ES2106010T3 - Sistemas de ensayo que comprenden equivalentes de tejido. - Google Patents
Sistemas de ensayo que comprenden equivalentes de tejido.Info
- Publication number
- ES2106010T3 ES2106010T3 ES88302953T ES88302953T ES2106010T3 ES 2106010 T3 ES2106010 T3 ES 2106010T3 ES 88302953 T ES88302953 T ES 88302953T ES 88302953 T ES88302953 T ES 88302953T ES 2106010 T3 ES2106010 T3 ES 2106010T3
- Authority
- ES
- Spain
- Prior art keywords
- tissue
- systems including
- test systems
- including tissue
- limited
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000001519 tissue Anatomy 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000000981 epithelium Anatomy 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 210000004907 gland Anatomy 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000002669 organ and tissue protective effect Effects 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA METODOS, APARATOS Y KITS PARA DETERMINAR LA INTERACCION DE TEJIDOS Y POR LO MENOS UN AGENTE MEDIANTE EL EMPLEO DE AL MENOS UN EQUIVALENTE TISULAR. EL EQUIVALENTE TISULAR INCLUYE, PERO NO SE LIMITA A, EQUIVALENTES DE TEJIDO EPITELIAL, TEJIDO CONJUNTIVO, CARTILAGO, HUESOS, SANGRE, ORGANOS, GLANDULAS Y VASOS SANGUINEOS, QUE COMPONEN DE CELULAS VIVAS Y MOLEUCLAS DE MATRIZ EXTRACELULARE, PRINCIPALMENTE COLAGENO. LOS AGENTES INCLUYEN, PERO NO SE LIMITAN A, DIVERSAS SUSTANCIAS TALES COMO PRODUCTOS QUIMICOS, COSMETICOS, PRODUCTOS FARMACEUTICOS, ESTIMULOS (POR EJEMPLO LUZ O DAÑO FISICO); Y AGENTES PROTECTORES DE TEJIDOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/032,848 US4835102A (en) | 1987-03-31 | 1987-03-31 | Tissue equivalent test systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2106010T3 true ES2106010T3 (es) | 1997-11-01 |
Family
ID=21867144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88302953T Expired - Lifetime ES2106010T3 (es) | 1987-03-31 | 1988-03-31 | Sistemas de ensayo que comprenden equivalentes de tejido. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4835102A (es) |
| EP (1) | EP0295762B1 (es) |
| JP (1) | JP2767803B2 (es) |
| AT (1) | ATE156915T1 (es) |
| CA (1) | CA1305913C (es) |
| DE (1) | DE3855991T2 (es) |
| ES (1) | ES2106010T3 (es) |
| GR (1) | GR3025046T3 (es) |
| IL (1) | IL85599A (es) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5160490A (en) * | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
| US5266480A (en) * | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| US5510254A (en) * | 1986-04-18 | 1996-04-23 | Advanced Tissue Sciences, Inc. | Three dimensional cell and tissue culture system |
| US5032508A (en) * | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| US5863531A (en) * | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5053340A (en) * | 1989-02-24 | 1991-10-01 | National Testing Corporation | In vitro test for dermal toxic properties |
| US5175092A (en) * | 1989-05-04 | 1992-12-29 | Millipore Corporation | Vitro toxicology kit and method therefor |
| DE3923279A1 (de) * | 1989-07-14 | 1990-01-18 | Will W Prof Dr Minuth | Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren |
| US5106949A (en) * | 1989-09-15 | 1992-04-21 | Organogenesis, Inc. | Collagen compositions and methods for preparation thereof |
| IL95429A (en) * | 1989-09-15 | 1997-09-30 | Organogenesis | Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production |
| RU2135191C1 (ru) * | 1990-04-24 | 1999-08-27 | Ортек Интернэшнл, Инк. | Композиционный эквивалент живой кожи, способ его получения, тест-набор |
| US5192312A (en) * | 1991-03-05 | 1993-03-09 | Colorado State University Research Foundation | Treated tissue for implantation and methods of treatment and use |
