ES2101891T3 - Obtencion de esteres del acido isoxazol-3-carboxiamida-4-carboxilico mediante amidacion selectiva. - Google Patents
Obtencion de esteres del acido isoxazol-3-carboxiamida-4-carboxilico mediante amidacion selectiva.Info
- Publication number
- ES2101891T3 ES2101891T3 ES93103911T ES93103911T ES2101891T3 ES 2101891 T3 ES2101891 T3 ES 2101891T3 ES 93103911 T ES93103911 T ES 93103911T ES 93103911 T ES93103911 T ES 93103911T ES 2101891 T3 ES2101891 T3 ES 2101891T3
- Authority
- ES
- Spain
- Prior art keywords
- carboxilico
- acid
- carboxiamida
- obtaining esters
- selective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 230000009435 amidation Effects 0.000 title 1
- 238000007112 amidation reaction Methods 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- AXLOCHLTNQDFFS-BESJYZOMSA-N azastene Chemical compound C([C@H]1[C@@H]2CC[C@@]([C@]2(CC[C@@H]1[C@@]1(C)C2)C)(O)C)C=C1C(C)(C)C1=C2C=NO1 AXLOCHLTNQDFFS-BESJYZOMSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
OBTENCION DE ESTERES DEL ACIDO ISOXAZOL IDO CARBOXILICO SUSTITUYENTES TIENEN LOS SIGNIFICADOS SIGUIENTES: R1 HIDROGENO, ALQUILO, CICLOALQUILO, FENILO O UN RESTO HETEROCICLICO DE 5 A 6 ESLABONES, POR EL QUE LOS RESTOS ORGANICOS, BAJO LAS CONDICIONES DE REACCION, PUEDEN TENER SUSTITUYENTES INERTES; R2 ALQUILO, CICLOALQUILO, BENCILO O UN RESTO C3 IDROGENO, ALQUILO, CICLOALQUILO, Y R4 UN RESTO FENILO ALIFATICO, CICLOALIFATICO O DADO ES CASO SUSTITUIDO, O R4 JUNTO CON R3, UNA CADENA ALQUILENO, CON 4 A 7 ESLABONES, QUE PUEDE SER INTERRUMPIDA POR OXIGENO, AZUFRE O N METILO, POR MEDIO DE AMIDIZACION SELECTIVA DE UN ESTER DEL ACIDO ISOXAZOL LICO, DE FORMULA II EN LA QUE R2'' TIENE EL SIGNIFICADO DE R2 Y ES IGUAL O DIFERENTE DE R2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4209849A DE4209849A1 (de) | 1992-03-26 | 1992-03-26 | Herstellung von Isoxazol-3-carbonsäureamid-4-carbonsäureestern durch selektive Amidierung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2101891T3 true ES2101891T3 (es) | 1997-07-16 |
Family
ID=6455083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93103911T Expired - Lifetime ES2101891T3 (es) | 1992-03-26 | 1993-03-11 | Obtencion de esteres del acido isoxazol-3-carboxiamida-4-carboxilico mediante amidacion selectiva. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5276160A (es) |
| EP (1) | EP0562377B1 (es) |
| JP (1) | JPH0616650A (es) |
| KR (1) | KR930019653A (es) |
| DE (2) | DE4209849A1 (es) |
| ES (1) | ES2101891T3 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994024095A1 (en) * | 1993-04-16 | 1994-10-27 | Abbott Laboratories | Immunosuppressive agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59009528D1 (de) * | 1989-09-22 | 1995-09-21 | Basf Ag | Carbonsäureamide. |
| DE3931627A1 (de) * | 1989-09-22 | 1991-04-04 | Basf Ag | Carbonsaeureamide |
| US5001124A (en) * | 1990-02-02 | 1991-03-19 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
-
1992
- 1992-03-26 DE DE4209849A patent/DE4209849A1/de not_active Withdrawn
-
1993
- 1993-03-11 EP EP93103911A patent/EP0562377B1/de not_active Expired - Lifetime
- 1993-03-11 DE DE59306426T patent/DE59306426D1/de not_active Expired - Lifetime
- 1993-03-11 ES ES93103911T patent/ES2101891T3/es not_active Expired - Lifetime
- 1993-03-22 JP JP5061719A patent/JPH0616650A/ja not_active Withdrawn
- 1993-03-23 US US08/035,660 patent/US5276160A/en not_active Expired - Fee Related
- 1993-03-25 KR KR1019930004652A patent/KR930019653A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0562377A1 (de) | 1993-09-29 |
| DE4209849A1 (de) | 1993-09-30 |
| EP0562377B1 (de) | 1997-05-14 |
| JPH0616650A (ja) | 1994-01-25 |
| KR930019653A (ko) | 1993-10-18 |
| DE59306426D1 (de) | 1997-06-19 |
| US5276160A (en) | 1994-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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