ES2114692T3 - Reaccion en ciclos magneticos. - Google Patents

Reaccion en ciclos magneticos.

Info

Publication number
ES2114692T3
ES2114692T3 ES94920180T ES94920180T ES2114692T3 ES 2114692 T3 ES2114692 T3 ES 2114692T3 ES 94920180 T ES94920180 T ES 94920180T ES 94920180 T ES94920180 T ES 94920180T ES 2114692 T3 ES2114692 T3 ES 2114692T3
Authority
ES
Spain
Prior art keywords
reaction
amplification
nucleic acid
magnetic cycles
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94920180T
Other languages
English (en)
Inventor
Alec Mian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gamera Bioscience Corp
Original Assignee
Gamera Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamera Bioscience Corp filed Critical Gamera Bioscience Corp
Application granted granted Critical
Publication of ES2114692T3 publication Critical patent/ES2114692T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hard Magnetic Materials (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION PROPORCIONA UN PROCESO PARA LA AMPLIACION DE SECUENCIAS DE ACIDO NUCLEICO ESPECIFICAS BASADAS EN LA SEPARACION DE FILAMENTOS DE ACIDO NUCLEICO POR UN CAMPO ELECTROMAGNETICO. ESTE MEDIO DE SEPARACION PERMITE EL USO DE POLIMERASAS MESOFILICAS EN EL PROCESO DE AMPLIACION, AUMENTANDO ASI LA VELOCIDAD Y FIDELIDAD DEL PROCESO DE AMPLIACION, ASI COMO EL TAMAÑO DEL ACIDO NUCLEICO DIANA QUE PUEDE SER AMPLIADO.
ES94920180T 1993-06-09 1994-06-08 Reaccion en ciclos magneticos. Expired - Lifetime ES2114692T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7434593A 1993-06-09 1993-06-09

Publications (1)

Publication Number Publication Date
ES2114692T3 true ES2114692T3 (es) 1998-06-01

Family

ID=22119058

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94920180T Expired - Lifetime ES2114692T3 (es) 1993-06-09 1994-06-08 Reaccion en ciclos magneticos.

Country Status (12)

