ZA932061B - Halichondrins - Google Patents
HalichondrinsInfo
- Publication number
- ZA932061B ZA932061B ZA932061A ZA932061A ZA932061B ZA 932061 B ZA932061 B ZA 932061B ZA 932061 A ZA932061 A ZA 932061A ZA 932061 A ZA932061 A ZA 932061A ZA 932061 B ZA932061 B ZA 932061B
- Authority
- ZA
- South Africa
- Prior art keywords
- chem
- formula
- halichondrins
- lissodendyx
- isolatable
- Prior art date
Links
- 229930195695 Halichondrin Natural products 0.000 title abstract 2
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Dental Preparations (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929206244A GB9206244D0 (en) | 1992-03-23 | 1992-03-23 | Cytotoxic compound from a marine sponge |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA932061B true ZA932061B (en) | 1993-10-19 |
Family
ID=10712627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA932061A ZA932061B (en) | 1992-03-23 | 1993-03-23 | Halichondrins |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5786492A (es) |
| EP (1) | EP0572109B1 (es) |
| JP (1) | JP3168098B2 (es) |
| AT (1) | ATE184009T1 (es) |
| AU (1) | AU671818B2 (es) |
| CA (1) | CA2092108A1 (es) |
| DE (1) | DE69326192T2 (es) |
| DK (1) | DK0572109T3 (es) |
| ES (1) | ES2138993T3 (es) |
| GB (1) | GB9206244D0 (es) |
| GR (1) | GR3031981T3 (es) |
| ZA (1) | ZA932061B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338865A (en) * | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| HU227912B1 (en) * | 1998-06-17 | 2012-05-29 | Eisai R & D Man Co | Halichondrin analogs and methods of their use and preparation |
| PL2522663T3 (pl) | 2004-06-03 | 2015-08-31 | Eisai R&D Man Co Ltd | Produkty pośrednie do otrzymywania halichondryny B |
| CN108948039B (zh) | 2007-10-03 | 2021-12-31 | 卫材R&D管理有限公司 | 用于合成软海绵素b类似物的中间体和方法 |
| CN105801599A (zh) | 2008-04-04 | 2016-07-27 | 卫材R&D管理有限公司 | 软海绵素b类似物 |
| JP2011528361A (ja) * | 2008-07-15 | 2011-11-17 | ビーエーエスエフ、カタリスツ、エルエルシー | 二酸化塩素の投与のための方法、システムおよび機器 |
| CN102803254B (zh) | 2010-01-26 | 2016-09-14 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物 |
| CN105683198B (zh) | 2013-11-04 | 2019-03-12 | 卫材R&D管理有限公司 | 软海绵素b的类似物合成中有用的大环化反应和中间体 |
| HUE043088T2 (hu) | 2013-12-06 | 2019-08-28 | Eisai R&D Man Co Ltd | Halikondrin B analógok szintézisében alkalmazható eljárások |
| EP3160970A4 (en) | 2014-06-30 | 2017-12-27 | President and Fellows of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| WO2016176560A1 (en) | 2015-04-30 | 2016-11-03 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| RU2020141025A (ru) | 2015-05-07 | 2020-12-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, полезные в синтезе макролидов галихондринов |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| KR102836514B1 (ko) | 2017-04-05 | 2025-07-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 마크로시클릭 화합물 및 그의 용도 |
| US11332480B2 (en) | 2017-04-27 | 2022-05-17 | Pharma Mar, S.A. | Antitumoral compounds |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| HUE061306T2 (hu) | 2017-07-06 | 2023-06-28 | Harvard College | Halikondrinok szintézise |
| ES2974243T3 (es) | 2017-11-15 | 2024-06-26 | Harvard College | Compuestos macrocíclicos y usos de los mismos |
| EP3713565A1 (en) | 2017-11-20 | 2020-09-30 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| KR20250057138A (ko) | 2018-01-03 | 2025-04-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물 |
-
1992
- 1992-03-23 GB GB929206244A patent/GB9206244D0/en active Pending
-
1993
- 1993-03-22 CA CA002092108A patent/CA2092108A1/en not_active Abandoned
- 1993-03-22 DK DK93302148T patent/DK0572109T3/da active
- 1993-03-22 DE DE69326192T patent/DE69326192T2/de not_active Expired - Fee Related
- 1993-03-22 AT AT93302148T patent/ATE184009T1/de not_active IP Right Cessation
- 1993-03-22 ES ES93302148T patent/ES2138993T3/es not_active Expired - Lifetime
- 1993-03-22 EP EP93302148A patent/EP0572109B1/en not_active Expired - Lifetime
- 1993-03-23 JP JP10179693A patent/JP3168098B2/ja not_active Expired - Fee Related
- 1993-03-23 AU AU35433/93A patent/AU671818B2/en not_active Ceased
- 1993-03-23 ZA ZA932061A patent/ZA932061B/xx unknown
-
1997
- 1997-07-29 US US08/902,364 patent/US5786492A/en not_active Expired - Fee Related
-
1999
- 1999-11-29 GR GR990403074T patent/GR3031981T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06122687A (ja) | 1994-05-06 |
| EP0572109A1 (en) | 1993-12-01 |
| CA2092108A1 (en) | 1993-09-24 |
| AU671818B2 (en) | 1996-09-12 |
| ATE184009T1 (de) | 1999-09-15 |
| GB9206244D0 (en) | 1992-05-06 |
| DE69326192D1 (de) | 1999-10-07 |
| JP3168098B2 (ja) | 2001-05-21 |
| US5786492A (en) | 1998-07-28 |
| EP0572109B1 (en) | 1999-09-01 |
| AU3543393A (en) | 1993-09-30 |
| DK0572109T3 (da) | 2000-03-27 |
| GR3031981T3 (en) | 2000-03-31 |
| ES2138993T3 (es) | 2000-02-01 |
| DE69326192T2 (de) | 2000-05-04 |
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