ATE165603T1 - Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel - Google Patents

Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel

Info

Publication number
ATE165603T1
ATE165603T1 AT92918702T AT92918702T ATE165603T1 AT E165603 T1 ATE165603 T1 AT E165603T1 AT 92918702 T AT92918702 T AT 92918702T AT 92918702 T AT92918702 T AT 92918702T AT E165603 T1 ATE165603 T1 AT E165603T1
Authority
AT
Austria
Prior art keywords
alkyl
acid derivative
methandiphosphoic
production
medicinal product
Prior art date
Application number
AT92918702T
Other languages
English (en)
Inventor
Norio Kawabe
Hiromi Uchiro
Teruo Nakadate
Masahiko Tanahashi
Masatoshi Ito
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE165603T1 publication Critical patent/ATE165603T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT92918702T 1991-09-05 1992-09-07 Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel ATE165603T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22617591 1991-09-05
JP17980292 1992-07-07

Publications (1)

Publication Number Publication Date
ATE165603T1 true ATE165603T1 (de) 1998-05-15

Family

ID=26499539

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92918702T ATE165603T1 (de) 1991-09-05 1992-09-07 Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel

Country Status (9)

Country Link
US (2) US5527940A (de)
EP (1) EP0594857B1 (de)
JP (1) JPH0826048B2 (de)
AT (1) ATE165603T1 (de)
CA (1) CA2095128C (de)
DE (1) DE69225325T2 (de)
DK (1) DK0594857T3 (de)
ES (1) ES2114946T3 (de)
WO (1) WO1993005052A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69329199D1 (de) * 1992-05-29 2000-09-14 Procter & Gamble Pharma Schwefel-enthaltende phosphonat-verbindungen zur behandlung von abnormalem calzium- und phosphat- metabolismus
JPH06135976A (ja) * 1992-10-30 1994-05-17 Toray Ind Inc メタンジホスホン酸誘導体、その製造方法およびその医薬用途
JP3626500B2 (ja) * 1994-12-22 2005-03-09 東レ株式会社 「ビス（４−アルキルチオフェニル）ジスルフィドの製造法」
EP0998934A4 (de) * 1997-12-25 2005-09-14 Toray Industries Heilmittel gegen intramedullare krankheiten
DE19828450A1 (de) * 1998-06-26 1999-12-30 Hassan Jomaa Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien
EP1057488A4 (de) * 1998-12-25 2003-10-22 Toray Industries Inhibitoren der interleukin-6 produktion
EP1114642B1 (de) * 1999-07-19 2010-01-06 Toray Industries, Inc. Medikamente zur behandlung von periodontalen erkrankungen
EP1118328A1 (de) * 1999-08-02 2001-07-25 Toray Industries, Inc. Einfügungsstabilisatoren für implantate
JP2001181191A (ja) * 1999-12-24 2001-07-03 Cci Corp 慢性関節リウマチ疾患予防および治療剤
US6548042B2 (en) 2000-08-07 2003-04-15 Arstad Erik Bis-phosphonate compounds
US20060040899A1 (en) * 2000-12-15 2006-02-23 Hassan Jomaa Medicaments containing bisphosphonic acids and derivatives thereof for preventing and treating diseases and allergies
WO2003094851A2 (en) * 2002-05-11 2003-11-20 Ilex Products, Inc. 1,1- and 1,2-bisphosphonates as apoliprotein e modulators
JP5655179B2 (ja) * 2008-09-03 2015-01-21 国立大学法人東北大学 ［４−（メチルチオ）フェニルチオ］メタンビスホスホン酸又は薬学的に許容され得るその塩を有効成分とする骨形成促進剤
KR102116528B1 (ko) * 2015-09-09 2020-05-28 칭화 유니버시티 고-효율 백신 아쥬반트로서 메발로네이트 경로 억제제
JP2024169831A (ja) * 2023-05-26 2024-12-06 公立大学法人福島県立医科大学 抗酸化剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3609075A (en) * 1968-06-25 1971-09-28 Procter & Gamble Cleaning and softening detergent compositions
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
EP0243173B1 (de) * 1986-04-24 1991-06-26 Fujisawa Pharmaceutical Co., Ltd. Diphosphonsäure-Verbindungen, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel
CH675422A5 (de) * 1988-03-31 1990-09-28 Symphar Sa
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
EP0416689B1 (de) * 1989-09-06 1995-11-29 Merck & Co. Inc. Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
US5256808A (en) * 1992-12-04 1993-10-26 The University Of Tennessee Research Corp. Synthesis of tetraalkyl vinylidene diphosphonate monomer

Also Published As

Publication number Publication date
JPH06500489A (ja) 1994-01-20
JPH0826048B2 (ja) 1996-03-13
WO1993005052A1 (en) 1993-03-18
EP0594857A4 (en) 1994-05-18
US5527940A (en) 1996-06-18
EP0594857B1 (de) 1998-04-29
DE69225325D1 (de) 1998-06-04
EP0594857A1 (de) 1994-05-04
US5683992A (en) 1997-11-04
ES2114946T3 (es) 1998-06-16
DE69225325T2 (de) 1998-08-27
CA2095128C (en) 1998-01-06
CA2095128A1 (en) 1993-03-06
DK0594857T3 (da) 1998-10-07

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee