GR3025995T3 - N-alkyl-2-substituted atp analogues. - Google Patents

N-alkyl-2-substituted atp analogues.

Info

Publication number
GR3025995T3
GR3025995T3 GR980400166T GR980400166T GR3025995T3 GR 3025995 T3 GR3025995 T3 GR 3025995T3 GR 980400166 T GR980400166 T GR 980400166T GR 980400166 T GR980400166 T GR 980400166T GR 3025995 T3 GR3025995 T3 GR 3025995T3
Authority
GR
Greece
Prior art keywords
alkyl
independently represent
halogen
phenyl
atp analogues
Prior art date
Application number
GR980400166T
Other languages
English (en)
Inventor
Anthony Howard Ingall
Peter Alan Cage
Nicholas David Kindon
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939302636A external-priority patent/GB9302636D0/en
Priority claimed from GB939325712A external-priority patent/GB9325712D0/en
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Publication of GR3025995T3 publication Critical patent/GR3025995T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GR980400166T 1993-02-10 1998-01-26 N-alkyl-2-substituted atp analogues. GR3025995T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939302636A GB9302636D0 (en) 1993-02-10 1993-02-10 Compounds
GB939325712A GB9325712D0 (en) 1993-12-16 1993-12-16 Compounds
PCT/GB1994/000237 WO1994018216A1 (en) 1993-02-10 1994-02-08 N-alkyl-2-substituted atp analogues

Publications (1)

Publication Number Publication Date
GR3025995T3 true GR3025995T3 (en) 1998-04-30

Family

ID=26302434

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400166T GR3025995T3 (en) 1993-02-10 1998-01-26 N-alkyl-2-substituted atp analogues.

Country Status (26)

