ES2137456T3 - Agente de tratamiento de las enfermedades hepato-biliares. - Google Patents

Agente de tratamiento de las enfermedades hepato-biliares.

Info

Publication number
ES2137456T3
ES2137456T3 ES95303718T ES95303718T ES2137456T3 ES 2137456 T3 ES2137456 T3 ES 2137456T3 ES 95303718 T ES95303718 T ES 95303718T ES 95303718 T ES95303718 T ES 95303718T ES 2137456 T3 ES2137456 T3 ES 2137456T3
Authority
ES
Spain
Prior art keywords
treatment
liver
agent
biliary diseases
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95303718T
Other languages
English (en)
Inventor
Ryuji Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R Tech Ueno Ltd
Original Assignee
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Tech Ueno Ltd filed Critical R Tech Ueno Ltd
Application granted granted Critical
Publication of ES2137456T3 publication Critical patent/ES2137456T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EL OBJETO DE LA INVENCION ES SUMINISTRAR UNA COMPOSICION FARMACEUTICA PARA EL TRATAMIENTO DE ENFERMEDADES HEPATOBILIARES CON EFECTOS LATERALES REDUCIDOS TALES COMO LA DIARREA, QUE COMPRENDE 16, 16-DIFLUORO-QUETO-PGS QUE TIENEN AL MENOS UN GRUPO DE METIL O UN GRUPO DE ETIL SOBRE EL ATOMO DE CARBONO EN LA POSICION 17 O 18 O ADYACENTE AL GRUPO DE METIL TERMINAL DE LA CADENA {OE} COMO COMPONENTE ESENCIAL.
ES95303718T 1994-06-03 1995-05-31 Agente de tratamiento de las enfermedades hepato-biliares. Expired - Lifetime ES2137456T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12248794 1994-06-03

Publications (1)

Publication Number Publication Date
ES2137456T3 true ES2137456T3 (es) 1999-12-16

Family

ID=14837070

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95303718T Expired - Lifetime ES2137456T3 (es) 1994-06-03 1995-05-31 Agente de tratamiento de las enfermedades hepato-biliares.

Country Status (14)

