ES2147556T3 - Proteina relativa al hueso, del tipo carboxipeptidasa y procedimiento para su produccion. - Google Patents

Proteina relativa al hueso, del tipo carboxipeptidasa y procedimiento para su produccion.

Info

Publication number
ES2147556T3
ES2147556T3 ES93113604T ES93113604T ES2147556T3 ES 2147556 T3 ES2147556 T3 ES 2147556T3 ES 93113604 T ES93113604 T ES 93113604T ES 93113604 T ES93113604 T ES 93113604T ES 2147556 T3 ES2147556 T3 ES 2147556T3
Authority
ES
Spain
Prior art keywords
bone
osf
protein
carboxipeptidase
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93113604T
Other languages
English (en)
Inventor
Shinji Kawai
Sunao Takeshita
Makoto Okazaki
Egon Dr Amann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOECHST MARION ROUSSEL Ltd
Sanofi Aventis KK
Original Assignee
HOECHST MARION ROUSSEL Ltd
Nippon Hoechst Marion Roussel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HOECHST MARION ROUSSEL Ltd, Nippon Hoechst Marion Roussel Ltd filed Critical HOECHST MARION ROUSSEL Ltd
Application granted granted Critical
Publication of ES2147556T3 publication Critical patent/ES2147556T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Woven Fabrics (AREA)

Abstract

UNA PROTEINA COMO CARBOXIPEPTIDASA AFIN A HUESOS, DENOMINADA OSF-5, QUE SE OBTIENE DEL TEJIDO OSEO DE UN MAMIFERO, INCLUYENDO RATON O GENERO HUMANO, Y UN PROCESO PARA SU PRODUCCION. ESTA PROTEINA ES UNA NUEVA PROTEINA QUE SE DA CON NATURALIDAD EN LOS MAMIFEROS, Y QUE PERTENECE A UN GRUPO DE MOLECULAS DE CARBOXIPEPTIDASA. OSF-5 ACTUA COMO UNA MOLECULA DE ADHESION O UN FACTOR DE CRECIMIENTO, QUE TOMA PARTE EN EL PROCESO DE OSTEOGENESIS EN EL LADO DE LA INDUCCION OSEA. OSF-5. OSF-5 PUEDE USARSE COMO UN AGENTE PARA TRATAR LAS ENFERMEDADES METABOLICAS OSEAS, Y SU ALTA CALIDAD DE ESPECIFICO DE ORGANOS PARA HUESOS FACULTA SU USO COMO UN REACTIVO DE DIAGNOSTICO PARA ENFERMEDADES METABOLICAS OSEAS.
ES93113604T 1992-08-28 1993-08-25 Proteina relativa al hueso, del tipo carboxipeptidasa y procedimiento para su produccion. Expired - Lifetime ES2147556T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23002992 1992-08-28
JP32403392A JP3472587B2 (ja) 1992-08-28 1992-12-03 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法

Publications (1)

Publication Number Publication Date
ES2147556T3 true ES2147556T3 (es) 2000-09-16

Family

ID=26529108

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93113604T Expired - Lifetime ES2147556T3 (es) 1992-08-28 1993-08-25 Proteina relativa al hueso, del tipo carboxipeptidasa y procedimiento para su produccion.

Country Status (10)

Country Link
US (1) US5460951A (es)
EP (1) EP0588118B1 (es)
JP (1) JP3472587B2 (es)
AT (1) ATE192495T1 (es)
AU (1) AU663217B2 (es)
CA (1) CA2104998A1 (es)
DE (1) DE69328527T2 (es)
DK (1) DK0588118T3 (es)
ES (1) ES2147556T3 (es)
PT (1) PT588118E (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06121678A (ja) * 1992-08-28 1994-05-06 Hoechst Japan Ltd 骨関連サルファターゼ様タンパク質およびその製造法
JP3560252B2 (ja) * 1992-08-28 2004-09-02 アベンティス ファーマ株式会社 骨関連カドヘリン様タンパク質およびその製造法
JPH06256210A (ja) * 1993-03-10 1994-09-13 Hoechst Japan Ltd 骨関連転写制御因子様タンパク質およびその製造法
IL116696A (en) * 1995-01-25 1999-08-17 Bio Technology General Corp Production of enzymatically active recombinant carboxypeptidase b
WO1997033900A1 (en) * 1996-03-15 1997-09-18 President And Fellows Of Harvard College E2a-binding protein
US6468766B1 (en) 1996-03-15 2002-10-22 President And Fellows Of Harvard College Aortic carboxypeptidase-like polypeptide
WO1998029453A1 (en) * 1996-12-27 1998-07-09 Mochida Pharmaceutical Co., Ltd. Cell membrane-directed drugs
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6420155B1 (en) * 1999-10-14 2002-07-16 Curagen Corporation Aortic carboxypeptidase-like protein and nucleic acids encoding same
DE60135339D1 (de) * 2000-05-16 2008-09-25 Millenium Pharmaceuticals Inc Behandlungsverfahren unter verwendung von 17906 und dessen anwendungen
KR20010000464A (ko) * 2000-10-02 2001-01-05 김철주 골다공증 진단용 단백질칩
US20040081653A1 (en) * 2002-08-16 2004-04-29 Raitano Arthur B. Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
CN1863928A (zh) 2003-08-08 2006-11-15 英特利金遗传学有限公司 骨质疏松的诊断和治疗

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06121678A (ja) * 1992-08-28 1994-05-06 Hoechst Japan Ltd 骨関連サルファターゼ様タンパク質およびその製造法
DE4228839A1 (de) * 1992-08-29 1994-03-03 Behringwerke Ag Verfahren zum Nachweis und zur Bestimmung von Mediatoren

Also Published As

Publication number Publication date
AU4492393A (en) 1994-03-03
AU663217B2 (en) 1995-09-28
EP0588118A3 (en) 1995-01-11
JP3472587B2 (ja) 2003-12-02
DE69328527T2 (de) 2001-01-11
JPH06121682A (ja) 1994-05-06
DE69328527D1 (de) 2000-06-08
CA2104998A1 (en) 1994-03-01
EP0588118B1 (en) 2000-05-03
DK0588118T3 (da) 2000-10-02
PT588118E (pt) 2000-09-29
EP0588118A2 (en) 1994-03-23
US5460951A (en) 1995-10-24
ATE192495T1 (de) 2000-05-15

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