| US5612188A (en) * | 1991-11-25 | 1997-03-18 | Cornell Research Foundation, Inc. | Automated, multicompartmental cell culture system |
| AU3603693A (en) * | 1992-02-04 | 1993-09-01 | Ohmicron Corporation | Immunological analogs for captan |
| WO1993017336A1 (en) * | 1992-02-19 | 1993-09-02 | The Procter & Gamble Company | In vitro model for eye and skin irritation testing |
| US5478739A (en) * | 1992-10-23 | 1995-12-26 | Advanced Tissue Sciences, Inc. | Three-dimensional stromal cell and tissue culture system |
| US5888720A (en) * | 1992-10-27 | 1999-03-30 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs |
| US5585265A (en) * | 1992-11-30 | 1996-12-17 | Gillette Company | Human corneal epithelial cell lines with extended lifespan |
| US5656492A (en) * | 1993-02-12 | 1997-08-12 | Brigham And Women's Hospital, Inc. | Cell induction device |
| CA2119064A1 (en) * | 1993-03-17 | 1994-09-18 | Richard A. Berg | Dermal-epidermal in vitro test system |
| WO1995011989A1 (en) * | 1993-10-29 | 1995-05-04 | Invitro International | In vitro fluid toxicity bioassay |
| WO1995014221A1 (en) * | 1993-11-18 | 1995-05-26 | Ramsay Hospital Holdings Pty. Ltd. | Processing cassette for tissue samples |
| US5672498A (en) * | 1993-12-28 | 1997-09-30 | The Gillete Company | Human corneal epithelial cell lines with extended lifespan |
| WO1995024873A1 (en) * | 1994-03-14 | 1995-09-21 | Cryolife, Inc. | Treated tissue for implantation and preparation methods |
| US5693085A (en) | 1994-04-29 | 1997-12-02 | Scimed Life Systems, Inc. | Stent with collagen |
| JP2858087B2 (ja) * | 1994-09-19 | 1999-02-17 | グンゼ株式会社 | 組織培養用基材及び組織培養法 |
| US5948654A (en) | 1996-08-28 | 1999-09-07 | Univ Minnesota | Magnetically oriented tissue-equivalent and biopolymer tubes comprising collagen |
| US6057137A (en) | 1994-10-06 | 2000-05-02 | Regents Of The University Of Minnesota | Tissue-equivalent rods containing aligned collagen fibrils and schwann cells |
| US20030152909A1 (en) * | 1994-11-16 | 2003-08-14 | Mitrani Eduardo N. | In vitro micro-organs, and uses related thereto |
| US6121042A (en) * | 1995-04-27 | 2000-09-19 | Advanced Tissue Sciences, Inc. | Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs |
| US20040002772A1 (en) * | 1995-04-28 | 2004-01-01 | Organogenesis, Inc. | Tissue equivalents with perforations for improved integration to host tissues and methods for producing perforated tissue equivalents |
| US5814328A (en) * | 1997-01-13 | 1998-09-29 | Gunasekaran; Subramanian | Preparation of collagen using papain and a reducing agent |
| US5846188A (en) * | 1997-01-17 | 1998-12-08 | Palti; Yoram | Sensor utilizing living muscle cells |
| KR20000076136A (ko) | 1997-03-11 | 2000-12-26 | 스즈키 츠네시 | 피부 상태 개선제의 평가 방법 및 피부 외용제의 제조 방법 |
| US7687057B2 (en) * | 1998-01-09 | 2010-03-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
| US6066495A (en) * | 1998-03-05 | 2000-05-23 | Tissue Engineering, Inc. | Methods and apparatus for the conditioning of ligament replacement tissue |
| AU3077299A (en) | 1998-03-11 | 1999-09-27 | University Of Southern California | Method of promoting production of living tissue equivalents |
| US6432710B1 (en) * | 1998-05-22 | 2002-08-13 | Isolagen Technologies, Inc. | Compositions for regenerating tissue that has deteriorated, and methods for using such compositions |
| US6293970B1 (en) | 1998-06-30 | 2001-09-25 | Lifenet | Plasticized bone and soft tissue grafts and methods of making and using same |
| US7063726B2 (en) * | 1998-06-30 | 2006-06-20 | Lifenet | Plasticized bone grafts and methods of making and using same |
| US8563232B2 (en) * | 2000-09-12 | 2013-10-22 | Lifenet Health | Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced |
