ES2125361T3 - Uso de 5-amino-ftaloilhidrazida como agente anti-hipoxico y de defensa. - Google Patents

Uso de 5-amino-ftaloilhidrazida como agente anti-hipoxico y de defensa.

Info

Publication number
ES2125361T3
ES2125361T3 ES94102182T ES94102182T ES2125361T3 ES 2125361 T3 ES2125361 T3 ES 2125361T3 ES 94102182 T ES94102182 T ES 94102182T ES 94102182 T ES94102182 T ES 94102182T ES 2125361 T3 ES2125361 T3 ES 2125361T3
Authority
ES
Spain
Prior art keywords
hypoxic
ftaloilhidrazida
amino
defense agent
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94102182T
Other languages
English (en)
Inventor
Lonid Minin
Slava Saizev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MEDINKOR ZMM AG
Original Assignee
MEDINKOR ZMM AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MEDINKOR ZMM AG filed Critical MEDINKOR ZMM AG
Application granted granted Critical
Publication of ES2125361T3 publication Critical patent/ES2125361T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paints Or Removers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE AL USO DE DERIVADOS DE FTALOILHIDRAZIDAS Y DE SUS SALES COMO AGENTES ANTI-HIPOXICOS Y DEFENSIVOS, CENTRANDOSE ESPECIALMENTE EN EL USO DE 5-AMINOFTALOILHIDRAZIDAS Y SUS SALES CUANDO SE ADMINISTRAN EN DOSIS ELEVADAS.
ES94102182T 1993-02-19 1994-02-12 Uso de 5-amino-ftaloilhidrazida como agente anti-hipoxico y de defensa. Expired - Lifetime ES2125361T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH531/93A CH683966A5 (it) 1993-02-19 1993-02-19 Composti della classe dei ftalidrazidici come sostanze attive in agenti anti-ipossici e di difesa.

Publications (1)

Publication Number Publication Date
ES2125361T3 true ES2125361T3 (es) 1999-03-01

Family

ID=4189148

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94102182T Expired - Lifetime ES2125361T3 (es) 1993-02-19 1994-02-12 Uso de 5-amino-ftaloilhidrazida como agente anti-hipoxico y de defensa.

Country Status (7)

Country Link
US (1) US5512573A (es)
EP (1) EP0612733B1 (es)
JP (1) JP2725994B2 (es)
AT (1) ATE170847T1 (es)
CH (1) CH683966A5 (es)
DE (1) DE69413090T2 (es)
ES (1) ES2125361T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
US6489326B1 (en) 2000-03-28 2002-12-03 Anatoliy Ivanovich Pavlov Medicinal preparation and process for manufacturing thereof
RU2211036C2 (ru) * 2001-11-20 2003-08-27 Общество с ограниченной ответственностью "Абидофарма" Лекарственный препарат (варианты) и способ его производства
US6953799B1 (en) * 2002-10-30 2005-10-11 Bach Pharma, Inc. Modulation of cell fates and activities by diketo phthalazines
US7326690B2 (en) 2002-10-30 2008-02-05 Bach Pharma, Inc. Modulation of cell fates and activities by phthalazinediones
RU2302863C2 (ru) * 2003-04-18 2007-07-20 Общество с ограниченной ответственностью "Абидофарма" Лекарственный препарат (варианты)
EP1655301B1 (en) * 2003-08-04 2015-03-11 Valery Khazhmuratovich Zhilov Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon
RU2326870C2 (ru) * 2003-08-04 2008-06-20 Валерий Хажмуратович ЖИЛОВ Применение циклических биоизостеров производных пуриновой системы для лечения расстройств, вызванных нарушениями нитрергической и дофаминергической систем
PL231885B1 (pl) 2009-01-16 2019-04-30 Abidopharma Spolka Z Ograniczona Odpowiedzialnoscia Sposób wytwarzania soli 5-amino-2,3-dihydroftalazyno-1,4-di onu z metalami alkalicznymi, ich kompozycje farmaceutyczne i ich zastosowanie
WO2010091257A1 (en) 2009-02-06 2010-08-12 Bach Pharma, Inc. Pharmaceutical grade phthalazinediones, process for their preparation and pharmaceutical compositions containing them
PT2542535E (pt) 2010-03-01 2014-08-25 Metriopharm Ag Formas cristalinas para sal de sódio de 5-amino-2,3-di hidroftalazino-1,4-diona, preparações farmacêuticas contendo o mesmo e processo para a produção das ditas formas
CN102382115B (zh) * 2011-10-14 2014-06-11 浙江工业大学 一种吲唑并酞嗪化合物的合成方法
RU2532128C1 (ru) * 2013-05-22 2014-10-27 Закрытое акционерное общество "Управляющая компания "Световит" Способ получения о-люминолятов щелочных металлов
JP2017537958A (ja) 2014-12-18 2017-12-21 メトリオファーム アーゲー ５−アミノ−２，３−ジヒドロフタラジン１，４−ジオンナトリウム塩の結晶形態、同一物を含む医薬製剤、及びこの形態の製造ための方法
CN109563052A (zh) * 2016-02-16 2019-04-02 麦翠奥制药公司 5-氨基-2,3-二氢噻嗪-1,4-二酮的结晶体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2420702A (en) * 1944-06-28 1947-05-20 British Celanese Amino-aliphatic hydrazines and process for making same
US3007937A (en) * 1959-06-04 1961-11-07 Du Pont Synthesis of 5-(4-aminobutyl) hydantoin
BE733845A (es) * 1968-06-12 1969-11-03
US3870792A (en) * 1972-07-24 1975-03-11 Michiro Inoue Certain dihydrophthalizines for treating hemorrhage and thrombosis
US4318505A (en) * 1980-08-12 1982-03-09 Cordell Jr Charles E Disposable suitcase
DE3164437D1 (en) * 1980-08-25 1984-08-02 Kabivitrum Ab Peptide substrates for determination of protease activity
HU181184B (en) * 1980-09-12 1983-06-28 Eszakmagyar Vegyimuevek Composition for replacing kinetine,the effect and membraneactivity of which is similar to citokinine,which composition improves plant productivity,quantity of protein-nitrogen and anion-absorptivity

Also Published As

Publication number Publication date
EP0612733A1 (en) 1994-08-31
CH683966A5 (it) 1994-06-30
US5512573A (en) 1996-04-30
JPH07188022A (ja) 1995-07-25
DE69413090T2 (de) 1999-08-19
EP0612733B1 (en) 1998-09-09
DE69413090D1 (de) 1998-10-15
ATE170847T1 (de) 1998-09-15
JP2725994B2 (ja) 1998-03-11

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