024A (es)
EP (1) EP0587090B1 (es)
JP (1) JP3461871B2 (es)
AT (1) ATE148233T1 (es)
AU (1) AU674149B2 (es)
CA (1) CA2105606C (es)
DE (2) DE4229933A1 (es)
DK (1) DK0587090T3 (es)
ES (1) ES2099876T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2139957T3 (es) 1994-07-23 2000-02-16 Roche Diagnostics Gmbh Metodo para la determinacion del estado pretrombotico.
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
RU2181203C2 (ru) * 1999-03-23 2002-04-10 Алтайский государственный медицинский университет Способ определения волчаночного антикоагулянта
US6777193B1 (en) * 2000-08-04 2004-08-17 Escuela Nacional De Ciencias Biologicas, Del Instituto Politecnico Nacional Methods for diagnostic and/or treatment of antiphospholipids antibodies-related diseases, and devices
RU2239197C1 (ru) * 2003-01-23 2004-10-27 Межрегиональная благотворительная общественная организация инвалидов "Общество больных гемофилией" Способ определения волчаночного антикоагулянта
EP2634583A1 (de) * 2012-02-28 2013-09-04 Siemens Healthcare Diagnostics Products GmbH Screening-Methode zum Auffinden von Proben mit Antiphospholipid-Antikörpern
CN114740211A (zh) * 2022-03-11 2022-07-12 武汉亚洲心脏病医院 新型抗凝药中和试管

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US505135A (en) 1893-09-19 Rail-heating device
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
US4908314A (en) * 1987-07-02 1990-03-13 American National Red Cross Protein C activator
US5051357A (en) * 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor
SE464135B (sv) * 1989-07-14 1991-03-11 Kabivitrum Ab Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
ATE140798T1 (de) * 1990-12-07 1996-08-15 Liposome Co Inc Lipid-abhängige diagnostische analysenverfahren
WO1993010261A1 (en) * 1991-11-13 1993-05-27 Dahlbaeck Bjoern Method for the diagnosis of blood coagulation disorders
JPH05180835A (ja) * 1991-12-27 1993-07-23 S R L:Kk ループスアンチコアグラントの測定方法
US5472852A (en) * 1993-09-15 1995-12-05 Oklahoma Medical Research Foundation Assay for detection of selective Protein C inhibition by patients

Also Published As

Publication number Publication date
JPH06174721A (ja) 1994-06-24
AU4484593A (en) 1994-03-17
EP0587090B1 (de) 1997-01-22
CA2105606C (en) 2004-07-06
DE4229933A1 (de) 1994-03-10
ATE148233T1 (de) 1997-02-15
DE59305225D1 (de) 1997-03-06
AU674149B2 (en) 1996-12-12
EP0587090A1 (de) 1994-03-16
US5610024A (en) 1997-03-11
CA2105606A1 (en) 1994-03-09
JP3461871B2 (ja) 2003-10-27
DK0587090T3 (da) 1997-07-07

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