| US20100030340A1 (en) * | 1998-06-30 | 2010-02-04 | Wolfinbarger Jr Lloyd | Plasticized Grafts and Methods of Making and Using Same |
| AT407047B (de) * | 1998-08-03 | 2000-11-27 | Pfaller Walter Dr | Zellkulturvorrichtung |
| EP2295540A1 (en) | 1998-11-19 | 2011-03-16 | Organogenesis, Inc. | Bioengineered tissue constructs and methods for producing and using them |
| US6030789A (en) * | 1999-03-10 | 2000-02-29 | The Gillette Company | Human conjunctival epithelial cell lines with an extended life span |
| US6287340B1 (en) * | 1999-05-14 | 2001-09-11 | Trustees Of Tufts College | Bioengineered anterior cruciate ligament |
| US20060127366A1 (en) * | 1999-06-25 | 2006-06-15 | Mitrani Eduardo N | Method and device for inducing biological processes by micro-organs |
| WO2001092476A2 (de) * | 2000-05-31 | 2001-12-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | In vitro-gewebetestsystem |
| US6852526B2 (en) * | 2000-07-14 | 2005-02-08 | Transform Pharmaceuticals, Inc. | Transdermal assay with magnetic clamp |
| US20080182293A1 (en) * | 2000-07-14 | 2008-07-31 | Transform Pharmaceuticals, Inc. | Computerized control of high-throughput transdermal experimental processing and digital analysis of comparative samples |
| AU7788701A (en) * | 2000-07-14 | 2002-01-30 | Transform Pharmaceuticals Inc | System and method for optimizing tissue barrier transfer of compounds |
| US7172859B2 (en) * | 2000-07-14 | 2007-02-06 | Transform Pharmaceuticals, Inc. | System and method for optimizing tissue barrier transfer of compounds |
| AU2002341867A1 (en) * | 2001-09-27 | 2003-04-07 | The Wistar Institute | Methods and compositions for monitoring cell migration and identifying clinically relevant cytotoxic t lymphocyte activity |
| US20030166274A1 (en) * | 2001-11-15 | 2003-09-04 | Hewitt Charles W. | Three-dimensional matrix for producing living tissue equivalents |
| WO2003089566A1 (en) * | 2002-04-22 | 2003-10-30 | Tufts University | Multi-dimensional strain bioreactor |
| AUPS242702A0 (en) * | 2002-05-21 | 2002-06-13 | Colltech Australia Limited | Improved method for the extraction and purification of collagen |
| US7229820B2 (en) * | 2002-06-13 | 2007-06-12 | Wilson Wolf Manufacturing Corporation | Apparatus and method for culturing and preserving tissue constructs |
| US6908760B2 (en) * | 2002-10-28 | 2005-06-21 | Transform Pharmaceuticals, Inc. | Raised surface assay plate |
| US7449307B2 (en) * | 2002-10-28 | 2008-11-11 | Transform Pharmaceuticals, Inc. | Raised surface assay plate |
| US20040185430A1 (en) * | 2002-12-20 | 2004-09-23 | Marc Andre Lefebvre | Process for evaluating the cosmetic or dermatological activity of a product and use of plant material |
| US20090024224A1 (en) | 2007-07-16 | 2009-01-22 | Chen Silvia S | Implantation of cartilage |
| CN101918532B (zh) * | 2007-08-22 | 2016-03-30 | 普罗柏欧贞股份公司 | 用于体外测试免疫原性和免疫功能的培养系统和方法 |
| EP2238447B1 (en) * | 2008-01-10 | 2015-02-25 | L'Oreal, S.A. | Immune system modeling devices and methods |
| ES2672201T3 (es) | 2008-07-16 | 2018-06-13 | Children's Medical Center Corporation | Dispositivo de imitación de órganos con microcanales y métodos de uso |
| US8765254B2 (en) * | 2010-04-05 | 2014-07-01 | Emd Millipore Corporation | Polymeric membranes with human skin-like permeability properties and uses thereof |
| DK2681306T3 (en) | 2011-02-28 | 2019-04-23 | Harvard College | CELL CULTURE SYSTEM |
| US9725687B2 (en) | 2011-12-09 | 2017-08-08 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
| EP2725094A1 (en) * | 2012-10-29 | 2014-04-30 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Epithelial tissue model |
| EP3024582A4 (en) | 2013-07-22 | 2017-03-08 | President and Fellows of Harvard College | Microfluidic cartridge assembly |
