ES2134846T3 - Formulacion de antibiotico y uso para infecciones resistentes a farmacos. - Google Patents

Formulacion de antibiotico y uso para infecciones resistentes a farmacos.

Info

Publication number
ES2134846T3
ES2134846T3 ES93911272T ES93911272T ES2134846T3 ES 2134846 T3 ES2134846 T3 ES 2134846T3 ES 93911272 T ES93911272 T ES 93911272T ES 93911272 T ES93911272 T ES 93911272T ES 2134846 T3 ES2134846 T3 ES 2134846T3
Authority
ES
Spain
Prior art keywords
formulation
drug resistant
resistant infections
antibiotic formulation
aminoglycoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93911272T
Other languages
English (en)
Inventor
Evan M Hersh
Eskild A Petersen
Richard T Proffitt
Kevin R Bracken
Su-Ming Chiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2134846T3 publication Critical patent/ES2134846T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UNA FORMULACION DE AMINOGLICOSIDO LIPOSOMAL QUE CONSTA DE UN LIPIDO NEUTRO, LIPIDOS CARGADOS NEGATIVAMENTE Y UN ESTEROL. LA FORMULACION CONTIENE VESICULAS UNILAMINARES QUE TIENEN UN TAMAÑO MEDIO POR DEBAJO DE 100 NM. SE DESCRIBE UN PROCESO DE FABRICACION DE LIPOSOMAS CONTENIENDO UN AMINOGLICOSIDO DONDE LA TEMPERATURA DE HIDRATACION ESTA SIGNIFICATIVAMENTE POR DEBAJO DE LA TEMPERATURA DE TRANSICION DE LA FORMULACION. UN METODO PARA EL TRATAMIENTO DE BACTERIAS SUSCEPTIBLES Y RESISTENTES AL FARMACO.
ES93911272T 1992-12-02 1993-05-11 Formulacion de antibiotico y uso para infecciones resistentes a farmacos. Expired - Lifetime ES2134846T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1992/010591 WO1994012155A1 (en) 1992-12-02 1992-12-02 Antibiotic formulation and process

Publications (1)

Publication Number Publication Date
ES2134846T3 true ES2134846T3 (es) 1999-10-16

Family

ID=22231603

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93911272T Expired - Lifetime ES2134846T3 (es) 1992-12-02 1993-05-11 Formulacion de antibiotico y uso para infecciones resistentes a farmacos.

Country Status (11)

Country Link
US (1) US5756121A (es)
EP (1) EP0671904B1 (es)
JP (2) JP4084846B2 (es)
AT (1) ATE183082T1 (es)
AU (2) AU3244393A (es)
CA (1) CA2150832C (es)
DE (1) DE69326017T2 (es)
DK (1) DK0671904T3 (es)
ES (1) ES2134846T3 (es)
GR (1) GR3031548T3 (es)
WO (2) WO1994012155A1 (es)

Families Citing this family (24)

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US5958449A (en) * 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
US6146890A (en) * 1994-07-03 2000-11-14 Danon; David Method and system for cultivating macrophages
US5662929A (en) * 1994-12-23 1997-09-02 Universite De Montreal Therapeutic liposomal formulation
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
DE69912441T2 (de) 1998-08-19 2004-08-19 Skyepharma Canada Inc., Verdun Injizierbare wässerige propofoldispersionen
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes
JP2005530704A (ja) * 2002-03-05 2005-10-13 トランセイブ， インク． 細胞内感染を予防及び治療するための吸入システム
PT1581236E (pt) * 2002-10-29 2013-12-24 Insmed Inc Libertação prolongada de anti-infecciosos
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
EP3067047B1 (en) 2005-12-08 2022-04-20 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
PL2852391T3 (pl) 2012-05-21 2022-04-11 Insmed Incorporated Układy do leczenia infekcji płuc
US20150297725A1 (en) 2012-07-30 2015-10-22 Rutgers, The State University Of New Jersey Cochleates made with soy phosphatidylserine
US10124066B2 (en) 2012-11-29 2018-11-13 Insmed Incorporated Stabilized vancomycin formulations
LT3466432T (lt) * 2014-05-15 2020-12-28 Insmed Incorporated Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti
WO2019156179A1 (ja) * 2018-02-07 2019-08-15 Ｊｆｅスチール株式会社 高Ｍｎ鋼およびその製造方法
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
JP7449275B2 (ja) 2018-05-02 2024-03-13 インスメッド インコーポレイテッド リポソーム薬物製剤の製造方法

