ES2114946T3 - Derivado de acido metanodifosfonico, su produccion y uso medicinal. - Google Patents

Derivado de acido metanodifosfonico, su produccion y uso medicinal.

Info

Publication number
ES2114946T3
ES2114946T3 ES92918702T ES92918702T ES2114946T3 ES 2114946 T3 ES2114946 T3 ES 2114946T3 ES 92918702 T ES92918702 T ES 92918702T ES 92918702 T ES92918702 T ES 92918702T ES 2114946 T3 ES2114946 T3 ES 2114946T3
Authority
ES
Spain
Prior art keywords
alkyl
medicinal use
methanodiphosphonic
derivative
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92918702T
Other languages
English (en)
Inventor
Norio Kawabe
Hiromi Uchiro
Teruo Nakadate
Masahiko Tanahashi
Masatoshi Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of ES2114946T3 publication Critical patent/ES2114946T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UN DERIVADO DE ACIDO METANODIFOSFONICO REPRESENTADO POR LA FORMULA (I) O (II), UN PROCESO PARA PRODUCIR EL MISMO, Y UN USO MEDICO DE ESTE, DONDE B REPRESENTA HIDROGENO, ALQUILO, HIDROXI, ALCOXIO AMINO; D REPRESENTA AZUFRE, OXIGENO, NH, NITROGENO SUSTITUIDO POR ALQUILO, CH2 O SCH2; X REPRESENTA ALQUILO QUE PUEDE ESTAR SUSTITUIDO POR UN HETEROATOMO, ARILO O ACILO; M REPRESENTA UN NUMERO ENTERO DE 1 A 5; Y R1, R2, R3 Y R4 REPRESENTAN CADA UNO INDEPENDIENTEMENTE HIDROGENO, ALQUILO C1-C4 O UN CATION FARMACEUTICAMENTE ACEPTABLE. EL COMPUESTO ES EXCELENTE EN ACTIVIDAD ANTIOXIDANTE, DE INHIBICION DE IL, E INHIBICION DE RESORCION Y UTIL PARA TRATAR LA INFLAMACION. EL REUMATISMO, TRASTORNOS DEL METABOLISMO DE HUESOS, ENFERMEDADES AUTOINMUNES, ETC.
ES92918702T 1991-09-05 1992-09-07 Derivado de acido metanodifosfonico, su produccion y uso medicinal. Expired - Lifetime ES2114946T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22617591 1991-09-05
JP17980292 1992-07-07

Publications (1)

Publication Number Publication Date
ES2114946T3 true ES2114946T3 (es) 1998-06-16

Family

ID=26499539

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92918702T Expired - Lifetime ES2114946T3 (es) 1991-09-05 1992-09-07 Derivado de acido metanodifosfonico, su produccion y uso medicinal.

Country Status (9)

Country Link
US (2) US5527940A (es)
EP (1) EP0594857B1 (es)
JP (1) JPH0826048B2 (es)
AT (1) ATE165603T1 (es)
CA (1) CA2095128C (es)
DE (1) DE69225325T2 (es)
DK (1) DK0594857T3 (es)
ES (1) ES2114946T3 (es)
WO (1) WO1993005052A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0642519T3 (da) * 1992-05-29 2000-09-18 Procter & Gamble Pharma Svovlholdige phosphonatforbindelser til behandling af unormal calcium- og phosphatmetabolisme
JPH06135976A (ja) * 1992-10-30 1994-05-17 Toray Ind Inc メタンジホスホン酸誘導体、その製造方法およびその医薬用途
DE69529975T2 (de) * 1994-12-22 2004-01-08 Toray Industries, Inc. Verfahren zur herstellung von bis(4-alkylthiophenyl)disulfid
EP0998934A4 (en) * 1997-12-25 2005-09-14 Toray Industries REMEDIES AGAINST INTRAMEDULLARY DISEASES
DE19828450A1 (de) * 1998-06-26 1999-12-30 Hassan Jomaa Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien
EP1057488A4 (en) * 1998-12-25 2003-10-22 Toray Industries INTERLEUKIN-6 PRODUCTION INHIBITORS
ES2337545T3 (es) * 1999-07-19 2010-04-27 Toray Industries, Inc. Farmacos para enfermedades periodontales.
US6692758B1 (en) * 1999-08-02 2004-02-17 Toray Industries, Inc. Insertion stabilizers for implants
JP2001181191A (ja) * 1999-12-24 2001-07-03 Cci Corp 慢性関節リウマチ疾患予防および治療剤
US6548042B2 (en) 2000-08-07 2003-04-15 Arstad Erik Bis-phosphonate compounds
US20060040899A1 (en) * 2000-12-15 2006-02-23 Hassan Jomaa Medicaments containing bisphosphonic acids and derivatives thereof for preventing and treating diseases and allergies
EP1506208A4 (en) * 2002-05-11 2006-05-24 Ilex Products Inc 1,1- AND 1,2-BISPHOSPHONATES AS MODULATORS OF APOLIPOPROTEIN E
EP2340841B1 (en) * 2008-09-03 2016-11-09 Tohoku University Osteogenesis promoter comprising [4-(methylthio)phenylthio]methanebisphosphonic acid or pharmaceutically acceptable salt thereof as active ingredient
JP7076798B2 (ja) * 2015-09-09 2022-05-30 清華大学 効果的なワクチンアジュバントとするメバロン酸経路の阻害剤
JP2024169831A (ja) * 2023-05-26 2024-12-06 公立大学法人福島県立医科大学 抗酸化剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3609075A (en) * 1968-06-25 1971-09-28 Procter & Gamble Cleaning and softening detergent compositions
DE3365492D1 (en) * 1982-01-27 1986-10-02 Schering Ag Diphosphonic acid derivatives and pharmaceutical preparations containing them
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
CH675422A5 (es) * 1988-03-31 1990-09-28 Symphar Sa
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
DE69023844T2 (de) * 1989-09-06 1996-06-20 Merck & Co Inc Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
US5256808A (en) * 1992-12-04 1993-10-26 The University Of Tennessee Research Corp. Synthesis of tetraalkyl vinylidene diphosphonate monomer

Also Published As

Publication number Publication date
DK0594857T3 (da) 1998-10-07
DE69225325D1 (de) 1998-06-04
US5683992A (en) 1997-11-04
EP0594857A4 (en) 1994-05-18
WO1993005052A1 (en) 1993-03-18
JPH06500489A (ja) 1994-01-20
CA2095128A1 (en) 1993-03-06
JPH0826048B2 (ja) 1996-03-13
EP0594857B1 (en) 1998-04-29
DE69225325T2 (de) 1998-08-27
EP0594857A1 (en) 1994-05-04
US5527940A (en) 1996-06-18
ATE165603T1 (de) 1998-05-15
CA2095128C (en) 1998-01-06

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