ES2106735T3 - Tratamiento de desordenes mediante la aplicacion de factores de crecimiento de tipo de insulina y analogos. - Google Patents
Tratamiento de desordenes mediante la aplicacion de factores de crecimiento de tipo de insulina y analogos.Info
- Publication number
- ES2106735T3 ES2106735T3 ES90909874T ES90909874T ES2106735T3 ES 2106735 T3 ES2106735 T3 ES 2106735T3 ES 90909874 T ES90909874 T ES 90909874T ES 90909874 T ES90909874 T ES 90909874T ES 2106735 T3 ES2106735 T3 ES 2106735T3
- Authority
- ES
- Spain
- Prior art keywords
- insulin
- analogs
- disorders
- treatment
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 239000003102 growth factor Substances 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 2
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 abstract 2
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 1
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN METODO PARA POTENCIAR LA SUPERVIVENCIA DE CELULAS NEURONALES EN UN MAMIFERO, CUANDO LAS CELULAS ESTEN EN RIESGO DE MORIR. EL METODO COMPRENDE LA ADMINISTRACION AL MAMIFERO DE UNA CANTIDAD EFECTIVA DE AL MENOS UNA DE LAS SIGUIENTES SUSTANCIAS: IGF-I; UN DERIVADO FUNCIONAL DE IGF-I; IGF-II; O UN DERIVADO FUNCIONAL DE IGF-II, SIEMPRE QUE IGF-I O IGF-II SEAN ADMINISTRADOS Y QUE NGF O UN DERIVADO FUNCIONAL DE NGF SEA TAMBIEN ADMINISTRADO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/361,595 US5093317A (en) | 1989-06-05 | 1989-06-05 | Treating disorders by application of insulin-like growth factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2106735T3 true ES2106735T3 (es) | 1997-11-16 |
Family
ID=23422661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90909874T Expired - Lifetime ES2106735T3 (es) | 1989-06-05 | 1990-06-05 | Tratamiento de desordenes mediante la aplicacion de factores de crecimiento de tipo de insulina y analogos. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5093317A (es) |
| EP (2) | EP0798000A3 (es) |
| JP (1) | JPH0768138B2 (es) |
| AT (1) | ATE156018T1 (es) |
| CA (1) | CA2058443C (es) |
| DE (1) | DE69031168T2 (es) |
| DK (1) | DK0476044T3 (es) |
| ES (1) | ES2106735T3 (es) |
| WO (1) | WO1990014838A1 (es) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440928B1 (en) | 1988-12-06 | 2002-08-27 | Colorado State University Research Foundation | Method for treating diabetic neuropathy with NGF |
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| US5652214A (en) * | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US6723699B1 (en) * | 1989-06-05 | 2004-04-20 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US5792831A (en) * | 1990-02-08 | 1998-08-11 | Magainin Pharmaceuticals Inc. | Analogues of magainin peptides containing D-amino acids |
| US5616562A (en) * | 1990-04-27 | 1997-04-01 | Murphy; Christopher J. | Methods and compositions using substance P to promote wound healing |
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| US5633230A (en) * | 1990-10-24 | 1997-05-27 | Allelix Biopharmaceuticals, Inc. | Treatment of cytomegalovirus infection |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
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| SE9101341D0 (sv) * | 1991-05-03 | 1991-05-03 | Kabi Pharmacia Ab | New medicinal use |
| DE69218948T2 (de) * | 1991-08-01 | 1997-07-31 | Auckland Uniservices Ltd | IGF-I zur Verbesserung der neuronale Lage |
| US5861373A (en) * | 1991-08-01 | 1999-01-19 | Genentech, Inc | IGF-1 to improve the neural condition |
| US5298422A (en) * | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
| US5925564A (en) * | 1991-11-06 | 1999-07-20 | Baylor College Of Medicine | Expression vector systems and method of use |
| US6310040B1 (en) * | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
| US6204240B1 (en) * | 1991-11-22 | 2001-03-20 | Genentech, Inc. | TGF-β1 to improve neural outcome |
| WO1993010806A1 (en) * | 1991-11-25 | 1993-06-10 | Institute Of Molecular Biology, Inc. | Medicament for promoting growth of mammalian nerve |