Country Link
US (1) US5739161A (es)
EP (1) EP0690049B1 (es)
KR (1) KR100260573B1 (es)
CN (1) CN1076605C (es)
AT (1) ATE182884T1 (es)
AU (1) AU690241B2 (es)
CA (1) CA2150287C (es)
DE (1) DE69511181T2 (es)
DK (1) DK0690049T3 (es)
ES (1) ES2137456T3 (es)
FI (1) FI952721A7 (es)
GR (1) GR3031066T3 (es)
NO (1) NO308993B1 (es)
NZ (1) NZ272234A (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE29717252U1 (de) * 1997-09-26 1998-02-19 Dr. Falk Pharma GmbH, 79108 Freiburg Arzneimittelkit aus einem Budesonid-haltigen und einem Ursodesoxycholsäure-haltigen Arzneimittel zur Behandlung von cholestatischen Lebererkrankungen
NZ336362A (en) * 1997-10-13 2001-01-26 R Tech Ueno Ltd Use of a 15-keto-prostaglandin compound as a portal hypertension inhibitor
TWI225398B (en) 1999-07-14 2004-12-21 R Tech Ueno Ltd Composition for treatment of external secretion disorders
RU2695274C3 (ru) 1999-10-15 2020-11-09 Сукампо Аг Новые композиции и способы их стабилизации
EP1267882B1 (en) 2000-03-24 2009-04-15 Sucampo AG Prostaglandins for the treatment of eye disease caused by light irradiation like photoretinitis
NZ521784A (en) * 2000-04-06 2005-04-29 Sucampo Ag Bile secretion promoting composition
US6414016B1 (en) 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
EP1420794B1 (en) * 2001-08-31 2017-12-27 Sucampo AG Prostaglandin analogs as chloride channel openers
AR037524A1 (es) * 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
TWI263505B (en) * 2001-11-19 2006-10-11 Sucampo Ag Pharmaceutical composition comprising a C1C-2 channel opener
DK1562604T3 (da) * 2002-10-23 2012-04-02 Sucampo Ag Prostaglandinforbindelser til behandling af fedme
BRPI0317740B8 (pt) 2002-12-27 2021-05-25 Sucampo Ag uso do composto 13,14-diidro-15-ceto-16,16-diflúorprostaglandina e1
ATE489096T1 (de) * 2003-07-03 2010-12-15 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
ES2431640T3 (es) 2003-08-21 2013-11-27 Sucampo Ag Composición oftálmica que comprende éster isopropílico de unoprostona y un agente de viscosidad
JP4690814B2 (ja) * 2004-08-02 2011-06-01 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
DK1841433T3 (da) * 2005-01-27 2012-01-16 Sucampo Ag Præparat til behandling af lidelser i centralnervesystemet
DE602006018583D1 (de) * 2005-03-04 2011-01-13 Sucampo Ag Verfahren und zusammensetzung zur behandlung von peripheren gefässkrankheiten
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
WO2006109881A1 (en) * 2005-04-12 2006-10-19 Sucampo Ag Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders
EP1984027B1 (en) * 2006-01-24 2015-12-30 R-Tech Ueno, Ltd. Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
CA2637274C (en) 2006-01-24 2013-06-04 R-Tech Ueno, Ltd. Soft-gelatin capsule formulation
EP2735566A1 (en) * 2006-02-07 2014-05-28 R-Tech Ueno, Ltd. Method for preparing prostaglandin derivative
JP4648340B2 (ja) * 2006-02-07 2011-03-09 株式会社アールテック・ウエノ １５−ケトプロスタグランジンｅ誘導体の製造法
CA2642744C (en) * 2006-02-28 2015-02-24 Sucampo Ag Method and composition for treating chronic obstructive pulmonary disease
JPWO2007105691A1 (ja) 2006-03-13 2009-07-30 株式会社アールテック・ウエノ 水性組成物
US8871752B2 (en) * 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
US8609729B2 (en) 2009-04-15 2013-12-17 Sucampo Ag Method for treating macular degeneration
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
CN103561748A (zh) 2011-04-07 2014-02-05 苏坎波公司 治疗眼疲劳的方法
BR112013026644A2 (pt) * 2011-04-19 2016-12-27 Sucampo Ag método para a modulação da atividade de citocina
TWI540125B (zh) * 2011-07-01 2016-07-01 艾德克 上野股份有限公司 脂肪酸衍生物的製備方法
CN102875586A (zh) * 2011-07-11 2013-01-16 上海天伟生物制药有限公司 一种利马前列素关键中间体的制备方法
RU2648474C2 (ru) 2011-08-05 2018-03-26 Сукампо Аг Способ лечения шизофрении
CN103058907B (zh) * 2011-10-21 2016-05-11 武汉启瑞药业有限公司 鲁比前列酮或其中间体的制备方法
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
US20150057351A1 (en) 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
US20170020890A1 (en) 2015-06-19 2017-01-26 Sucampo Ag Pharmaceutical composition comprising fatty acid derivative
US10428566B2 (en) * 2017-04-17 2019-10-01 James G. Arendts Flexible unitary sandwich-like panel overhead door

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306078A (en) * 1979-12-03 1981-12-15 Hoffmann-La Roche Inc. 16-Substituted prostaglandins
US4374856A (en) 1980-09-10 1983-02-22 The Upjohn Company Liver cytoprotection using PGE's
JPS58164512A (ja) 1982-03-25 1983-09-29 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤
JPS58203911A (ja) 1982-05-25 1983-11-28 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する細肪障害治療剤
JPS62129218A (ja) 1985-12-02 1987-06-11 Teijin Ltd チアプロスタグランジン類を活性成分として含有する肝疾患治療剤
US5166174A (en) * 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
CA1323364C (en) 1987-01-28 1993-10-19 Ryuzo Ueno Prostaglandins e and anti ulcer agents containing same
JPH0688966B2 (ja) 1987-01-28 1994-11-09 株式会社アールテック・ウエノ プロスタグランジンｅ類およびそれを含む抗潰瘍剤
JPH0681728B2 (ja) 1987-10-02 1994-10-19 株式会社上野製薬応用研究所 下 剤
EP0310305B1 (en) 1987-10-02 1992-07-22 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Cathartics
JP2579193B2 (ja) 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
DD295522A5 (de) * 1989-07-26 1991-11-07 �����@������������������k�� 5-Alkyl-1,3,4-Thiadiazole, Verfahren zu ihrer Herstellung und Verwendung als Schädlingsbekämpfungsmittel
CA2027814C (en) * 1989-10-20 1996-07-30 Ryuji Ueno Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds