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JPS5782311A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
FR2534487B1 (fr) * 1982-10-15 1988-06-10 Dior Christian Parfums Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede
US4981692A (en) * 1983-03-24 1991-01-01 The Liposome Company, Inc. Therapeutic treatment by intramammary infusion
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
CA1237670A (en) * 1983-05-26 1988-06-07 Andrew S. Janoff Drug preparations of reduced toxicity
CA1237671A (en) * 1983-08-01 1988-06-07 Michael W. Fountain Enhancement of pharmaceutical activity
JPH0753661B2 (ja) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
JPS6176414A (ja) * 1984-09-21 1986-04-18 Shionogi & Co Ltd リポソーム製剤の製法
US4753788A (en) * 1985-01-31 1988-06-28 Vestar Research Inc. Method for preparing small vesicles using microemulsification
US5409704A (en) * 1985-06-26 1995-04-25 The Liposome Company, Inc. Liposomes comprising aminoglycoside phosphates and methods of production and use
US5023087A (en) * 1986-02-10 1991-06-11 Liposome Technology, Inc. Efficient method for preparation of prolonged release liposome-based drug delivery system
US5043107A (en) * 1986-08-21 1991-08-27 Vestar Research, Inc. Preparation small unilamellar vesicles including polyene antifungal antibiotics
US4933121A (en) * 1986-12-10 1990-06-12 Ciba Corning Diagnostics Corp. Process for forming liposomes
IL97538A (en) * 1986-12-23 1995-03-15 Liposome Co Inc Multilamellar liposomes containing nonphosphate guanindino aminoglycosides and their preparation.
US5043166A (en) * 1987-01-09 1991-08-27 Hadasit Medical Research, Inc. Liposome/anthraquinone drug composition and method
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US5043165A (en) * 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
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CA2093381A1 (en) * 1992-04-07 1993-10-08 Hideyuki Sawahara Liposome formulation and process for production thereof
PT100486B (pt) * 1992-05-14 1999-07-30 Ineti Inst Nac Engenh E Tecnol Aminoglucosidos lipossomais com altas eficacia de encapsulacao e actividade terapeutica, nomeadamente a netilmicina, e processo para a sua preparcao
US5276452A (en) * 1992-06-24 1994-01-04 Raytheon Company Scan compensation for array antenna on a curved surface
JP3325665B2 (ja) * 1993-09-10 2002-09-17 三菱化学株式会社 オレフィン重合用触媒およびこれを用いたオレフィン重合体の製造方法

Also Published As

Publication number Publication date
CA2150832C (en) 2000-01-11
ATE183082T1 (de) 1999-08-15
WO1994012156A1 (en) 1994-06-09
JPH09506855A (ja) 1997-07-08
AU3244393A (en) 1994-06-22
US5756121A (en) 1998-05-26
DE69326017T2 (de) 1999-12-23
JP4084846B2 (ja) 2008-04-30
AU668179B2 (en) 1996-04-26
EP0671904A1 (en) 1995-09-20
WO1994012155A1 (en) 1994-06-09
EP0671904B1 (en) 1999-08-11
AU4246393A (en) 1994-06-22
JP2005320341A (ja) 2005-11-17
DK0671904T3 (da) 1999-12-06
CA2150832A1 (en) 1994-06-09
DE69326017D1 (de) 1999-09-16
GR3031548T3 (en) 2000-01-31

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