ES2120686T3 - Derivados de bacatin y procedimientos para prepararlos. - Google Patents

Derivados de bacatin y procedimientos para prepararlos.

Info

Publication number
ES2120686T3
ES2120686T3 ES95308220T ES95308220T ES2120686T3 ES 2120686 T3 ES2120686 T3 ES 2120686T3 ES 95308220 T ES95308220 T ES 95308220T ES 95308220 T ES95308220 T ES 95308220T ES 2120686 T3 ES2120686 T3 ES 2120686T3
Authority
ES
Spain
Prior art keywords
group
substituted
unsubstituted
residue
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95308220T
Other languages
English (en)
Inventor
Kenji Tsujihari
Tomiki Hashiyama
Motoaki Ohashi
Noriyuki Nakanishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26540092&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2120686(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2120686T3 publication Critical patent/ES2120686T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTA UN COMPUESTO REPRESENTADO POR LA FORMULA (I) EN DONDE R3 REPRESENTA UN GRUPO DE ALCANOILO INFERIOR; R4 REPRESENTA UN GRUPO DE BENZOILO SUSTITUIDO O INSUSTITUIDO; EL ANILLO A REPRESENTA UN ANILLO DE CICLOPROPANO SUSTITUIDO O INSUSTITUIDO; X REPRESENTA UN ENLACE SIMPLE O UN GRUPO REPRESENTADO POR -O-, S- O -NH-; R REPRESENTA UN GRUPO DE ALQUILO INFERIOR SUSTITUIDO O INSUSTITUIDO EN DONDE EL GRUPO DE ALQUILO INFERIOR PUEDE TENER UNIDA UNA MOLECULA DE CICLOALQUILO; UN GRUPO DE ARILO SUSTITUIDO O INSUSTITUIDO O UN GRUPO HETEROCICLICO AROMATICO SUSTITUIDO O INSUSTITUIDO; E REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO REPRESENTADO POR -CO(CH{SUB,2}){SUB,N}ZY; Y REPRESENTA UN RESIDUO OBTENIDO A PARTIR DE UN AMINOACIDO O UN DIPEPTIDO MEDIANTE LA ELIMINACION DEL GRUPO DE HIDROXIL DE UN GRUPO DE CARBOXILO, EN DONDE EL GRUPO DE AMINO EXISTENTE EN DICHO RESIDUO PUEDE ESTAR PROTEGIDO, Y EL GRUPO DE CARBOXILO EN DICHO RESIDUO PUEDE ESTAR ESTERIFICADO O AMIDATADO; Z REPRESENTA UN GRUPO REPRESENTADO POR LA FORMULA -O- O -NH_; Y N REPRESENTA 1, 2, 3, 4, 5 O 6, TAMBIEN SE PRESENTAN LAS SALES FARMACOLOGICAMENTE ACEPTABLES DEL COMPUESTO QUE PRESENTAN UNA EXCELENTE ACTIVIDAD ANTITUMORAL Y POR LO TANTO SON UTILES EN LA PROFILAXIS DE UNA CIERTA GAMA DE TUMORES, TALES COMO EL CANCER DE PECHO, EL CANCER DE OVARIO, EL CANCER DE PULMON Y EL MELANOMA MALIGNO.
ES95308220T 1994-11-17 1995-11-16 Derivados de bacatin y procedimientos para prepararlos. Expired - Lifetime ES2120686T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28378094 1994-11-17
JP25118595 1995-09-28

Publications (1)

Publication Number Publication Date
ES2120686T3 true ES2120686T3 (es) 1998-11-01

Family

ID=26540092

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95308220T Expired - Lifetime ES2120686T3 (es) 1994-11-17 1995-11-16 Derivados de bacatin y procedimientos para prepararlos.