| US5281582A (en) * | 1992-02-27 | 1994-01-25 | Alliance Pharmaceuticals, Corp. | Serum growth factor |
| AU4238493A (en) * | 1992-05-08 | 1993-12-13 | Thomas Jefferson University | IGF-1 analogs |
| NZ253867A (en) * | 1992-06-12 | 1996-08-27 | Cephalon Inc | Treating peripheral neuropathy using igf-1 or igf-3 |
| US20070078089A1 (en) * | 1992-07-06 | 2007-04-05 | Ishii Douglas N | Method for effecting changes in the central nervous system by administration of IGF-I or IGF-II |
| CA2155540A1 (en) * | 1993-02-08 | 1994-08-18 | Frank Collins | Methods for treating amyotrophic lateral sclerosis with cntf |
| JPH09509140A (ja) * | 1993-11-15 | 1997-09-16 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 神経学的障害の治療方法 |
| AU1439095A (en) * | 1993-12-15 | 1995-07-03 | Thomas Jefferson University | Igf-1 analogs |
| US5629286A (en) * | 1994-03-31 | 1997-05-13 | Brewitt; Barbara | Homeopathic dilutions of growth factors |
| US5444047A (en) * | 1994-06-16 | 1995-08-22 | Dipasquale; Gene | Treatment of arthritic and post-surgical orthopedic conditions with Insulin-like Growth Factor-I |
| US5716614A (en) * | 1994-08-05 | 1998-02-10 | Molecular/Structural Biotechnologies, Inc. | Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier |
| US5728676A (en) * | 1994-09-08 | 1998-03-17 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
| US5650496A (en) | 1995-04-14 | 1997-07-22 | Cephalon, Inc. | IGF-I purification process |
| US6756484B1 (en) | 1995-04-14 | 2004-06-29 | Cephalon, Inc. | IGF-I purification process |
| US5565428A (en) * | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
| US5741776A (en) * | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
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| US5798715A (en) * | 1996-06-28 | 1998-08-25 | Saperstone; Dorothy Luhr | Method and device for accessing remote control functions |
| US6514937B1 (en) | 1997-02-25 | 2003-02-04 | Celtrix Pharmaceuticals, Inc. | Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3 |
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| ES2146530B1 (es) * | 1997-12-26 | 2001-04-16 | Consejo Superior Investigacion | Utilizacion del factor de crecimiento igf-i en la fabricacion de composiciones utiles en el tratamiento de la ataxia cerebelar. |
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| US7118752B2 (en) * | 1998-07-22 | 2006-10-10 | University Of Connecticut | Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I |
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| EP1982732A3 (en) | 2000-02-11 | 2011-06-08 | Bayer HealthCare LLC | Factor VII or VIIA-like conjugates |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7812132B2 (en) | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| AU2001288443B2 (en) * | 2000-08-29 | 2007-06-07 | Aurogen Inc. | Method for treating the central nervous system by administration of IGF structural analogs |
| US20020082215A1 (en) * | 2000-10-13 | 2002-06-27 | Chiron Corporation | Method for treating ischemic events affecting the central nervous system |
| AU2002246619A1 (en) * | 2000-12-08 | 2003-06-23 | Neuronz Limited | Use of insuline-like growth factor-i for promoting remyelination of axons |
| CN100439397C (zh) * | 2001-02-09 | 2008-12-03 | 基因技术股份有限公司 | Igf-1的结晶 |
| US7605177B2 (en) * | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
| ATE435852T1 (de) | 2001-05-24 | 2009-07-15 | Neuren Pharmaceuticals Ltd | Gpe-analoga und peptidomimetika |
| US20070004641A1 (en) * | 2001-05-24 | 2007-01-04 | Neuren Pharmaceuticals Limited | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate |
| US7714020B2 (en) * | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
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| JP4253743B2 (ja) * | 2001-12-03 | 2009-04-15 | 輝夫 西田 | 新規ペプチドおよびその医薬用途 |
| ES2207387B1 (es) * | 2002-02-28 | 2005-07-16 | Consejo Sup. Investig. Cientificas | Composicion quimica de igf-i para el tratamiento y prevencion de enfermedades neurodegenerativas. |
| US7700733B2 (en) * | 2002-04-30 | 2010-04-20 | Bayer Healthcare Llc | Factor VII or VIIa polypeptide variants |