| EP3574985A1 (en) | 2013-12-20 | 2019-12-04 | President And Fellows Of Harvard College | Organomimetic devices and methods of use and manufacturing thereof |
| JP2017504320A (ja) | 2013-12-20 | 2017-02-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 低剪断マイクロ流体デバイスならびにその使用および製造の方法 |
| WO2016010861A1 (en) | 2014-07-14 | 2016-01-21 | President And Fellows Of Harvard College | Systems and methods for improved performance of fluidic and microfluidic systems |
| US10202569B2 (en) | 2015-07-24 | 2019-02-12 | President And Fellows Of Harvard College | Radial microfluidic devices and methods of use |
| EP3512935B1 (en) | 2016-09-13 | 2022-02-23 | President and Fellows of Harvard College | Methods relating to intestinal organ-on-a-chip |
| CN112980690B (zh) * | 2019-12-17 | 2022-10-21 | 华东数字医学工程研究院 | Pdx模型孵育装置和抗肿瘤药物筛选方法 |
| JP2024529840A (ja) * | 2021-07-01 | 2024-08-14 | アップカラ インコーポレイテッド | ガラス化及びガラス化された生物活性剤の送達のための装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4539716A (en) * | 1981-03-19 | 1985-09-10 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
| US4546500A (en) * | 1981-05-08 | 1985-10-15 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
| EP0101715B1 (en) * | 1982-02-19 | 1986-12-10 | Endotronics Inc. | Process and apparatus for controlling patterns of chemicals stimuli administration to biological tissue |
| US4629686A (en) * | 1982-02-19 | 1986-12-16 | Endotronics, Inc. | Apparatus for delivering a controlled dosage of a chemical substance |
| US4485096A (en) * | 1982-02-26 | 1984-11-27 | Massachusetts Institute Of Technology | Tissue-equivalent and method for preparation thereof |
| US4485097A (en) * | 1982-05-26 | 1984-11-27 | Massachusetts Institute Of Technology | Bone-equivalent and method for preparation thereof |
| US4734372A (en) * | 1983-02-04 | 1988-03-29 | Brown University Research Foundation | Cell culturing methods and apparatus |
| US4559299A (en) * | 1983-02-04 | 1985-12-17 | Brown University Research Foundation Inc. | Cytotoxicity assays in cell culturing devices |
| JPS6110136A (ja) * | 1984-06-25 | 1986-01-17 | Fumio Itatsu | 油圧機器の圧力調整装置 |
| JPS6134832A (ja) * | 1984-07-26 | 1986-02-19 | Hitachi Ltd | 大口径イオン源 |
| JPS6133593A (ja) * | 1984-07-26 | 1986-02-17 | 株式会社東芝 | 防犯装置 |
| US4604346A (en) * | 1984-10-09 | 1986-08-05 | Massachusetts Institute Of Technology | Skin-equivalent prepared by the use of punch biopsy |
| US4760020A (en) * | 1985-05-03 | 1988-07-26 | Eye Research Institute Of Retina Foundation | Method for testing biocompatibility |
-
1987
- 1987-03-31 US US07/032,848 patent/US4835102A/en not_active Expired - Lifetime
-
1988
- 1988-03-01 IL IL85599A patent/IL85599A/xx not_active IP Right Cessation
- 1988-03-30 CA CA000562955A patent/CA1305913C/en not_active Expired - Lifetime
- 1988-03-31 ES ES88302953T patent/ES2106010T3/es not_active Expired - Lifetime
- 1988-03-31 EP EP88302953A patent/EP0295762B1/en not_active Expired - Lifetime
- 1988-03-31 AT AT88302953T patent/ATE156915T1/de not_active IP Right Cessation
- 1988-03-31 DE DE3855991T patent/DE3855991T2/de not_active Expired - Fee Related
- 1988-03-31 JP JP63076647A patent/JP2767803B2/ja not_active Expired - Lifetime
-
1997
- 1997-10-15 GR GR970402692T patent/GR3025046T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL85599A0 (en) | 1988-08-31 |
| EP0295762A2 (en) | 1988-12-21 |
| EP0295762A3 (en) | 1990-07-04 |
| DE3855991T2 (de) | 1998-01-22 |
| IL85599A (en) | 1991-11-21 |
| EP0295762B1 (en) | 1997-08-13 |
| DE3855991D1 (de) | 1997-09-18 |
| CA1305913C (en) | 1992-08-04 |
| ATE156915T1 (de) | 1997-08-15 |
| GR3025046T3 (en) | 1998-01-30 |
| JP2767803B2 (ja) | 1998-06-18 |
| US4835102A (en) | 1989-05-30 |
| JPS63296699A (ja) | 1988-12-02 |
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