ES2113338T3 - Clonado molecular y expresion de il-3 humano. - Google Patents

Clonado molecular y expresion de il-3 humano.

Info

Publication number
ES2113338T3
ES2113338T3 ES87202566T ES87202566T ES2113338T3 ES 2113338 T3 ES2113338 T3 ES 2113338T3 ES 87202566 T ES87202566 T ES 87202566T ES 87202566 T ES87202566 T ES 87202566T ES 2113338 T3 ES2113338 T3 ES 2113338T3
Authority
ES
Spain
Prior art keywords
produced
expression
human
molecular cloning
cadn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87202566T
Other languages
English (en)
Inventor
Lambertus Christiaan Dorssers
Gerard Dr Wagemaker
Yvonne Johanna Vos
Leen Robert Willem Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of ES2113338T3 publication Critical patent/ES2113338T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE HA DISPUESTO EN SISTEMAS DE EXPRESION UN CADN QUE CODIFICA LA INTERLEUCINA-3 HUMANA, DESIGNADA AQUI COMO H IL-3 O H MULTI-CSF DANDO LUGAR A QUE SE PRODUZCA HIL-3 SUSTANCIALMENTE LIBRE DE LAS IMPUREZAS QUE ACOMPAÑAN NORMALMENTE A ESTA PROTEINA, POR EJEMPLO CUANDO ES PRODUCIDA ENTRE OTRAS POR LOS LINFOCITOS DE LA SANGRE PERIFERICA. LA H IL-3 RESULTANTE PUEDE SER PRODUCIDA EN CANTIDADES IMPORTANTES Y ES UTIL PARA UNA SERIE DE FINES TERAPEUTICOS Y DE DIAGNOSTICO.
ES87202566T 1986-12-16 1987-12-16 Clonado molecular y expresion de il-3 humano. Expired - Lifetime ES2113338T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP86202285 1986-12-16
EP87201322 1987-07-13

Publications (1)

Publication Number Publication Date
ES2113338T3 true ES2113338T3 (es) 1998-05-01

Family

ID=26103432

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87202566T Expired - Lifetime ES2113338T3 (es) 1986-12-16 1987-12-16 Clonado molecular y expresion de il-3 humano.

Country Status (14)

Country Link
JP (2) JPH01502157A (es)
AT (1) ATE161882T1 (es)
AU (1) AU617095B2 (es)
CA (1) CA1341503C (es)
DE (1) DE3752158T2 (es)
ES (1) ES2113338T3 (es)
FI (1) FI102293B (es)
GR (1) GR3025857T3 (es)
IE (1) IE81129B1 (es)
IL (1) IL84852A (es)
NO (1) NO180544C (es)
NZ (1) NZ222939A (es)
PT (1) PT86381B (es)
WO (1) WO1988004691A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US6238889B1 (en) 1986-12-16 2001-05-29 Dsm N.V. Molecular cloning and expression of the Pro8 isoform of human IL-3
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
US5304637A (en) * 1987-07-13 1994-04-19 Gist-Brocades N.V. Expression and purification of human interleukin-3 and muteins thereof
GB2210883B (en) * 1987-10-08 1992-01-02 British Bio Technology Synthetic interleukin-3 gene
US6384194B1 (en) 1987-12-16 2002-05-07 Dsm N.V. Expression and purification of human interleukin-3 and muteins thereof
EP0425536A4 (en) * 1988-07-20 1992-01-02 Immunex Corporation Nonglycosylated human interleukin-3 compositions
NZ232913A (en) * 1989-03-15 1992-08-26 Gist Brocades Nv Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations
US5128450A (en) * 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
DE69030937T2 (de) 1989-08-14 1997-10-09 Gist Brocades Nv Mutanten von Interleukin-3
ATE150486T1 (de) * 1991-08-01 1997-04-15 Fond Nat Transfusion Sanguine Expression in nicht-tumorbildenden menschlichen lymphoblasten zellinien mit einem integrierenden vektor
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
EP0672145B1 (en) * 1992-11-24 2003-04-23 G.D. Searle & Co. Interleukin-3 (il-3) multiple mutation polypeptides
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
WO1999041382A2 (en) * 1998-02-17 1999-08-19 Hyseq, Inc. A novel interleukin-3 and uses thereof
WO2006079169A1 (en) * 2005-01-25 2006-08-03 Apollo Life Sciences Limited Parameter selected gm-csf, il-3, il-4, il-5 and chimeras thereof for therapeutic and diagnostic purposes
JP2009532061A (ja) * 2006-04-03 2009-09-10 ニユー・イングランド・バイオレイブス・インコーポレイテツド 組換えウシ血清アルブミン（ｒＢＳＡ）の発現、分泌及び精製、並びにその使用
IL318918A (en) 2022-08-11 2025-04-01 Universit?Tsklinikum Regensburg IL3-targeted antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695542A (en) * 1983-10-04 1987-09-22 Dnax Research Institute Of Molecular And Cellular Biology, Inc. cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
AU570762B2 (en) * 1983-12-23 1988-03-24 Australian National University, The Cloning of cdna for il-3
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors

Also Published As

Publication number Publication date
PT86381A (en) 1988-01-01
FI102293B1 (fi) 1998-11-13
GR3025857T3 (en) 1998-04-30
NO883614L (no) 1988-08-12
AU617095B2 (en) 1991-11-21
IL84852A (en) 1994-06-24
IE81129B1 (en) 2000-03-22
NO883614D0 (no) 1988-08-12
DE3752158T2 (de) 1998-05-20
IE873409L (en) 1988-06-12
DE3752158D1 (de) 1998-02-12
AU1057788A (en) 1988-07-15
FI883688A0 (fi) 1988-08-08
JPH01502157A (ja) 1989-08-03
FI102293B (fi) 1998-11-13
NO180544B (no) 1997-01-27
ATE161882T1 (de) 1998-01-15
NZ222939A (en) 1991-03-26
NO180544C (no) 1997-05-07
IL84852A0 (en) 1988-06-30
WO1988004691A1 (en) 1988-06-30
PT86381B (pt) 1990-11-20
JPH1080286A (ja) 1998-03-31
CA1341503C (en) 2006-04-04
FI883688L (fi) 1988-08-08

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