Country Link
US (2) US5721219A (el)
EP (1) EP0683789B1 (el)
JP (1) JP3083156B2 (el)
KR (1) KR100315612B1 (el)
CN (1) CN1042430C (el)
AT (1) ATE159950T1 (el)
AU (1) AU679721B2 (el)
CA (1) CA2155673C (el)
CZ (1) CZ286050B6 (el)
DE (1) DE69406649T2 (el)
DK (1) DK0683789T3 (el)
ES (1) ES2108425T3 (el)
FI (1) FI110687B (el)
GR (1) GR3025995T3 (el)
HK (1) HK1002936A1 (el)
HU (1) HU221501B (el)
IL (1) IL108602A (el)
NO (1) NO305209B1 (el)
NZ (1) NZ261159A (el)
PL (1) PL175623B1 (el)
RU (1) RU2136693C1 (el)
SG (1) SG47943A1 (el)
SK (1) SK281309B6 (el)
TW (1) TW326045B (el)
UA (1) UA54366C2 (el)
WO (1) WO1994018216A1 (el)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK281309B6 (sk) * 1993-02-10 2001-02-12 Astra Pharmaceuticals Limited N-alkyl-2-substituované adenozíntrifosfátové deriváty, spôsob ich prípravy, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov
WO1998018430A2 (en) * 1996-10-30 1998-05-07 The University Of North Carolina At Chapel Hill P2y receptor antagonists
ID21635A (id) * 1996-12-20 1999-07-08 Astra Pharma Prod Komposisi farmasi untuk pengeringan beku
US6686462B2 (en) * 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
SE9702680D0 (sv) * 1997-07-11 1997-07-11 Astra Pharma Prod New formulation
AU2003257524B2 (en) * 1997-07-11 2006-04-06 Astrazeneca Ab New formulation
FI104901B (fi) * 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US7598246B2 (en) * 1998-04-02 2009-10-06 Mbc Pharma, Inc. Bisphosphonate conjugates and methods of making and using the same
US6750340B2 (en) * 1998-04-02 2004-06-15 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US6303774B1 (en) 1999-08-20 2001-10-16 Sri International Nucleoside pyrophosphate and triphosphate analogs and related compounds
SE9903345D0 (sv) 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7115585B2 (en) 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7452870B2 (en) 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
AR039558A1 (es) * 2000-08-21 2005-02-23 Inspire Pharmaceuticals Inc Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US7435724B2 (en) 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
US7285658B2 (en) * 2002-02-28 2007-10-23 Biota, Inc. Nucleotide mimics and their prodrugs
US20050192245A1 (en) * 2002-07-18 2005-09-01 Sankyo Company, Limited Medicinal composition for treating arteriosclerosis
CN1681533A (zh) * 2002-07-18 2005-10-12 三共株式会社 用于治疗动脉硬化的药用组合物
US8222229B2 (en) 2002-11-21 2012-07-17 Kowa Co., Ltd. Peritoneal dialysis method
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
EP1604669A1 (en) * 2004-06-10 2005-12-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of ATP analogues for treatment of cardiovascular diseases
US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
US20130303477A1 (en) * 2008-05-13 2013-11-14 The Medicines Company Maintenance of Platelet Inhibition During Antiplatelet Therapy
WO2009140092A1 (en) 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US20120141468A1 (en) 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
US8759316B2 (en) * 2008-05-13 2014-06-24 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
BR112012011298B1 (pt) * 2009-11-11 2021-12-14 Chiesi Farmaceutici S.P.A. Uso de cangrelor e/ou bivalirudina na preparação de medicamentos e combinação de medicamentos
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
EP2669292B1 (en) * 2011-01-26 2017-03-29 Beijing KBD Pharmaceuticals Co., Ltd. Ribofuranosyl purine compounds for treating diseases associated with platelet aggregation
WO2012109406A1 (en) 2011-02-09 2012-08-16 The Medicines Company Methods for treating pulmonary hypertension
CA2843885C (en) 2011-08-01 2020-03-10 Mbc Pharma, Inc. Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
AU2013381855B2 (en) 2013-03-09 2018-08-02 Chiesi Farmaceutici S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
CN104447927A (zh) * 2013-09-13 2015-03-25 天津市汉康医药生物技术有限公司 坎格雷洛一水合物晶体及其制备方法
CN104447928A (zh) * 2013-09-13 2015-03-25 天津市汉康医药生物技术有限公司 坎格雷洛二水化合物
CN103772461A (zh) * 2014-01-06 2014-05-07 南京正科制药有限公司 一种坎格雷洛晶型ⅰ
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN105273025B (zh) * 2014-07-22 2019-07-26 上海医药工业研究院 一种制备坎格雷洛的中间体及其制备方法和应用
MA41326A (fr) 2015-01-14 2021-04-28 Chiesi Farm Spa Formulations pharmaceutiques comprenant du cangrelor de haute pureté et leurs procédés de préparation et d'utilisation
CN105061431B (zh) * 2015-07-28 2017-03-29 山东百诺医药股份有限公司 6‑n‑（2‑（甲硫基）乙基）‑2‑（（3,3,3‑三氟丙基）硫代）‑9h‑嘌呤及其制备方法和应用
WO2017076266A1 (zh) * 2015-11-06 2017-05-11 江苏恒瑞医药股份有限公司 制备坎格雷洛中间体的方法
CN107973798B (zh) * 2016-10-25 2020-04-24 上海医药工业研究院 2-[(3,3,3-三氟丙基)硫代]-6-氨基-9h-嘌呤及制法
CN107973832B (zh) * 2016-10-25 2021-11-12 上海医药工业研究院 6-n-[2-(甲硫基)乙基]-2-[(3，3，3-三氟丙基)硫代]腺苷的制法
CN106674322B (zh) * 2016-12-07 2019-04-16 上海博志研新药物技术有限公司 一种坎格雷洛中间体的纯化方法
WO2018185715A1 (en) * 2017-04-06 2018-10-11 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of n6-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5'-adenylic acid, monoanhydride with (dichloromethylene) bisphosphonic acid and its pharmaceutically acceptable salts
WO2018234565A1 (en) 2017-06-23 2018-12-27 Chiesi Farmaceutici S.P.A. METHOD FOR PREVENTING SHUNT THROMBOSIS FROM THE SYSTEMIC-PULMONARY ARTERY
US11279724B2 (en) 2017-11-10 2022-03-22 Olon S.P.A. Efficient method for the preparation of Cangrelor
CN109912674A (zh) * 2017-12-12 2019-06-21 亚宝药业集团股份有限公司 一种坎格雷洛四钠盐的制备方法
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
US20190241606A1 (en) * 2018-02-05 2019-08-08 Scinopharm Taiwan, Ltd. Process for preparation of cangrelor tetrasodium and intermediate therefor
CN108033983B (zh) * 2018-02-09 2021-06-08 盐城锦明药业有限公司 一种2‐(3,3,3‐三氟丙基)硫代腺苷的合成方法
EP4289435A1 (en) 2022-06-07 2023-12-13 Université de Liège N-alkyl-2-substituted atp analogues for use as antibacterial agent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU764326A1 (ru) * 1977-11-16 1982-09-23 Ордена Ленина Институт Химической Физики Ан Ссср Способ получени спин-меченого производного аденозинтрифосфата
US5049550A (en) * 1987-11-05 1991-09-17 Worcester Foundation For Experimental Biology Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents
WO1990011080A1 (en) * 1989-03-24 1990-10-04 Daiichi Pharmaceutical Co., Ltd. Drug for improving brain function
GB9107236D0 (en) 1991-04-06 1991-05-22 Fisons Plc Compounds
DE69204717T2 (de) * 1991-04-06 1996-04-25 Astra Pharmaceuticals Limited, Kings Langley, Herts ATP-Analogen.
SK281309B6 (sk) * 1993-02-10 2001-02-12 Astra Pharmaceuticals Limited N-alkyl-2-substituované adenozíntrifosfátové deriváty, spôsob ich prípravy, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov

