ES2133477T3 - Forma de dosificacion que comprende un antigeno y una forma salina de un derivado de acido organico de un esterol. - Google Patents

Forma de dosificacion que comprende un antigeno y una forma salina de un derivado de acido organico de un esterol.

Info

Publication number
ES2133477T3
ES2133477T3 ES94201844T ES94201844T ES2133477T3 ES 2133477 T3 ES2133477 T3 ES 2133477T3 ES 94201844 T ES94201844 T ES 94201844T ES 94201844 T ES94201844 T ES 94201844T ES 2133477 T3 ES2133477 T3 ES 2133477T3
Authority
ES
Spain
Prior art keywords
antigen
dose
type
sterol
organic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94201844T
Other languages
English (en)
Inventor
Mircea C Popescu
Marie S Recine
Carl L Alving
Leonard F Estis
Lynn D Keyes
Andrew S Janoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ES2133477T3 publication Critical patent/ES2133477T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN TIPO DE DOSIS DE INMUNIZACION DE LA GRIPE CONSTA DE UN LIPOSOMA Y DE UN ANTIGENO DE LA GRIPE, PARTICULARMENTE EL FRAGMENTO DE HEMAGGLUTININ O BROMELAIN, EN DONDE DICHO LIPOSOMA Y ANTIGENO SE PRESENTAN EN UNA DOSIS DE INMUNIZACION. ADICIONALMENTE, UN TIPO DE DOSIS, QUE INCLUYE TAL TIPO PARTICULARMENTE ADAPTADO PARA PRODUCIR UNA RESPUESTA INMUNE, CONSTA DE UN TIPO DE SAL DE UN DERIVADO DE ACIDO ORGANICO DE UN ESTEROL Y UN ANTIGENO EN DONDE DICHO DERIVADO DE ACIDO ORGANICO DE UN ESTEROL Y UN ANTIGENO ESTAN PRESENTES EN UNA DOSIS DE INMUNIZACION, Y METODO DE USO. ADEMAS, UN TIPO DE DOSIS, QUE INCLUYE TAL TIPO PARTICULARMENTE ADAPTADO PARA PRODUCIR UNA RESPUESTA INMUNE, QUE CONSTA OPCIONALMENTE DE LIPOSOMAS DE COLESTEROL DE DIMIRISTOLIFOSFATIDICOLINA (DMPC) EN UN GEL DE HIDROXIDO DE ALUMINIO, Y UN ANTIGENO EN DONDE DICHO COLESTEROL DMPC Y ANTIGENO SE PRESENTAN EN UNA DOSIS DE INMUNIZACION, Y METODO DE USO.
ES94201844T 1988-08-25 1989-08-25 Forma de dosificacion que comprende un antigeno y una forma salina de un derivado de acido organico de un esterol. Expired - Lifetime ES2133477T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23670288A 1988-08-25 1988-08-25
US23670188A 1988-08-25 1988-08-25
US39777789A 1989-08-23 1989-08-23

Publications (1)

Publication Number Publication Date
ES2133477T3 true ES2133477T3 (es) 1999-09-16

Family

ID=27398905

Family Applications (2)

Application Number Title Priority Date Filing Date
ES89402343T Expired - Lifetime ES2069600T3 (es) 1988-08-25 1989-08-25 Vacuna de la influenza y nuevos adyuvantes.
ES94201844T Expired - Lifetime ES2133477T3 (es) 1988-08-25 1989-08-25 Forma de dosificacion que comprende un antigeno y una forma salina de un derivado de acido organico de un esterol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES89402343T Expired - Lifetime ES2069600T3 (es) 1988-08-25 1989-08-25 Vacuna de la influenza y nuevos adyuvantes.

Country Status (9)

Country Link
EP (2) EP0356339B1 (es)
JP (1) JPH04500203A (es)
AT (2) ATE119037T1 (es)
AU (2) AU627226B2 (es)
CA (1) CA1337332C (es)
DE (2) DE68921389T2 (es)
ES (2) ES2069600T3 (es)
GR (1) GR3031244T3 (es)
NZ (2) NZ230423A (es)

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AU4186189A (en) 1990-03-23
CA1337332C (en) 1995-10-17
EP0356339B1 (en) 1995-03-01
GR3031244T3 (en) 1999-12-31
AU627226B2 (en) 1992-08-20
ES2069600T3 (es) 1995-05-16
DE68929033D1 (de) 1999-08-19
JPH04500203A (ja) 1992-01-16
DE68921389D1 (de) 1995-04-06
ATE182080T1 (de) 1999-07-15
DE68921389T2 (de) 1995-06-29
NZ230423A (en) 1993-08-26
AU631377B2 (en) 1992-11-26
EP0356339A1 (en) 1990-02-28
EP0626169A3 (en) 1995-12-13
ATE119037T1 (de) 1995-03-15
DE68929033T2 (de) 1999-12-30
EP0626169B1 (en) 1999-07-14
NZ241926A (en) 1993-08-26
AU4221489A (en) 1990-03-23
EP0626169A2 (en) 1994-11-30

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