ES2114555T3 - Nuevo interferon gamma humano recombinado. - Google Patents

Nuevo interferon gamma humano recombinado.

Info

Publication number
ES2114555T3
ES2114555T3 ES92900077T ES92900077T ES2114555T3 ES 2114555 T3 ES2114555 T3 ES 2114555T3 ES 92900077 T ES92900077 T ES 92900077T ES 92900077 T ES92900077 T ES 92900077T ES 2114555 T3 ES2114555 T3 ES 2114555T3
Authority
ES
Spain
Prior art keywords
new
refers
gamma interferon
human gamma
recombined human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900077T
Other languages
English (en)
Inventor
Otto Slodowski
Joachim Bohm
Bernd Otto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung eV
Original Assignee
Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung eV filed Critical Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung eV
Application granted granted Critical
Publication of ES2114555T3 publication Critical patent/ES2114555T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO MUTANTE DEL TIPO GAMMA IFN. ESTE NUEVO POLIPEPTIDO CONTIENEN 134 AMINOACIDOS. LOS AMINOACIDOS 1 HASTA 132 SON LOS MISMOS QUE AQUELLOS DEL INTERFERON GAMMA NATURAL. EL PRIMER AMINOACIDO, METIONINA, ESTA TAMBIEN PRESENTE EN LA POSICION 0, TAL COMO HA SIDO DEMOSTRADO POR MEDIO DE SECUENCIADO DE PROTEINA. EL AMINOACIDO EN POSICION 133 ES LEUCINA EN LUGAR DE GLUTAMINA. LA INVENCION SE REFIERE TAMBIEN A LA SECUENCIA DNA Y A LA PLASMIDA DNA (DSM 6238) QUE SE CODIFICA PARA ESTE NUEVO POLIPEPTIDO. LA INVENCION SE REFIERE ADEMAS A LA UTILIZACION DEL POLIPEPTIDO COMO MEDICAMENTO ASI COMO A SU USO COMO REACTIVO QUIMICO FINO PARA EXPERIMENTOS IN VITRO.
ES92900077T 1990-11-19 1991-11-14 Nuevo interferon gamma humano recombinado. Expired - Lifetime ES2114555T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4036856A DE4036856C1 (es) 1990-11-19 1990-11-19

Publications (1)

Publication Number Publication Date
ES2114555T3 true ES2114555T3 (es) 1998-06-01

Family

ID=6418557

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900077T Expired - Lifetime ES2114555T3 (es) 1990-11-19 1991-11-14 Nuevo interferon gamma humano recombinado.

Country Status (9)

Country Link
EP (1) EP0652903B1 (es)
JP (1) JP3219274B2 (es)
AT (1) ATE163651T1 (es)
AU (1) AU9026691A (es)
CA (1) CA2096532C (es)
DE (2) DE4036856C1 (es)
DK (1) DK0652903T3 (es)
ES (1) ES2114555T3 (es)
WO (1) WO1992008737A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19535853C2 (de) * 1995-09-18 1999-04-01 Fraunhofer Ges Forschung Varianten des rekombinanten humanen Interferon-gamma, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19604583C2 (de) * 1996-02-08 1999-11-18 Fraunhofer Ges Forschung Verfahren zur Synthese von löslichen, rekombinanten Proteinen aus Bakterienzellen
JP2003513681A (ja) 1999-11-12 2003-04-15 マキシゲン・ホールディングス・リミテッド インターフェロンガンマ・コンジュゲート
US7230081B1 (en) 1999-11-12 2007-06-12 Maxygen Holdings, Ltd. Interferon gamma conjugates
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
PL366705A1 (en) * 2001-04-06 2005-02-07 Maxygen Holdings Ltd. Interferon gamma polypeptide variants
WO2004005341A2 (en) 2002-07-03 2004-01-15 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
JP7611820B2 (ja) 2018-10-11 2025-01-10 インヒブルクス バイオサイエンシズ インコーポレイテッド Ｄｌｌ３シングルドメイン抗体およびその治療用組成物
AU2019356573B2 (en) 2018-10-11 2025-12-18 Inhibrx Biosciences, Inc. PD-1 single domain antibodies and therapeutic compositions thereof
CN113166261A (zh) 2018-10-11 2021-07-23 印希比股份有限公司 B7h3单域抗体及其治疗性组合物
US12590169B2 (en) 2018-10-11 2026-03-31 Inhibrx Biosciences, Inc. 5T4 single domain antibodies and therapeutic compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
IL75302A0 (en) * 1984-06-06 1985-09-29 Takeda Chemical Industries Ltd Novel polypeptide and production thereof
JPS6124599A (ja) * 1984-07-11 1986-02-03 Kyowa Hakko Kogyo Co Ltd 新規ヒトインタ−フエロン−ｒポリペプチド誘導体
GB8619725D0 (en) * 1986-08-13 1986-09-24 Hoffmann La Roche Homogenous interferon fragments
DE3730331A1 (de) * 1987-09-10 1989-03-30 Basf Ag Neue polypeptide, verfahren zur herstellung, die vektoren dafuer und arzneimittel daraus

Also Published As

Publication number Publication date
WO1992008737A1 (de) 1992-05-29
ATE163651T1 (de) 1998-03-15
DE4036856C1 (es) 1992-05-27
CA2096532A1 (en) 1992-05-20
EP0652903A1 (de) 1995-05-17
AU9026691A (en) 1992-06-11
JP3219274B2 (ja) 2001-10-15
EP0652903B1 (de) 1998-03-04
JPH06502992A (ja) 1994-04-07
CA2096532C (en) 2002-12-31
DK0652903T3 (da) 1998-03-30
DE59108947D1 (de) 1998-04-09

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