ES2110401T3 - Antibioticos pentapeptidicos derivados de dalbaheptidos. - Google Patents

Antibioticos pentapeptidicos derivados de dalbaheptidos.

Info

Publication number
ES2110401T3
ES2110401T3 ES90113139T ES90113139T ES2110401T3 ES 2110401 T3 ES2110401 T3 ES 2110401T3 ES 90113139 T ES90113139 T ES 90113139T ES 90113139 T ES90113139 T ES 90113139T ES 2110401 T3 ES2110401 T3 ES 2110401T3
Authority
ES
Spain
Prior art keywords
antibiotics
group
dalbaheptides
aminoacid
pentapeptidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90113139T
Other languages
English (en)
Inventor
Adriano Malabarba
Romeo Ciabatti
Juergen Kurt Kettenring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosearch Italia SpA
Original Assignee
Biosearch Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosearch Italia SpA filed Critical Biosearch Italia SpA
Application granted granted Critical
Publication of ES2110401T3 publication Critical patent/ES2110401T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

ANTIBIOTICOS PENTAPEPTIDOS DE FORMULA FIG EN LA QUE W, Z, X1, X2 Y T REPRESENTAN LAS PORCIONES RELATIVAS DE UN ANTIBIOTICO DEL GRUPO DALBAHEPTIDO (ANTIBIOTICOS GLICOPEPTIDOS), Y REPRESENTA UN GRUPO CARBOXIACIDO, UN DERIVADO FUNCIONAL DE DICHO GRUPO CARBOXIACIDO O U GRUPO HIDROMETIL. EL INVENTO INCLUYE LAS SALES DE LOS ANTIBIOTICOS PENTAPEPTIDOS NATES REPRESENTADOS CON LOS ACIDOS O BASES ASI COMO SUS SALES INTERNAS. LOS COMPUESTOS SE OBTIENEN MEDIANTE LA REACCION DE REDUCCION DEL ENLACE PEPTIDO ENTRE EL SEGUNDO Y TERCER AMINOACIDO DE LA CADENA DE 7 AMINOACIDOS DE DALBAHEPTIDOS (ANTIBIOTICOS GLICOPEPTIDOS). EL INVENTO TAMBIEN SE REFIERE AL PROCESO DE REACCION DE REDUCCION QUE IMPLICA EL USO DE UN BOROHIDRIDO METAL ALCALI COMO REAGENTE. EL COMPUESTO MUESTRA UNA ACTIVIDAD ANTIBACTERIANA CONTRA LOS ESTAFILOCOCOS Y LOS ESTREPTOCOCOS.
ES90113139T 1989-07-18 1990-07-10 Antibioticos pentapeptidicos derivados de dalbaheptidos. Expired - Lifetime ES2110401T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89113132 1989-07-18

Publications (1)

Publication Number Publication Date
ES2110401T3 true ES2110401T3 (es) 1998-02-16

Family

ID=8201636

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90113139T Expired - Lifetime ES2110401T3 (es) 1989-07-18 1990-07-10 Antibioticos pentapeptidicos derivados de dalbaheptidos.

Country Status (11)

