ES2092808T3 - Cuerpos solidos con contenido en principio activo con una estructura a base de macromoleculas hidrofilas y procedimiento para su produccion. - Google Patents

Cuerpos solidos con contenido en principio activo con una estructura a base de macromoleculas hidrofilas y procedimiento para su produccion.

Info

Publication number
ES2092808T3
ES2092808T3 ES93902034T ES93902034T ES2092808T3 ES 2092808 T3 ES2092808 T3 ES 2092808T3 ES 93902034 T ES93902034 T ES 93902034T ES 93902034 T ES93902034 T ES 93902034T ES 2092808 T3 ES2092808 T3 ES 2092808T3
Authority
ES
Spain
Prior art keywords
procedure
production
active substance
structure based
substance content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902034T
Other languages
English (en)
Inventor
Jens-Christian Wunderlich
Ursula Schick
Jurgen Werry
Jurgen Freidenreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfatec Pharma GmbH
Original Assignee
Alfatec Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27435369&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2092808(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4201179A external-priority patent/DE4201179A1/de
Priority claimed from DE4201173A external-priority patent/DE4201173C2/de
Application filed by Alfatec Pharma GmbH filed Critical Alfatec Pharma GmbH
Application granted granted Critical
Publication of ES2092808T3 publication Critical patent/ES2092808T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Glanulating (AREA)

Abstract

LA INVENCION SE REFIERE A CUERPOS MOLDEADOS CON DOSIFICACION PRECISA, POR EJEMPLO GRANULADOS O PELLETS, CONTENIENDO MACROMOLECULAS HIDROFILICAS, SUSTANCIAS ACTIVAS Y, OPCIONALMENTE, OTROS AGENTES DE FORMACION DE ESTRUCTURA ACEPTABLES FARMACEUTICAMENTE Y SUSTANCIAS AUXILIARES, ESTANDO DISUELTA LA SUSTANCIA ACTIVA EN FORMA SUSPENDIDA O EMULSIFICADA CON UNA MATRIZ. LA INVENCION SE REFIERE TAMBIEN A UN PROCESO PARA LA ELABORACION DE TALES CUERPOS MOLDEADOS, SIENDO EL PROCESO PARTICULARMENTE DE COSTE EFECTIVO Y ACEPTABLE AL MEDIO AMBIENTE. CON UTILIZACION DE CUERPOS MOLDEADOS COMO MEDICAMENTOS EN DONDE SE HA INCREMENTADO LA BIODISPONIBILIDAD, CONSERVABILIDAD Y COMPATIBILIDAD. ADICIONALMENTE, LOS CUERPOS MOLDEADOS DESCRITOS, O SU MEZCLA, SON TAMBIEN UTILIZADOS EN PRODUCTOS FINALES O INTERMEDIOS DE PREPARACION PARA SU UTILIZACION EN PRODUCTOS FARMACEUTICOS, COSMETICOS, DIAGNOSIS, ANALISIS O CUIDADO DIETETICO DE LA SALUD.
ES93902034T 1992-01-17 1993-01-18 Cuerpos solidos con contenido en principio activo con una estructura a base de macromoleculas hidrofilas y procedimiento para su produccion. Expired - Lifetime ES2092808T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4201179A DE4201179A1 (de) 1992-01-17 1992-01-17 Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung
DE4201173A DE4201173C2 (de) 1992-01-17 1992-01-17 Akutarzneimittel in Form von Dihydropyridinderivaten enthaltenden Pellets und ihre Herstellung
US07/876,877 US5384129A (en) 1992-01-17 1992-04-30 Pellets containing dihydropyridine derivatives process for the production thereof and use as rapid action dosage in heart and circulatory diseases
US07/876,864 US5405616A (en) 1992-01-17 1992-04-30 Means for containing active substances, having a shell of hydrophilic macromolecules, active substances and process for preparation thereof

Publications (1)

Publication Number Publication Date
ES2092808T3 true ES2092808T3 (es) 1996-12-01

Family

ID=27435369

Family Applications (2)

Application Number Title Priority Date Filing Date
ES93902034T Expired - Lifetime ES2092808T3 (es) 1992-01-17 1993-01-18 Cuerpos solidos con contenido en principio activo con una estructura a base de macromoleculas hidrofilas y procedimiento para su produccion.
ES95113398T Expired - Lifetime ES2133633T3 (es) 1992-01-17 1993-01-18 Procedimiento para la produccion de polvos, granulados o peletes que contienen una sustancia activa, con una estructura a base de macromoleculas hidrofilas, y su utilizacion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES95113398T Expired - Lifetime ES2133633T3 (es) 1992-01-17 1993-01-18 Procedimiento para la produccion de polvos, granulados o peletes que contienen una sustancia activa, con una estructura a base de macromoleculas hidrofilas, y su utilizacion.

