ES2125982T3 - Prueba inmunologica turbidimetrica de velocidad inicial. - Google Patents

Prueba inmunologica turbidimetrica de velocidad inicial.

Info

Publication number
ES2125982T3
ES2125982T3 ES93912327T ES93912327T ES2125982T3 ES 2125982 T3 ES2125982 T3 ES 2125982T3 ES 93912327 T ES93912327 T ES 93912327T ES 93912327 T ES93912327 T ES 93912327T ES 2125982 T3 ES2125982 T3 ES 2125982T3
Authority
ES
Spain
Prior art keywords
analyte
liquid medium
carried out
initial rate
turbidimetric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93912327T
Other languages
English (en)
Inventor
Elizabeth K Kearns
Chan S Oh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of ES2125982T3 publication Critical patent/ES2125982T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

SE DESCRIBE UN METODO DE INMUNOENSAYO FOTOMETRICO DE REGIMEN INICIAL, UTIL PARA DETECTAR Y CUANTIFICAR ANALISIS EN VARIOS FLUIDOS FISIOLOGICOS. EL METODO SE REALIZA MEDIANTE LA COMBINACION EN UN MEDIO LIQUIDO DE UNA MUESTRA NO DILUIDA DE FLUIDO FISIOLOGICO CONTENIENDO ANALISIS, TALES COMO SUERO, Y UN EXCESO DE UN ANTICUERPO ANTI-ANALITO. SE MIDE EN TIEMPO REAL UN REGIMEN INICIAL SUSTANCIALMENTE CONSTANTE DE AUMENTO DE LA VISCOSIDAD DEL MEDIO LIQUIDO, DEBIDO A LA REACCION RESULTANTE DE INMUNOPRECIPITACION, Y SE COMPARA CON UNA CURVA DE CALIBRACION PREPARADA DE CONCENTRACIONES DE ANALITO CONOCIDAS PARA DETECTAR Y CUANTIFICAR EL ANALITO. DETECCION Y CUANTIFICACION DE NUMEROSOS ANALITO INCLUYENDO HAPTENS (ANTIGENOS PARCIALES), MEDICINAS Y PROTEINAS, EN UNA AMPLIA VARIEDAD DE FLUIDOS FISIOLOGICOS PUEDEN REALIZARSE RAPIDAMENTE CON EL PRESENTE METODO.
ES93912327T 1992-07-17 1993-04-21 Prueba inmunologica turbidimetrica de velocidad inicial. Expired - Lifetime ES2125982T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/916,519 US5371021A (en) 1992-07-17 1992-07-17 Initial rate photometric method for immunoassay

Publications (1)

Publication Number Publication Date
ES2125982T3 true ES2125982T3 (es) 1999-03-16

Family

ID=25437408

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93912327T Expired - Lifetime ES2125982T3 (es) 1992-07-17 1993-04-21 Prueba inmunologica turbidimetrica de velocidad inicial.

Country Status (9)

Country Link
US (2) US5371021A (es)
EP (1) EP0604606B1 (es)
JP (1) JPH06511088A (es)
AT (1) ATE173829T1 (es)
AU (1) AU669904B2 (es)
CA (1) CA2116687A1 (es)
DE (1) DE69322242T2 (es)
ES (1) ES2125982T3 (es)
WO (1) WO1994002853A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284472B1 (en) 1998-10-05 2001-09-04 Dade Behring Inc. Method for extending the range of an immunoassay
WO2004073492A2 (en) * 2003-02-14 2004-09-02 Massachusetts Eye And Ear Infirmary Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof
ITMI20030971A1 (it) * 2003-05-15 2004-11-16 Solvay Solexis Spa Preparazione di perfluoropolieteri aventi almeno un terminale -ch2oh oppure -ch(cf3)oh.
EP1496362B1 (en) * 2003-07-09 2006-12-13 Matsushita Electric Industrial Co., Ltd. Turbidimetric immunoassay and an apparatus therefor
WO2005052583A1 (ja) * 2003-11-28 2005-06-09 Olympus Corporation 分析対象物質の検出方法
GB2426050A (en) * 2005-05-09 2006-11-15 Orion Diagnostica Oy Method of measuring binding rate using sonication
EP2005170A1 (en) * 2006-03-24 2008-12-24 Aokin Ag Use of additives to lower the rate of a binding reaction
WO2008031051A2 (en) * 2006-09-08 2008-03-13 United Therapeutics Corporation Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers
CN105866423A (zh) * 2009-05-14 2016-08-17 牛津大学之校长及学者 使用一组新型低丰度人类血浆蛋白生物标记对肝纤维化进行临床诊断
RU2650424C1 (ru) * 2017-02-27 2018-04-13 Акционерное Общество "Концерн "Океанприбор" Концентратомер подвижных инфузорий в жидких средах