Country Link
US (2) US5602229A (es)
EP (1) EP0409045B1 (es)
JP (1) JP2769028B2 (es)
KR (1) KR0145554B1 (es)
AT (1) ATE160360T1 (es)
CA (1) CA2021379C (es)
DE (1) DE69031721T2 (es)
DK (1) DK0409045T3 (es)
ES (1) ES2110401T3 (es)
GR (1) GR3025653T3 (es)
IE (1) IE902598A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE134379T1 (de) * 1990-12-05 1996-03-15 Lepetit Spa 38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung
DK0561827T3 (da) * 1990-12-10 1995-07-03 Lepetit Spa Tetrapeptider stammende fra dalbaheptidantibiotika
AU683881B2 (en) * 1993-05-19 1997-11-27 Vicuron Pharmaceuticals Inc. Synthetic aglucodalbaheptide antibiotics
US5684127A (en) * 1993-06-03 1997-11-04 Gruppo Lepetit Spa Tetrapeptides deriving from dalbaheptide antibiotics
DK0912604T3 (da) 1996-04-23 2002-03-25 Biosearch Italia Spa Forbedret kemisk fremgangsmåde til fremstilling af amidderivater af A 40926 antibiotikum
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
EP1095058A4 (en) * 1998-07-14 2003-07-16 Univ Princeton GLYCOPEPTIDANTIBIOTICS, COMBINATIONAL LIBRARIES OF GLYCOPEPTIDANTIBIOTICS AND METHOD FOR THEIR PRODUCTION
US6710168B1 (en) * 1999-05-19 2004-03-23 The Trustees Of The University Of Princeton Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
WO2001081373A2 (en) * 2000-04-25 2001-11-01 Merck & Co., Inc. Glycopeptide antibacterial compounds and methods of using same
ATE489962T1 (de) * 2001-04-25 2010-12-15 Wyeth Corp Im wesentlichen reine glycopeptid-antibiotika ac- 98-1; ac-98-2; ac-98-3; ac-98-4 und ac-98-5
US6713448B2 (en) * 2001-04-25 2004-03-30 Wyeth Holdings Corporation Substantially pure glycopeptide antibiotics AC-98-1; AC-98-2; AC-98-3; AC-98-4 and AC-98-5
US20040241173A1 (en) * 2002-02-14 2004-12-02 William Marsh Rice University Fullerene (C60) vancomycin conjugates as improved antibiotics
WO2005010039A1 (en) * 2003-07-31 2005-02-03 Pfizer Products Inc. Bsep polypeptide variants and uses thereof
US20070173438A1 (en) * 2006-01-13 2007-07-26 The Scripps Research Institute [PSI[CH2NH]PG4] glycopeptide antibiotic analogs
MX346043B (es) 2012-01-06 2017-03-03 Novus Int Inc Tensioactivos basados en sulfoxido.
HRP20181671T1 (hr) 2012-02-09 2018-12-14 Novus International, Inc. Heteroatom koji sadrži cikličke dimere
PL2871973T3 (pl) 2012-07-12 2019-02-28 Novus International Inc. Kompozycje matrycy i warstwy do ochrony środków bioaktywnych
CN112707851A (zh) 2015-11-12 2021-04-27 诺华丝国际股份有限公司 作为溶剂的含硫化合物
US11147249B2 (en) 2016-12-08 2021-10-19 Alector Llc Siglec transgenic mice and methods of use thereof
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
US11470827B2 (en) 2017-12-12 2022-10-18 Alector Llc Transgenic mice expressing human TREM proteins and methods of use thereof
CA3136357C (en) 2019-04-12 2023-10-17 Ecolab Usa Inc. Hard surface cleaning solution with rapid viricidal activity

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067099A (en) * 1955-09-16 1962-12-04 Lilly Co Eli Vancomycin and method for its preparation
US2990329A (en) * 1957-02-11 1961-06-27 Abbott Lab Preparation of ristocetin a salts
GB1496386A (en) * 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
US4322343A (en) * 1980-12-18 1982-03-30 Eli Lilly And Company Pseudo-aglycone of actaplanin
US4456593A (en) * 1982-06-22 1984-06-26 Abbott Laboratories Ristocetin ψ-aglycone as an antibacterial agent
US4504467A (en) * 1983-10-21 1985-03-12 Eli Lilly And Company Glycopeptide derivatives
US4497802A (en) * 1983-10-21 1985-02-05 Eli Lilly And Company N-Acyl glycopeptide derivatives
US4563442A (en) * 1983-10-21 1986-01-07 Eli Lilly And Company Glycopeptide bioconversion products
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
GB8711066D0 (en) * 1987-05-11 1987-06-17 Lepetit Spa Teicoplanin derivatives
US5438117A (en) * 1990-12-20 1995-08-01 Gruppo Lepetit S.P.A. Hexapeptides deriving from aglucoteicoplanin and a process for preparing them

Also Published As

Publication number Publication date
EP0409045B1 (en) 1997-11-19
CA2021379C (en) 2001-03-06
DE69031721D1 (de) 1998-01-02
US5648456A (en) 1997-07-15
JPH0352900A (ja) 1991-03-07
EP0409045A2 (en) 1991-01-23
IE902598A1 (en) 1991-02-27
JP2769028B2 (ja) 1998-06-25
DK0409045T3 (da) 1997-12-22
KR0145554B1 (ko) 1998-07-15
DE69031721T2 (de) 1998-03-19
EP0409045A3 (en) 1991-10-16
ATE160360T1 (de) 1997-12-15
US5602229A (en) 1997-02-11
CA2021379A1 (en) 1991-01-19
GR3025653T3 (en) 1998-03-31
KR910002898A (ko) 1991-02-26

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