ES2109595T3 - Procedimiento para la preparacion de un derivado de n-(fenil)-n-(4-piperidinil)amida. - Google Patents

Procedimiento para la preparacion de un derivado de n-(fenil)-n-(4-piperidinil)amida.

Info

Publication number
ES2109595T3
ES2109595T3 ES94202304T ES94202304T ES2109595T3 ES 2109595 T3 ES2109595 T3 ES 2109595T3 ES 94202304 T ES94202304 T ES 94202304T ES 94202304 T ES94202304 T ES 94202304T ES 2109595 T3 ES2109595 T3 ES 2109595T3
Authority
ES
Spain
Prior art keywords
preparation
fenyl
amida
piperidinyl
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94202304T
Other languages
English (en)
Inventor
William David Stuart Latham
Michael David Goodyear
Andrew Jonathan Whitehead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2109595T3 publication Critical patent/ES2109595T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DEL COMPUESTO DE FORMULA (I), UN INTERMEDIARIO UTIL PARA LA PREPARACION DE AGENTES ANALGESICOS; QUE COMPRENDE REACCIONAR UN COMPUESTO DE FORMULA (II) O UNA SAL DE ADICION ACIDA DEL MISMO CON ANHIDRIDO PROPIONICO Y DESPUES TRATAR EL PRODUCTO RESULTANTE CON METANOL
ES94202304T 1993-08-13 1994-08-11 Procedimiento para la preparacion de un derivado de n-(fenil)-n-(4-piperidinil)amida. Expired - Lifetime ES2109595T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939316863A GB9316863D0 (en) 1993-08-13 1993-08-13 Chemical process

Publications (1)

Publication Number Publication Date
ES2109595T3 true ES2109595T3 (es) 1998-01-16

Family

ID=10740452

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94202304T Expired - Lifetime ES2109595T3 (es) 1993-08-13 1994-08-11 Procedimiento para la preparacion de un derivado de n-(fenil)-n-(4-piperidinil)amida.

Country Status (10)

Country Link
US (1) US5599938A (es)
EP (1) EP0638554B1 (es)
JP (1) JP3429370B2 (es)
AT (1) ATE159519T1 (es)
DE (1) DE69406382T2 (es)
DK (1) DK0638554T3 (es)
ES (1) ES2109595T3 (es)
GB (1) GB9316863D0 (es)
GR (1) GR3025213T3 (es)
SG (1) SG52444A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866591A (en) * 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
JP2009515960A (ja) * 2005-11-17 2009-04-16 マリンクロッド・インコーポレイテッド レミフェンタニルの合成方法
US20080312448A1 (en) * 2006-01-24 2008-12-18 Cheng Brian K Process for Synthesizing Remifentanil
EP3199523B1 (en) 2016-01-29 2018-08-15 Bioka s. r.o. The new process for producing n-phenyl-n-(4-piperidinyl) amide derivatives such as remifentanil and carfentanil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179569A (en) * 1975-03-14 1979-12-18 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-N-phenylamides
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics

Also Published As

Publication number Publication date
ATE159519T1 (de) 1997-11-15
SG52444A1 (en) 1998-09-28
EP0638554B1 (en) 1997-10-22
DK0638554T3 (da) 1998-02-09
DE69406382D1 (de) 1997-11-27
DE69406382T2 (de) 1998-02-26
JPH07165713A (ja) 1995-06-27
GR3025213T3 (en) 1998-02-27
GB9316863D0 (en) 1993-09-29
US5599938A (en) 1997-02-04
JP3429370B2 (ja) 2003-07-22
EP0638554A1 (en) 1995-02-15

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