| EP1549677B1 (en) * | 2002-09-30 | 2011-04-13 | Bayer HealthCare LLC | FVII OR FVIIa VARIANTS HAVING INCREASED CLOTTING ACTIVITY |
| US20040176704A1 (en) * | 2003-03-04 | 2004-09-09 | Stevens Timothy A | Collection device adapted to accept cartridge for point of care system |
| DK2085470T3 (da) * | 2003-03-20 | 2012-08-06 | Bayer Healthcare Llc | FVII- eller FVIIa-varianter |
| DK1644504T3 (da) * | 2003-06-19 | 2010-05-25 | Bayer Healthcare Llc | Faktor VII- eller -VIIA-Gla-domænevarianter |
| EP1791551B1 (en) * | 2004-08-30 | 2020-02-26 | Ipsen Biopharmaceuticals, Inc. | Method and device for diagnosing and treating insulin-like growth factor deficiency disorders |
| US20060069008A1 (en) * | 2004-09-28 | 2006-03-30 | Sanjay Mistry | Treatment of neurological deficits in the striatum or substanta nigra pars compacta |
| US20060069009A1 (en) * | 2004-09-28 | 2006-03-30 | Messina Darin J | Treatment of neurological deficits in the striatum or substanta nigra pars compacta |
| US20090012499A1 (en) * | 2005-02-08 | 2009-01-08 | Japan As Rep. By Pres. Of Nat. Cardiovascular Ctr. | Novel method for treating chronic severe heart failure by using insulin-like growth factor-1 (igf-1) |
| JP2008533114A (ja) * | 2005-03-18 | 2008-08-21 | ユーシーエル ビジネス パブリック リミテッド カンパニー | メカノ成長因子ペプチドおよびその使用 |
| CL2007002502A1 (es) * | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
| ES2322685B2 (es) * | 2006-11-21 | 2010-03-15 | Universidad De Malaga | Utilizacion de dosis bajas de igf-ii en el envejecimiento por sus efectos neuroprotectores y hepatoprotectores. |
| US7994127B2 (en) * | 2007-06-08 | 2011-08-09 | Massachusetts Institute Of Technology | Treatment of rett syndrome |
| AU2009231394B2 (en) * | 2008-04-03 | 2013-09-05 | F. Hoffmann-La Roche Ag | Use of PEGylated IGF-I variants for the treatment of neuromuscular disorders |
| TWI541020B (zh) | 2008-04-17 | 2016-07-11 | 巴克斯歐塔公司 | 生物活性胜肽 |
| JP6983069B2 (ja) | 2014-10-20 | 2021-12-17 | ニューラルステム, インコーポレイテッド | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
| WO2016184427A1 (zh) * | 2015-05-21 | 2016-11-24 | 中国科学院上海生命科学研究院 | 低氧处理的间充质干细胞及其应用 |
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| SE8703625D0 (sv) * | 1987-09-18 | 1987-09-18 | Kabivitrum Ab | New medical use |
| CA1338337C (en) * | 1988-09-27 | 1996-05-21 | Health Foundation Limited (The) | Method and composition for the treatment of burns |
| WO1991002067A1 (en) * | 1989-07-27 | 1991-02-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Regulation of nerve growth factor synthesis in the central nervous system |
-
1989
- 1989-06-05 US US07/361,595 patent/US5093317A/en not_active Expired - Lifetime
-
1990
- 1990-06-05 CA CA002058443A patent/CA2058443C/en not_active Expired - Lifetime
- 1990-06-05 ES ES90909874T patent/ES2106735T3/es not_active Expired - Lifetime
- 1990-06-05 WO PCT/US1990/003166 patent/WO1990014838A1/en not_active Ceased
- 1990-06-05 AT AT90909874T patent/ATE156018T1/de not_active IP Right Cessation
- 1990-06-05 EP EP97200539A patent/EP0798000A3/en not_active Withdrawn
- 1990-06-05 DE DE69031168T patent/DE69031168T2/de not_active Expired - Lifetime
- 1990-06-05 EP EP90909874A patent/EP0476044B1/en not_active Expired - Lifetime
- 1990-06-05 DK DK90909874.1T patent/DK0476044T3/da active
- 1990-06-05 JP JP2509846A patent/JPH0768138B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5093317A (en) | 1992-03-03 |
| EP0476044B1 (en) | 1997-07-30 |
| DE69031168T2 (de) | 1997-12-04 |
| DK0476044T3 (da) | 1997-11-17 |
| HK1010989A1 (en) | 1999-07-02 |
| DE69031168D1 (de) | 1997-09-04 |
| CA2058443A1 (en) | 1990-12-06 |
| EP0798000A3 (en) | 1998-01-14 |
| EP0798000A2 (en) | 1997-10-01 |
| EP0476044A4 (en) | 1992-07-01 |
| ATE156018T1 (de) | 1997-08-15 |
| WO1990014838A1 (en) | 1990-12-13 |
| JPH0768138B2 (ja) | 1995-07-26 |
| JPH04507240A (ja) | 1992-12-17 |
| EP0476044A1 (en) | 1992-03-25 |
| CA2058443C (en) | 1998-11-03 |
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