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4305665A (en) * 1975-01-29 1981-12-15 Baxter Travenol Laboratories, Inc. Nephelometer and nephelometer method for assaying immunochemical complex
US4268171A (en) * 1977-07-18 1981-05-19 Beckman Instruments, Inc. Method determining concentration in rate nephelometric immunochemical analysis
JPS54108693A (en) * 1978-02-14 1979-08-25 Mitsubishi Chem Ind Method and device for optically measuring antigennantibody reaction
JPS54109494A (en) * 1978-02-16 1979-08-28 Teikoku Hormone Mfg Co Ltd Method of measuring antigennantibody reaction
US4204837A (en) * 1978-03-14 1980-05-27 Beckman Instruments, Inc. Method of rate immunonephelometric analysis
US4205954A (en) * 1978-05-26 1980-06-03 Warner-Lambert Company Kinetic latex agglutinometry
JPS5544903A (en) * 1978-09-26 1980-03-29 Chugai Pharmaceut Co Ltd Method of quantitatively analyzing low molecular substance in humor
DE2901327B1 (de) * 1979-01-15 1980-07-24 Boehringer Mannheim Gmbh Verfahren zur Bestimmung eines opsonierenden oberflaechenbindenden alpha?-Glykoproteins
JPS57175957A (en) * 1981-04-24 1982-10-29 Chugai Pharmaceut Co Ltd Measuring method and device for antigen- antibody reaction
US4604365A (en) * 1981-06-02 1986-08-05 Electro-Nucleonics, Inc. Immunoprecipitation assay
US4766083A (en) * 1982-04-04 1988-08-23 Wako Pure Chemical Industries, Ltd. Method for the photometric determination of biological agglutination
DE3212658C3 (de) * 1982-04-05 1993-08-19 American Hospital Supply Corp Verfahren zur antigen-bestimmung
US4521521A (en) * 1983-03-11 1985-06-04 E. I. Du Pont De Nemours And Company Particle reagent size distribution measurements for immunoassay
US4554257A (en) * 1983-04-29 1985-11-19 Aladjem Frederick J Assaying immunoreactive and like substances by measurement of aggregate classes
JPH0736016B2 (ja) * 1984-05-11 1995-04-19 和光純薬工業株式会社 免疫グロブリンの定量方法
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
DE3615384A1 (de) * 1985-05-08 1986-11-13 Nissui Seiyaku K.K., Tokio/Tokyo Verfahren zur bestimmung des rheumafaktors und denaturiertes, menschliches (gamma)-globulin fuer das verfahren
JPH0660901B2 (ja) * 1985-08-30 1994-08-10 東ソー株式会社 酵素免疫測定法
US4835110A (en) * 1985-12-23 1989-05-30 Beckman Instruments, Inc. Method for enhancing analysis timing in kinetic nephelometry
JP2524511B2 (ja) * 1985-12-23 1996-08-14 ベツクマン インスツルメンツ インコ−ポレ−テツド 自動免疫化学分析装置及び方法
US5169757A (en) * 1987-05-20 1992-12-08 Carleton University Antibodies or antigens bound to a macroporous hydrophobic synthetic polymer cloth for immunological techniques
AU2128388A (en) * 1987-07-21 1989-02-13 Coulter Electronics Inc. Improved turbidimetric rate inhibition assay for haptens
ES2056936T3 (es) * 1987-09-30 1994-10-16 Beckman Instruments Inc Conjugado bidentado y metodo de utilizacion del mismo.
US5019999A (en) * 1988-09-30 1991-05-28 Technicon Instruments Corporation Immunoanalysis method for discriminating between antigen excess and antibody excess conditions
DE3900493A1 (de) * 1989-01-10 1990-07-12 Thomae Gmbh Dr K Verfahren zur bestimmung der fibrinolytischen gesamtaktivitaet im plasma

Also Published As

Publication number Publication date
WO1994002853A1 (en) 1994-02-03
AU4291393A (en) 1994-02-14
ATE173829T1 (de) 1998-12-15
AU669904B2 (en) 1996-06-27
EP0604606A1 (en) 1994-07-06
EP0604606B1 (en) 1998-11-25
US5371021A (en) 1994-12-06
JPH06511088A (ja) 1994-12-08
DE69322242T2 (de) 1999-04-22
DE69322242D1 (de) 1999-01-07
CA2116687A1 (en) 1994-02-03
US5583055A (en) 1996-12-10

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