ES2118357T3 - Empleo de gamma-hidroxibutirato de acil l-carnitina para el tratamiento de alcoholismo. - Google Patents

Empleo de gamma-hidroxibutirato de acil l-carnitina para el tratamiento de alcoholismo.

Info

Publication number
ES2118357T3
ES2118357T3 ES94830122T ES94830122T ES2118357T3 ES 2118357 T3 ES2118357 T3 ES 2118357T3 ES 94830122 T ES94830122 T ES 94830122T ES 94830122 T ES94830122 T ES 94830122T ES 2118357 T3 ES2118357 T3 ES 2118357T3
Authority
ES
Spain
Prior art keywords
acil
carnitine
alcoholism
hydroxybutyrate
gamma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94830122T
Other languages
English (en)
Inventor
Giovanni Scapagnini
Claudio Cavazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2118357T3 publication Critical patent/ES2118357T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

SE PRESENTA EL USO DE ESTERES DE L-CARNITINA CON ACIDO GAMMAHIDROXIBUTIRICO DE LA FORMULA I EN LA QUE R ES UN ACIL RECTO O RAMIFICADO CON ENTRE 2 Y 5 ATOMOS DE CARBONO, PREFERIBLEMENTE ACETILO, PROPIONILO, N-BUTIRILO, ISOBUTIRILO E ISOVALERILO, Y X ES UN ANION DE UN ACIDO FARMACOLOGICAMENTE ACEPTABLE PARA LAS SALES INTERNAS CORRESPONDIENTES PARA PRODUCIR UNA DROGA PARA SUPRIMIR LOS SINTOMAS DE ABSTINENCIA DEL ALCOHOL EN LOS ALCOHOLICOS.
ES94830122T 1993-03-26 1994-03-21 Empleo de gamma-hidroxibutirato de acil l-carnitina para el tratamiento de alcoholismo. Expired - Lifetime ES2118357T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930191A IT1261432B (it) 1993-03-26 1993-03-26 Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.

Publications (1)

Publication Number Publication Date
ES2118357T3 true ES2118357T3 (es) 1998-09-16

Family

ID=11401655

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94830122T Expired - Lifetime ES2118357T3 (es) 1993-03-26 1994-03-21 Empleo de gamma-hidroxibutirato de acil l-carnitina para el tratamiento de alcoholismo.

Country Status (7)

Country Link
EP (1) EP0616805B1 (es)
JP (1) JPH06321875A (es)
AT (1) ATE167056T1 (es)
DE (1) DE69410866T2 (es)
DK (1) DK0616805T3 (es)
ES (1) ES2118357T3 (es)
IT (1) IT1261432B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9708147A (es) * 1995-04-21 1997-12-31 Neurosearch As Compuestos de bencimidazol y su uso como moduladores del complejo receptor de gabaa.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1217783B (it) * 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie

Also Published As

Publication number Publication date
ITRM930191A1 (it) 1994-09-26
HK1009326A1 (en) 1999-05-28
EP0616805A1 (en) 1994-09-28
IT1261432B (it) 1996-05-23
DE69410866T2 (de) 1998-10-15
ITRM930191A0 (it) 1993-03-26
ATE167056T1 (de) 1998-06-15
DK0616805T3 (da) 1999-02-01
DE69410866D1 (de) 1998-07-16
JPH06321875A (ja) 1994-11-22
EP0616805B1 (en) 1998-06-10

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