Also Published As

Publication number Publication date
NO308993B1 (no) 2000-11-27
CA2150287C (en) 2004-08-10
NO952214L (no) 1995-12-04
DE69511181T2 (de) 1999-12-02
GR3031066T3 (en) 1999-12-31
FI952721A0 (fi) 1995-06-02
KR960000230A (ko) 1996-01-25
CN1076605C (zh) 2001-12-26
ATE182884T1 (de) 1999-08-15
NO952214D0 (no) 1995-06-02
CA2150287A1 (en) 1995-12-04
NZ272234A (en) 1996-02-27
AU690241B2 (en) 1998-04-23
US5739161A (en) 1998-04-14
EP0690049A2 (en) 1996-01-03
EP0690049A3 (en) 1997-03-26
CN1126591A (zh) 1996-07-17
FI952721L (fi) 1995-12-04
KR100260573B1 (ko) 2000-07-01
EP0690049B1 (en) 1999-08-04
DK0690049T3 (da) 2000-03-06
FI952721A7 (fi) 1995-12-04
DE69511181D1 (de) 1999-09-09
AU2041295A (en) 1995-12-14

Similar Documents

Publication Publication Date Title
ES2137456T3 (es) Agente de tratamiento de las enfermedades hepato-biliares.
ES2123813T3 (es) Composiciones microbicidas para la desinfeccion de superficies inanimadas.
CR11037A (es) Derivados de 4-tetrazolil -4fenilpiperidina para tratar el dolor (divisional)
AR024874A1 (es) Composiciones bactericidas
DE69928672D1 (de) Pyrethrum und Benzyl Alkohol enthaltende synergistische und zurückbleibende Zusammensetzungen
ES2163736T3 (es) Composicion herbicida sinergica y metodo para el control de malas hierbas.
ES2077530B1 (es) Procedimiento para la preparacion de productos farmaceuticos para curar enfermedades tumorales.
PT750618E (pt) Derivados de oxazolidinona e composicoes farmaceuticas que os contem
AR012671A1 (es) Composiciones farmaceuticas para el tratamiento o profilaxis de la constipacion, los usos de dichas composiciones y los procesos para prepararlos
ES2188013T3 (es) Composicion biocida sinergica.
BR0313387A (pt) Composições antimicrobianas
BR0115411A (pt) Combinações sinergìsticas compreendendo um inibidor de renina para doenças cardiovasculares
ES2167436T3 (es) Tabletas de flubendazol masticables para animales de compañia.
DK1273299T3 (da) Minoxidilinindeholdende praparater
BR0209327A (pt) Composição para tratamento de constipação induzida por drogas
PY0000170A (es) 2-(hydroxyo-n-(5-nitor-2-thiazolyl) benzamide
ES2179332T3 (es) Repelentes de artropodos.
PA8542901A1 (es) Uso de (z)-2-ciano-3-hidroxi-but-2-acido enoico-(4-trifluorometilfenil)-amida para tratar la esclerosis multiple
BR0012696A (pt) Composição oftálmica
ES2136252T3 (es) Tratamiento de enfermedades causadas por trastornos de la glandula sebacea mediante el uso de inhibidores de acil coa colesterol acil transferasa.
AR021843A1 (es) Derivados de propanolamina sustituidos con heterociclos, procedimiento para su preparacion, y su utilizacion.
ES2157524T3 (es) Diselenuros y selenosulfuros utilizables como agentes antioxidantes.
ES2164340T3 (es) Agentes y procedimiento para la lucha contra los hongos dañinos.
BR9916807A (pt) Antagonistas de 5ht1 para terapia antidepressiva
MX9704490A (es) Tratamiento terapeutico combinado de las patologias hiperproliferativas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 690049

Country of ref document: ES