Country Status (10)

Country Link
EP (2) EP0621777B1 (es)
JP (1) JPH07502736A (es)
AT (2) ATE142484T1 (es)
AU (1) AU679906B2 (es)
CA (1) CA2128244C (es)
DE (2) DE59309678D1 (es)
DK (2) DK0701815T3 (es)
ES (2) ES2092808T3 (es)
GR (2) GR3021223T3 (es)
WO (1) WO1993013757A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714575B1 (fr) * 1994-01-03 1996-02-02 Rhone Poulenc Nutrition Animal Nouveaux granulés contenant des organismes vivant pour l'alimentation animale.
SE9704401D0 (sv) * 1997-11-28 1997-11-28 Astra Ab Matrix pellets for greasy, oily or sticky drug substances
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
EP1243318B1 (de) * 2001-03-22 2005-03-02 Cognis Iberia, S.L. Mikrokapseln (VII)
US6858580B2 (en) 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
AU2003236521A1 (en) 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
FR2843302B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
FR2843301B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
JP2006504799A (ja) * 2002-10-16 2006-02-09 ドクトル ズベラック スキン ウント ヘルス ケア アクチェンゲゼルシャフト 形成物の身体表面への利用法
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
BRPI0513508B1 (pt) 2004-07-19 2021-06-01 Biocon Limited Conjugados de insulina-oligômero, formulações e usos desses
FR2887455B1 (fr) * 2005-06-28 2007-08-10 Sanofi Aventis Sa Formulation a liberation prolongee de principes actifs de medicaments
US9308175B2 (en) 2006-09-15 2016-04-12 Echo Pharmaceuticals B.V. Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances
EP2061427B1 (en) * 2006-09-15 2011-07-20 Echo Pharmaceuticals B.V. Granulate containing a pharmaceutically active substance and an emulsifier and method for its manufacture
US8273376B2 (en) 2006-11-17 2012-09-25 Da Volterra Colonic delivery of metallo-dependent enzymes
BRPI1001091A2 (pt) 2009-04-22 2011-03-22 Dr Suwelack Skin & Health Care Ag artigo moldado revestido secado por congelamento
ES2786506T3 (es) * 2012-08-01 2020-10-13 Zahra Tavakoli Composiciones congeladas fluidas que comprenden un agente terapéutico
ITMI20122145A1 (it) * 2012-12-14 2014-06-15 Velleja Res Srl Composizioni per uso orale contenenti idrolizzati di collagene, di elastina e vitamina c favorenti la deposizione di matrice extra-cellulare
LU102656B1 (de) 2021-03-11 2022-09-12 Prosecur Gmbh Flüssiges Nahrungsergänzungsmittel zur Immunstimulation, Verfahren zu dessen Herstellung sowie Verwendung

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US5215756A (en) * 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution
ATE132036T1 (de) 1992-01-17 1996-01-15 Alfatec Pharma Gmbh Verfahren zur herstellung von weichgelatinekapseln nach einem tropfverfahren
EP0621775B1 (de) 1992-01-17 1997-08-06 ALFATEC-PHARMA GmbH Peptidarzneistoffe enthaltende pellets und ihre herstellung sowie deren verwendung
ES2102637T3 (es) 1992-01-17 1997-08-01 Alfatec Pharma Gmbh Cuerpos moldeados criogranulados que contienen un extracto de sustancias vegetales activas y su utilizacion farmaceutica o cosmetica.
DE4221880A1 (de) * 1992-07-03 1994-01-05 Alfatec Pharma Gmbh Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen

Also Published As

Publication number Publication date
EP0701815B1 (de) 1999-06-30
ES2133633T3 (es) 1999-09-16
EP0621777B1 (de) 1996-09-11
DK0621777T3 (da) 1996-10-21
EP0621777A1 (de) 1994-11-02
AU679906B2 (en) 1997-07-17
CA2128244A1 (en) 1993-07-22
DE59303759D1 (de) 1996-10-17
EP0701815A1 (de) 1996-03-20
DK0701815T3 (da) 2000-02-07
ATE142484T1 (de) 1996-09-15
DE59303759C5 (de) 2009-04-09
DE59309678D1 (de) 1999-08-05
AU3343293A (en) 1993-08-03
JPH07502736A (ja) 1995-03-23
GR3030675T3 (en) 1999-11-30
ATE181666T1 (de) 1999-07-15
GR3021223T3 (en) 1997-01-31
WO1993013757A1 (de) 1993-07-22
CA2128244C (en) 1998-09-22

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