ES2122246T3 - Sevoflurano deuterado como anestesico de inhalacion. - Google Patents

Sevoflurano deuterado como anestesico de inhalacion.

Info

Publication number
ES2122246T3
ES2122246T3 ES94909511T ES94909511T ES2122246T3 ES 2122246 T3 ES2122246 T3 ES 2122246T3 ES 94909511 T ES94909511 T ES 94909511T ES 94909511 T ES94909511 T ES 94909511T ES 2122246 T3 ES2122246 T3 ES 2122246T3
Authority
ES
Spain
Prior art keywords
sevoflurane
deuterated
inhalation anesthetic
sub
anesthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909511T
Other languages
English (en)
Inventor
John H Tinker
Max T Baker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Iowa Research Foundation UIRF
Original Assignee
University of Iowa Research Foundation UIRF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/076,582 external-priority patent/US5391579A/en
Priority claimed from US08/079,165 external-priority patent/US5492111A/en
Application filed by University of Iowa Research Foundation UIRF filed Critical University of Iowa Research Foundation UIRF
Application granted granted Critical
Publication of ES2122246T3 publication Critical patent/ES2122246T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EN UN ASPECTO LA INVENCION SE REFIERE A LA PREPARACION DE SEVOFLURANO DEUTERIZADO Y A SU USO COMO ANESTESICO POR INHALACION. EN UN ASPECTO ADICIONAL LA INVENCION SE REFIERE A LA MINIMIZACION DE LA DEGRADACION DEL SEVOFLURANO EN F{SUB,2}C==C(CF{SUB,3}OCH{SUB,2}F (COMPUESTO A) EN DEPURADORES DE DIOXIDO DE CARBONO POR MEDIO DE EL ENFRIAMIENTO DE LOS DEPURADORES.
ES94909511T 1993-01-28 1994-01-25 Sevoflurano deuterado como anestesico de inhalacion. Expired - Lifetime ES2122246T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1026493A 1993-01-28 1993-01-28
US08/076,582 US5391579A (en) 1993-01-28 1993-06-14 Deuterated sevoflurane as an inhalational anesthetic
US08/079,165 US5492111A (en) 1993-01-28 1993-08-12 Method of elimination of volatile degradation products of sevoflurane during anesthesia

Publications (1)

Publication Number Publication Date
ES2122246T3 true ES2122246T3 (es) 1998-12-16

Family

ID=27359193

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909511T Expired - Lifetime ES2122246T3 (es) 1993-01-28 1994-01-25 Sevoflurano deuterado como anestesico de inhalacion.

Country Status (8)

Country Link
EP (1) EP0682649B1 (es)
JP (1) JPH08509206A (es)
AT (1) ATE170506T1 (es)
AU (1) AU6233494A (es)
CA (1) CA2155002A1 (es)
DE (1) DE69413005T2 (es)
ES (1) ES2122246T3 (es)
WO (1) WO1994017016A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10129832A1 (de) * 2001-06-17 2003-07-10 Berolina Drug Dev Ab Svedala Deuterierte N- und alpha-substituierte Diphenylalkoxyessigsäureaminoalkylester sowie diese Verbindungen enthaltende Arzneimittel
CN107226769A (zh) * 2017-06-19 2017-10-03 郑州泰基鸿诺医药股份有限公司 一种含二氟氘代甲氧（硫）基官能团的芳香类化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683092A (en) 1970-07-31 1972-08-08 Baxter Laboratories Inc Method of anesthesia
US4153636A (en) * 1977-01-17 1979-05-08 The Dow Chemical Company Deuterated analogues of methoxyflurane useful as an anesthetic
US4154971A (en) * 1977-06-06 1979-05-15 The Dow Chemical Company Deuterated 1,1-difluoro-2,2-dihaloethyl difluoromethyl ethers
US4220664A (en) * 1979-01-29 1980-09-02 The Dow Chemical Company Deuterated isoflurane as an anesthetic agent

Also Published As

Publication number Publication date
EP0682649B1 (en) 1998-09-02
WO1994017016A1 (en) 1994-08-04
DE69413005D1 (de) 1998-10-08
DE69413005T2 (de) 1999-05-06
ATE170506T1 (de) 1998-09-15
EP0682649A1 (en) 1995-11-22
JPH08509206A (ja) 1996-10-01
CA2155002A1 (en) 1994-08-04
AU6233494A (en) 1994-08-15

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