Also Published As

Publication number Publication date
FI953794L (fi) 1995-08-10
PL175623B1 (pl) 1999-01-29
ES2108425T3 (es) 1997-12-16
JPH08506335A (ja) 1996-07-09
CZ203295A3 (en) 1995-12-13
NO953126D0 (no) 1995-08-09
EP0683789B1 (en) 1997-11-05
IL108602A0 (en) 1994-05-30
KR100315612B1 (ko) 2002-06-20
NO953126L (no) 1995-09-28
NZ261159A (en) 1997-06-24
HU221501B (en) 2002-10-28
IL108602A (en) 1999-12-22
SG47943A1 (en) 1998-04-17
ATE159950T1 (de) 1997-11-15
NO305209B1 (no) 1999-04-19
US5955447A (en) 1999-09-21
AU679721B2 (en) 1997-07-10
CZ286050B6 (cs) 1999-12-15
CA2155673A1 (en) 1994-08-18
DK0683789T3 (da) 1998-02-09
US5721219A (en) 1998-02-24
HK1002936A1 (en) 1998-09-25
HUT72464A (en) 1996-04-29
UA54366C2 (uk) 2003-03-17
CA2155673C (en) 2004-08-17
SK99495A3 (en) 1996-02-07
CN1042430C (zh) 1999-03-10
TW326045B (en) 1998-02-01
SK281309B6 (sk) 2001-02-12
RU2136693C1 (ru) 1999-09-10
DE69406649D1 (de) 1997-12-11
FI953794A0 (fi) 1995-08-10
DE69406649T2 (de) 1998-03-05
AU5977094A (en) 1994-08-29
JP3083156B2 (ja) 2000-09-04
WO1994018216A1 (en) 1994-08-18
FI110687B (fi) 2003-03-14
EP0683789A1 (en) 1995-11-29
PL310160A1 (en) 1995-11-27
CN1119869A (zh) 1996-04-03

Similar Documents

Publication Publication Date Title
SG47943A1 (en) N-alkyl-2-substituted atp analogues
GB9211172D0 (en) Compounds
ZA919181B (en) Oxazolopyridine derivatives,processes for preparing these and pharmaceutical compositions containing them
HUP9802822A2 (hu) Halogén-benzimidazol-származékok, intermedierjeik, előállításuk és a vegyületeket hatóanyagként tartalmazó mikrobicid készítmények
DE69831499D1 (de) Inhibitoren des nukleosid-metabolismus
PL308666A1 (en) Derivatives of 11,21-bisphenyl-19-norpregnan, method of obtaining them and pharmaceutical composition containing such derivatives
DE69330601D1 (de) Serotoninergische ergolin derivate
ES467069A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1-3-bencenodimetanol
HUP0204217A2 (en) Novel a-500359 derivatives
AU639154B2 (en) New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them
GR3037045T3 (en) Pseudopeptides derived from neurokinines, process of preparation and pharmaceutical compositions comprising them
JO1825B1 (en) Therapeutic agents
MX9708525A (es) Derivados de vinilpirrolidinon-cefalosporina.