Country Status (9)

Country Link
US (2) US5589502A (es)
EP (1) EP0712854B1 (es)
KR (1) KR960017653A (es)
CN (1) CN1129217A (es)
AT (1) ATE167860T1 (es)
CA (1) CA2162759A1 (es)
DE (1) DE69503213T2 (es)
DK (1) DK0712854T3 (es)
ES (1) ES2120686T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335362B1 (en) * 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
EP1019347B1 (en) * 1997-08-21 2003-03-19 Florida State University Method for the synthesis of taxanes
PL350028A1 (en) 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
JP2004525860A (ja) 2000-09-22 2004-08-26 ブリストル−マイヤーズ スクイブ カンパニー 併用化学療法剤の毒性を低下させる方法
CA2354478A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6013776A (ja) * 1983-07-05 1985-01-24 Sawai Seiyaku Kk 光学活性３−（ｐ−アルコキシフエニル）グリシツド酸誘導体の製造法
JPS6013775A (ja) * 1983-07-05 1985-01-24 Sawai Seiyaku Kk 光学活性３−（ｐ−アルコキシフエニル）グリシツド酸アルカリ金属塩の製造法
US4825688A (en) * 1987-07-02 1989-05-02 Kraus Jr Robert P Apparatus for sensing of mass in baths
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
JPH0678B2 (ja) * 1988-09-02 1994-01-05 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
HU226369B1 (en) * 1991-09-23 2008-09-29 Univ Florida State Process for preparing substituted isoserine-esters using metal alkoxides and beta-lactams
WO1993010076A1 (en) * 1991-11-22 1993-05-27 The University Of Mississippi Synthesis and optical resolution of the taxol side chain and related compounds
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
WO1993021173A1 (en) * 1992-04-17 1993-10-28 Abbott Laboratories Taxol derivatives
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
JPH064607A (ja) * 1992-06-18 1994-01-14 Ricoh Co Ltd データ表示装置
GB9213077D0 (en) * 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
JPH0651689A (ja) * 1992-07-27 1994-02-25 Meiji Toshiyo Shuppan Kk 学習テキスト対応コンピュータ・ソフト
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
EP0667772B9 (en) * 1992-11-13 2004-08-04 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
HU0203995D0 (en) * 1992-12-23 2003-04-28 Bristol Myers Squibb Co Oxazole derivatives for synthesis of sidechain-bearing taxanes and preparation thereof
NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State C10 taxane derivatives and pharmaceutical compositions containing them
JP3431155B2 (ja) * 1993-01-15 2003-07-28 フロリダ・ステート・ユニバーシティー １０−デスアセトキシバッカチンｉｉｉの製法
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
WO1994018186A1 (en) * 1993-02-05 1994-08-18 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable a-ring side chains
DE69432140T2 (de) * 1993-03-05 2003-07-31 Florida State University, Tallahassee Verfahren zur Herstellung von 9-Desoxotaxanen
EP0688212B1 (en) * 1993-03-05 2002-06-12 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
DK1227093T3 (da) * 1993-03-22 2005-08-29 Univ Florida State Beta-lactamer, der kan anvendes til fremstilling af taxaner med en furyl- eller thienylsubstitueret sidekæde
ATE195421T1 (de) * 1993-03-22 2000-09-15 Univ Florida State Taxane mit amino-substituierter seitenkette
US6214345B1 (en) * 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
IL109926A (en) * 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
WO1995004154A1 (en) * 1993-07-27 1995-02-09 Nippon Steel Corporation Process for producing taxol and its analogues using microorganisms
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
FR2711370B1 (fr) * 1993-10-18 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2712288B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
US5395850A (en) * 1994-03-10 1995-03-07 Bristol-Myers Squibb Company 6,7-epoxy paclitaxels
GB9405400D0 (en) * 1994-03-18 1994-05-04 Erba Carlo Spa Taxane derivatives
JP3015398U (ja) 1995-03-04 1995-08-29 西岡 璋 内燃機関等の排ガス浄化燃料節減装置

Also Published As

Publication number Publication date
DE69503213T2 (de) 1998-10-22
ATE167860T1 (de) 1998-07-15
KR960017653A (ko) 1996-06-17
EP0712854B1 (en) 1998-07-01
US5608073A (en) 1997-03-04
EP0712854A1 (en) 1996-05-22
CN1129217A (zh) 1996-08-21
DE69503213D1 (de) 1998-08-06
US5589502A (en) 1996-12-31
CA2162759A1 (en) 1996-05-18
DK0712854T3 (da) 1998-11-16

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