Country Link
US (1) US5545540A (es)
EP (1) EP0702728B1 (es)
JP (1) JPH08511425A (es)
KR (1) KR960703174A (es)
AT (1) ATE165118T1 (es)
AU (1) AU690124B2 (es)
CA (1) CA2164706C (es)
DE (1) DE69409646T2 (es)
DK (1) DK0702728T3 (es)
ES (1) ES2114692T3 (es)
GR (1) GR3026678T3 (es)
WO (1) WO1994029484A1 (es)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686271A (en) * 1994-06-09 1997-11-11 Gamera Bioscience Corporation Apparatus for performing magnetic cycle reaction
US5942391A (en) * 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US5545539A (en) * 1994-10-18 1996-08-13 Genzyme Corporation Method for nucleotide sequence amplification
US5683875A (en) * 1995-05-04 1997-11-04 Hewlett-Packard Company Method for detecting a target nucleic acid analyte in a sample
US5882867A (en) * 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US6114150A (en) * 1995-11-29 2000-09-05 Yale University Amplification of nucleic acids
US5939291A (en) * 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
WO1998004740A1 (en) * 1996-07-29 1998-02-05 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
GB9620934D0 (en) 1996-10-08 1996-11-27 Molecular Drives Limited Multi-well containers
US6057134A (en) * 1996-10-07 2000-05-02 Ambion, Inc. Modulating the efficiency of nucleic acid amplification reactions with 3' modified oligonucleotides
AU8162598A (en) * 1997-06-25 1999-01-04 Life Technologies, Inc. Improved method for isolating and recovering target dna or rna molecules having a desired nucleotide sequence
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
HUP0002356A2 (hu) * 1997-07-22 2000-11-28 Qiagen Genomics, Inc. Nukleinsav-mátrixokon lejátszódó amplifikáció és más enzimatikus reakciók
NZ501776A (en) 1997-07-22 2001-10-26 Qiagen Genomics Inc Spring probe and methods for arraying oligonucleotide and thickening agent to a solid support
US6787305B1 (en) * 1998-03-13 2004-09-07 Invitrogen Corporation Compositions and methods for enhanced synthesis of nucleic acid molecules
US6183998B1 (en) * 1998-05-29 2001-02-06 Qiagen Gmbh Max-Volmer-Strasse 4 Method for reversible modification of thermostable enzymes
CA2350882C (en) 1998-11-12 2011-02-22 Life Technologies Corporation Transfection reagents
DE19854946C2 (de) 1998-11-27 2002-01-03 Guenter Von Kiedrowski Klonieren und Kopieren an Oberflächen
AU768535B2 (en) 1998-11-30 2003-12-18 Nanosphere, Inc. Nanoparticles with polymer shells
DE19907470A1 (de) * 1999-02-12 2000-08-17 Thomas Lurz Verfahren zur Auftrennung von in Lösung befindlichen doppelsträngigen Nukleinsäuren in einzelsträngige Nukleinsäuren
DE60012562D1 (de) 1999-06-18 2004-09-02 Gamera Bioscience Corp Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US7088650B1 (en) 1999-08-23 2006-08-08 Worthington Mark O Methods and apparatus for optical disc data acquisition using physical synchronization markers
CA2396113C (en) 2000-01-13 2009-04-07 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
DE10036486A1 (de) * 2000-07-25 2002-02-14 Biotix Gmbh Verfahren zur Auftrennung von in Lösung befindlichen doppelstränigen Nukleinsäuren in einzelsträngige Nukleinsäuren
WO2002046483A2 (en) 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
US7079468B2 (en) 2000-12-08 2006-07-18 Burstein Technologies, Inc. Optical discs for measuring analytes
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
US7091034B2 (en) * 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
EP1359219A4 (en) * 2001-02-06 2004-09-22 Takara Bio Inc AMPLIFIED NUCLEIC ACIDS AND IMMOBILIZED PRODUCTS THEREOF
EP1493014A2 (en) 2001-04-11 2005-01-05 Burstein Technologies, Inc. Multi-parameter assays including analysis discs and methods relating thereto
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US9777312B2 (en) * 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
CA2466656C (en) 2001-11-09 2013-07-02 Nanosphere, Inc. Bioconjugate-nanoparticle probes
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
JP2005532456A (ja) 2002-07-02 2005-10-27 ナノスフェアー　インコーポレイテッド ナノ粒子ポリアニオン複合物ならびに分析物の検出における同複合物の用途
WO2006076022A2 (en) * 2004-05-13 2006-07-20 Anita Goel Nano-pcr: methods and devices for nucleic acid amplification and detection
MX2007013985A (es) 2005-05-09 2008-02-22 Theranos Inc Sistemas de fluidos de punto de cuidado y usos de los mismos.
AU2006287548A1 (en) * 2005-09-06 2007-03-15 Gen-Probe Incorporated Methods, compositions and kits for isothermal amplification of nucleic acids
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
JP2009534033A (ja) 2006-04-21 2009-09-24 ナノバイオシン，インコーポレイテッド 薬物発見のための単一分子プラットホーム：抗癌剤および抗ウイルス剤の発見を含む薬物発見のための方法および装置
CN104297506B (zh) 2007-10-02 2017-05-03 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
WO2012006116A2 (en) * 2010-06-28 2012-01-12 Life Technologies Corporation Methods, workflows, kits, apparatuses, and computer program media for nucleic acid sample preparation for nucleic acid sequencing
CN103477197B (zh) 2011-01-21 2016-08-17 提拉诺斯公司 样品使用最大化的系统和方法
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
JP2014530358A (ja) 2011-09-25 2014-11-17 セラノス， インコーポレイテッド 多重分析のためのシステム及び方法
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
EP2895622A4 (en) 2012-09-11 2016-05-18 Theranos Inc INFORMATION MANAGEMENT SYSTEMS AND METHODS WITH A BIOLOGICAL SIGNATURE
BR112015019315A2 (pt) 2013-02-18 2017-07-18 Theranos Inc método e sistema de avaliação de uma amostra biológica coletada de um indivíduo
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US11545241B1 (en) 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
IL274464B2 (en) 2013-12-11 2023-08-01 Accuragen Holdings Ltd Preparations and methods for the detection of rare sequence variants
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US10195280B2 (en) 2014-07-15 2019-02-05 Life Technologies Corporation Compositions and methods for efficient delivery of molecules to cells
US10125198B2 (en) 2015-04-17 2018-11-13 Distributed Bio, Inc. Method for mass humanization of non-human antibodies
CN114807323A (zh) 2015-10-09 2022-07-29 安可济控股有限公司 用于富集扩增产物的方法及组合物
EP3383994A4 (en) 2015-12-03 2019-08-28 Accuragen Holdings Limited METHOD AND COMPOSITIONS FOR FORMING LIGATION PRODUCTS
CA3024630A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
WO2018035170A1 (en) 2016-08-15 2018-02-22 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
CN112601823A (zh) 2018-06-12 2021-04-02 安可济控股有限公司 用于形成连接产物的方法和组合物
CN112654713A (zh) 2018-07-05 2021-04-13 安可济控股有限公司 用于数字聚合酶链反应的组合物和方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004470A1 (en) * 1990-09-12 1992-03-19 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
WO1992005443A1 (en) * 1990-09-15 1992-04-02 Medical Research Council Reagent separation
NZ240079A (en) * 1990-10-09 1993-07-27 Boehringer Mannheim Gmbh Method for the detection of a nucleic acid or part thereof
WO1993009250A1 (en) * 1991-11-01 1993-05-13 Adelaide Children's Hospital Solid phase amplification process
GB9201481D0 (en) * 1992-01-23 1992-03-11 Scient Generics Ltd Treatment of nucleic acid material

