ES2141102T3 - Polipeptidos marcados con tecnecio-99m para la generacion de imagenes. - Google Patents
Polipeptidos marcados con tecnecio-99m para la generacion de imagenes.Info
- Publication number
- ES2141102T3 ES2141102T3 ES92906285T ES92906285T ES2141102T3 ES 2141102 T3 ES2141102 T3 ES 2141102T3 ES 92906285 T ES92906285 T ES 92906285T ES 92906285 T ES92906285 T ES 92906285T ES 2141102 T3 ES2141102 T3 ES 2141102T3
- Authority
- ES
- Spain
- Prior art keywords
- tecnetio
- polypeptides
- marked
- images
- generation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 229940056501 technetium 99m Drugs 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
LA INVENCION SE REFIERE A LA FORMACION DE IMAGENES RADIOMARCADAS DEL CUERPO DE UN MAMIFERO. LA INVENCION SE REFIERE, EN PARTICULAR, A REACTIVOS MARCADOS CON TECNECIO99M PARA TAL FORMACION DE IMAGENES. LA INVENCION PRESENTA PEPTIDOS QUE SE UNEN AL TECNECIO-99M Y QUE SE PUEDEN DIRIGIR A LUGARES ESPECIFICOS DENTRO DEL CUERPO DE UN MAMIFERO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65301291A | 1991-02-08 | 1991-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2141102T3 true ES2141102T3 (es) | 2000-03-16 |
Family
ID=24619134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92906285T Expired - Lifetime ES2141102T3 (es) | 1991-02-08 | 1992-02-07 | Polipeptidos marcados con tecnecio-99m para la generacion de imagenes. |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US5654272A (es) |
| EP (1) | EP0570493B1 (es) |
| JP (1) | JP2774378B2 (es) |
| KR (1) | KR930703024A (es) |
| AT (1) | ATE188387T1 (es) |
| BR (1) | BR1100906A (es) |
| CA (1) | CA2101942C (es) |
| DE (1) | DE69230525T2 (es) |
| DK (1) | DK0570493T3 (es) |
| ES (1) | ES2141102T3 (es) |
| GR (1) | GR3032851T3 (es) |
| WO (1) | WO1992013572A1 (es) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5460785A (en) * | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
| US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
| US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
| US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
| US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
| DE69230525T2 (de) * | 1991-02-08 | 2000-06-21 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5993775A (en) * | 1991-11-27 | 1999-11-30 | Diatide, Inc. | Radioactively labeled peptides comprising a single thiol moiety |
| CA2127284C (en) * | 1992-01-03 | 2002-02-05 | Buck A. Rhodes | Protein- and peptide-metal ion pharmaceutical applications |
| US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| DK0720621T3 (da) * | 1992-01-14 | 2001-08-06 | Diatide Inc | Radiomærkede somatostation-afledte peptider til billeddannende og terapeutiske anvendelser |
| WO1993017719A1 (en) * | 1992-03-13 | 1993-09-16 | Diatech, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| EP0641222B1 (en) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
| US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| US5750088A (en) | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| US6056940A (en) * | 1993-04-08 | 2000-05-02 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5464934A (en) * | 1993-05-14 | 1995-11-07 | Mallinckrodt Medical, Inc. | Metal chelates as spacer compounds in biologically active peptides |
| ES2114209T3 (es) * | 1993-07-19 | 1998-05-16 | Resolution Pharm Inc | Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s. |
| AU698176B2 (en) * | 1993-07-28 | 1998-10-29 | Cis Bio International | Radiolabelled glucans |
| US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
| JPH07149668A (ja) * | 1993-11-30 | 1995-06-13 | Kanegafuchi Chem Ind Co Ltd | アミロイド沈着検出用物質 |
| US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
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| US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
| US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
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| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
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| BRPI0210886B8 (pt) * | 2001-07-10 | 2021-05-25 | Amersham Health As | composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal |
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-
1992
- 1992-02-07 DE DE69230525T patent/DE69230525T2/de not_active Expired - Fee Related
- 1992-02-07 ES ES92906285T patent/ES2141102T3/es not_active Expired - Lifetime
- 1992-02-07 AT AT92906285T patent/ATE188387T1/de not_active IP Right Cessation
- 1992-02-07 WO PCT/US1992/000757 patent/WO1992013572A1/en not_active Ceased
- 1992-02-07 KR KR1019930702357A patent/KR930703024A/ko not_active Ceased
- 1992-02-07 CA CA002101942A patent/CA2101942C/en not_active Expired - Fee Related
- 1992-02-07 JP JP4505732A patent/JP2774378B2/ja not_active Expired - Fee Related
- 1992-02-07 DK DK92906285T patent/DK0570493T3/da active
- 1992-02-07 EP EP92906285A patent/EP0570493B1/en not_active Expired - Lifetime
-
1994
- 1994-06-22 US US08/263,758 patent/US5654272A/en not_active Expired - Lifetime
- 1994-07-11 US US08/273,274 patent/US5849260A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/464,456 patent/US5681541A/en not_active Expired - Lifetime
- 1995-06-05 US US08/463,052 patent/US5788960A/en not_active Expired - Fee Related
- 1995-06-07 US US08/478,725 patent/US5888474A/en not_active Expired - Fee Related
- 1995-06-07 US US08/475,041 patent/US5879658A/en not_active Expired - Fee Related
- 1995-06-07 US US08/480,551 patent/US5811394A/en not_active Expired - Fee Related
-
1997
- 1997-05-14 BR BR1100906-3A patent/BR1100906A/pt active IP Right Grant
-
2000
- 2000-03-03 GR GR20000400543T patent/GR3032851T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5811394A (en) | 1998-09-22 |
| DE69230525T2 (de) | 2000-06-21 |
| US5849260A (en) | 1998-12-15 |
| AU1411792A (en) | 1992-09-07 |
| US5888474A (en) | 1999-03-30 |
| US5788960A (en) | 1998-08-04 |
| KR930703024A (ko) | 1993-11-29 |
| JP2774378B2 (ja) | 1998-07-09 |
| ATE188387T1 (de) | 2000-01-15 |
| EP0570493B1 (en) | 2000-01-05 |
| CA2101942C (en) | 2001-01-30 |
| EP0570493A1 (en) | 1993-11-24 |
| US5681541A (en) | 1997-10-28 |
| BR1100906A (pt) | 2002-04-02 |
| US5879658A (en) | 1999-03-09 |
| CA2101942A1 (en) | 1992-08-09 |
| DE69230525D1 (de) | 2000-02-10 |
| GR3032851T3 (en) | 2000-07-31 |
| US5654272A (en) | 1997-08-05 |
| AU658617B2 (en) | 1995-04-27 |
| JPH06503352A (ja) | 1994-04-14 |
| DK0570493T3 (da) | 2000-06-26 |
| WO1992013572A1 (en) | 1992-08-20 |
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