ES2108732T3 - Anticuerpos humanizados anti-globulos de la grasa de la leche humana. - Google Patents

Anticuerpos humanizados anti-globulos de la grasa de la leche humana.

Info

Publication number
ES2108732T3
ES2108732T3 ES92308680T ES92308680T ES2108732T3 ES 2108732 T3 ES2108732 T3 ES 2108732T3 ES 92308680 T ES92308680 T ES 92308680T ES 92308680 T ES92308680 T ES 92308680T ES 2108732 T3 ES2108732 T3 ES 2108732T3
Authority
ES
Spain
Prior art keywords
humanized antibodies
hams
human milk
balloons
milk fat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92308680T
Other languages
English (en)
Inventor
John Robert Adair
Philip R Hamann
Raymond John Owens
Terence Seward Baker
Alan Howard Lyons
Lois M Hinman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celltech R&D Ltd
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Application granted granted Critical
Publication of ES2108732T3 publication Critical patent/ES2108732T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBEN MOLECULAS DE ANTICUERPOS HUMANIZADOS (HAMS) QUE PRESENTAN UNA ESPECIFICIDAD HACIA LOS GLOBULOS GRASOS DE LA LECHE HUMANA Y QUE TIENEN UN LUGAR DE ENLACE ANTIGENO EN DONDE AL MENOS UNA DE LAS REGIONES DETERMINANTES DE LA COMPLEMENTARIEDAD (CDRS) DE LOS DOMINIOS VARIABLES SE DERIVA DEL ANTICUERPO MONOCLONAL DEL RATON CTMO1 Y LAS PARTES DERIVADAS DE LA INMUNOGLOBULINA RESTANTES DE LA HAM SE DERIVAN DE UNA INMUNOGLOBULINA HUMANA. LAS HAMS PUEDEN SER ANTICUERPOS HUMANIZADOS QUIMERICOS O ANTICUERPOS HUMANIZADOS CON UN INJERTO CDR Y SE PRODUCEN PREFERENTEMENTE MEDIANTE TECNICAS DEL ADN RECOMBINANTE. LAS HAMS SE PUEDEN CONJUGAR CON UNA MOLECULA EFECTORA O REPORTERA, EN PARTICULAR AGENTES ANTITUMORES DE METILTRITIO, Y SON UTILES PARA UN DIAGNOSTICO Y UNA TERAPIA IN VIVO.
ES92308680T 1991-09-26 1992-09-24 Anticuerpos humanizados anti-globulos de la grasa de la leche humana. Expired - Lifetime ES2108732T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919120467A GB9120467D0 (en) 1991-09-26 1991-09-26 Anti-hmfg antibodies and process for their production

Publications (1)

Publication Number Publication Date
ES2108732T3 true ES2108732T3 (es) 1998-01-01

Family

ID=10701993

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92308680T Expired - Lifetime ES2108732T3 (es) 1991-09-26 1992-09-24 Anticuerpos humanizados anti-globulos de la grasa de la leche humana.

Country Status (13)

Country Link
US (1) US6506881B1 (es)
EP (2) EP0781845B1 (es)
JP (1) JP3498957B2 (es)
AT (2) ATE160362T1 (es)
AU (1) AU666868B2 (es)
CA (1) CA2095926C (es)
DE (2) DE69232991T2 (es)
DK (1) DK0781845T3 (es)
ES (1) ES2108732T3 (es)
GB (1) GB9120467D0 (es)
IL (1) IL103269A (es)
NZ (1) NZ244468A (es)
WO (1) WO1993006231A1 (es)

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Also Published As

Publication number Publication date
DK0781845T3 (da) 2003-06-16
CA2095926A1 (en) 1993-03-27
DE69223206D1 (de) 1998-01-02
EP0781845A2 (en) 1997-07-02
ATE160362T1 (de) 1997-12-15
AU2598392A (en) 1993-04-27
NZ244468A (en) 1994-11-25
JPH06505399A (ja) 1994-06-23
EP0781845A3 (en) 1997-07-09
DE69232991D1 (de) 2003-05-08
IL103269A0 (en) 1993-02-21
DE69232991T2 (de) 2004-01-15
IL103269A (en) 1998-01-04
ATE236251T1 (de) 2003-04-15
CA2095926C (en) 2002-07-16
JP3498957B2 (ja) 2004-02-23
EP0781845B1 (en) 2003-04-02
AU666868B2 (en) 1996-02-29
WO1993006231A1 (en) 1993-04-01
EP0534742A1 (en) 1993-03-31
GB9120467D0 (en) 1991-11-06
EP0534742B1 (en) 1997-11-19
US6506881B1 (en) 2003-01-14
DE69223206T2 (de) 1998-06-25

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