Also Published As

Publication number Publication date
CA2164706C (en) 2001-04-10
GR3026678T3 (en) 1998-07-31
US5545540A (en) 1996-08-13
ATE165118T1 (de) 1998-05-15
WO1994029484A1 (en) 1994-12-22
CA2164706A1 (en) 1994-12-22
DE69409646D1 (de) 1998-05-20
DK0702728T3 (da) 1998-06-02
DE69409646T2 (de) 1998-08-06
AU7106794A (en) 1995-01-03
KR960703174A (ko) 1996-06-19
JPH08511425A (ja) 1996-12-03
EP0702728A1 (en) 1996-03-27
EP0702728B1 (en) 1998-04-15
AU690124B2 (en) 1998-04-23

Similar Documents

Publication Publication Date Title
DK0702728T3 (da) Magnetisk cyklusreaktion
WO1996017959A3 (en) An apparatus for performing magnetic cycle reaction
NO950381L (no) Nukleinsyresekvens amplifikasjon
GB0127704D0 (en) Nucleic acid enrichment
ATE191934T1 (de) Verfahren zur isothermer amplifikation von nukleinsäure molekülen
ES2077887T3 (es) Amplificacion por desplazamiento de cadena.
EP0861262A4 (en) GROUPS FOR CATCHING NUCLEIC ACIDS
FI953445A0 (fi) Menetelmä nukleiinihappojen herkkään osoitukseen
IL149791A0 (en) Oligonucleotides and assemblies thereof useful in the detection of the presence or absence of target nucleic acid sequences in a sample
ATE512220T1 (de) Verfahren zur unspezifischen anreicherung von bakterienzellen
DE60228089D1 (de) Nukleinsäureamplifikation mit duplexzwischenprodukten
DK0877758T3 (da) Oprenset SR-p70-protein
DE69114844D1 (de) Enzymatisches amplifizierungsverfahren in vitro.
DE69527073D1 (de) Verfahren zur identifizierung von verbindungen, die zur behandlung von autoimmunkrankheiten verwendbar sind
DE60130465D1 (de) Mutierte muskelspezifische enhancer
WO2002031512A3 (en) Molecular interactions in hematopoietic cells
DE69637516D1 (de) Verfahren für die Amplifizierung von Nukleinsäure-Sequenzen
AU2001278551A1 (en) Method for detecting micro-organisms
TR200000150T2 (tr) Amidlerin elde edilmesine mahsus usul.
DK1180138T3 (da) Polynukleotidmotor, motorsystem, fremstilling og anvendelse deraf
ATE307201T1 (de) Srcr domäne-enthaltendes protein
AU1911395A (en) Method, reagent and kit for the detection and amplification of nucleic acid sequences
WO2003104478A3 (en) Detection of rna structural elements
UA31082A (uk) Спосіб прискорення біологічного дослідження на туберкульоз
MY110525A (en) Strand displacement amplification

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 702728

Country of ref document: ES