ES2118084T3 - Anticuerpos anti-icam-1 quimericos humanizados, metodos de preparacion y su uso. - Google Patents

Anticuerpos anti-icam-1 quimericos humanizados, metodos de preparacion y su uso.

Info

Publication number
ES2118084T3
ES2118084T3 ES91909612T ES91909612T ES2118084T3 ES 2118084 T3 ES2118084 T3 ES 2118084T3 ES 91909612 T ES91909612 T ES 91909612T ES 91909612 T ES91909612 T ES 91909612T ES 2118084 T3 ES2118084 T3 ES 2118084T3
Authority
ES
Spain
Prior art keywords
antibodies
icam
humanized
humanized anti
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91909612T
Other languages
English (en)
Inventor
John Robert George Road Adair
Martyn Kim Robinson
Susan Margaret Bright
Robert A Rothlein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celltech R&D Ltd
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Celltech Therapeutics Ltd
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Therapeutics Ltd, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Celltech Therapeutics Ltd
Application granted granted Critical
Publication of ES2118084T3 publication Critical patent/ES2118084T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION PRESENTA ANTICUERPOS QUIMERICOS HUMANIZADOS QUE SON CAPACES DE UNIRSE A LA MOLECULA ICAM-1 DE ADHESION INTRACELULAR. ESPECIFICAMENTE, SE PRESENTA ANTICUERPOS ANTI-ICAM-1 HUMANIZADOS DEL SUBTIPO IGG1, IGG2 E IGG4. ESTOS ANTICUERPOS SON UTILES EN EL TRATAMIENTO DE INFLAMACIONES ESPECIFICAS Y NO ESPECIFICAS, INFECCIONES VIRALES, INFECCIONES POR EL HIV, LA DISEMINACION DE CELULAS INFECTADAS POR EL HIV, Y ASMA. ADEMAS, LOS ANTICUERPOS HUMANIZADOS DESCUBIERTOS PUEDEN SER UTILES EN METODOS DE DIAGNOSIS Y LUGARES DE LOCALIZACION DE INFLAMACIONES E INFECCIONES Y TUMORES QUE EXPRESAN ICAM-1.
ES91909612T 1990-04-27 1991-04-29 Anticuerpos anti-icam-1 quimericos humanizados, metodos de preparacion y su uso. Expired - Lifetime ES2118084T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909009548A GB9009548D0 (en) 1990-04-27 1990-04-27 Chimeric antibody and method

Publications (1)

Publication Number Publication Date
ES2118084T3 true ES2118084T3 (es) 1998-09-16

Family

ID=10675133

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91909612T Expired - Lifetime ES2118084T3 (es) 1990-04-27 1991-04-29 Anticuerpos anti-icam-1 quimericos humanizados, metodos de preparacion y su uso.

Country Status (14)

Country Link
EP (1) EP0528931B1 (es)
JP (1) JPH05507406A (es)
AT (1) ATE168013T1 (es)
AU (1) AU649682B2 (es)
BR (1) BR9106394A (es)
CA (1) CA2081479A1 (es)
DE (1) DE69129743T2 (es)
DK (1) DK0528931T3 (es)
ES (1) ES2118084T3 (es)
FI (1) FI924819A0 (es)
GB (1) GB9009548D0 (es)
HU (1) HUT66103A (es)
NO (2) NO924088L (es)
WO (1) WO1991016928A1 (es)

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US5700658A (en) * 1992-01-27 1997-12-23 Icos Corporation ICAM-4 materials and methods
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
US5753502A (en) * 1993-08-05 1998-05-19 Icos Corporation Neuron-specific ICAM-4 promoter
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US5852170A (en) * 1992-01-27 1998-12-22 Icos Corporation ICAM-4 materials and methods
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US5773218A (en) * 1992-01-27 1998-06-30 Icos Corporation Method to identify compounds which modulate ICAM-related protein interactions
US5773293A (en) * 1992-01-27 1998-06-30 Icos Corporation Anti-ICAM-4 antibodies and hybridomas
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US7531643B2 (en) 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
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CA2339487C (en) * 1998-08-04 2011-05-24 The Trustees Of The University Of Pennsylvania Targeting and prolonging association of drugs to the luminal surface of the pulmonary vascular endothelial cells
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
US6670321B1 (en) 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
US7696325B2 (en) 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
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Also Published As

Publication number Publication date
HUT66103A (en) 1994-09-28
WO1991016928A1 (en) 1991-11-14
FI924819A7 (fi) 1992-10-23
FI924819L (fi) 1992-10-23
EP0528931A4 (en) 1993-04-28
ATE168013T1 (de) 1998-07-15
DE69129743T2 (de) 1999-02-11
FI924819A0 (fi) 1992-10-23
BR9106394A (pt) 1993-04-27
AU649682B2 (en) 1994-06-02
NO984136D0 (no) 1998-09-08
JPH05507406A (ja) 1993-10-28
EP0528931B1 (en) 1998-07-08
NO924088L (no) 1992-12-23
EP0528931A1 (en) 1993-03-03
DE69129743D1 (de) 1998-08-13
AU7860391A (en) 1991-11-27
NO984136L (no) 1992-12-23
NO924088D0 (no) 1992-10-22
HU9203370D0 (en) 1993-01-28
CA2081479A1 (en) 1991-10-28
GB9009548D0 (en) 1990-06-20
DK0528931T3 (da) 1999-04-19

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