ES2146007T3 - Procedimiento de recuperacion, en un caldo de fermentacion, de compuestos insolubles en agua. - Google Patents

Procedimiento de recuperacion, en un caldo de fermentacion, de compuestos insolubles en agua.

Info

Publication number
ES2146007T3
ES2146007T3 ES96923254T ES96923254T ES2146007T3 ES 2146007 T3 ES2146007 T3 ES 2146007T3 ES 96923254 T ES96923254 T ES 96923254T ES 96923254 T ES96923254 T ES 96923254T ES 2146007 T3 ES2146007 T3 ES 2146007T3
Authority
ES
Spain
Prior art keywords
water
insoluble compounds
fermentation broth
recovery procedure
recovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96923254T
Other languages
English (en)
Inventor
Alexander H T Chu
Gene P Wloch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2146007T3 publication Critical patent/ES2146007T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NUEVO PROCEDIMIENTO DE RECUPERACION DE COMPUESTOS INSOLUBLES EN AGUA, A PARTIR DE UN CALDO DE FERMENTACION, QUE INCLUYE LAS FASES SECUENCIALES DE CONCENTRAR, SOLUBILIZAR Y DIAFILTRAR EL COMPUESTO DE INTERES, TODAS A TRAVES DE UN SISTEMA CERRADO DE RECIRCULACION, A FIN DE RECUPERAR EL COMPUESTO PARA UNA PURIFICACION ULTERIOR AGUAS ABAJO.
ES96923254T 1995-06-07 1996-06-07 Procedimiento de recuperacion, en un caldo de fermentacion, de compuestos insolubles en agua. Expired - Lifetime ES2146007T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/472,615 US5616595A (en) 1995-06-07 1995-06-07 Process for recovering water insoluble compounds from a fermentation broth

Publications (1)

Publication Number Publication Date
ES2146007T3 true ES2146007T3 (es) 2000-07-16

Family

ID=23876243

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96923254T Expired - Lifetime ES2146007T3 (es) 1995-06-07 1996-06-07 Procedimiento de recuperacion, en un caldo de fermentacion, de compuestos insolubles en agua.

Country Status (11)

Country Link
US (1) US5616595A (es)
EP (1) EP0832108B1 (es)
JP (1) JP3146010B2 (es)
AT (1) ATE192162T1 (es)
CA (1) CA2222810C (es)
DE (1) DE69607961T2 (es)
DK (1) DK0832108T3 (es)
ES (1) ES2146007T3 (es)
GR (1) GR3033795T3 (es)
PT (1) PT832108E (es)
WO (1) WO1996040758A1 (es)

Families Citing this family (45)

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GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
BE1009856A5 (fr) * 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
EP0991660B8 (en) 1997-10-08 2006-04-05 Isotechnika,Inc. DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS
ID26894A (id) * 1998-04-14 2001-02-15 Dsm Nv Penyaringan membran
EP1154759B1 (en) 1998-12-30 2008-08-13 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosporin
CN1154651C (zh) 1999-05-25 2004-06-23 藤泽药品工业株式会社 分离类似的有机化合物的方法
JP3881240B2 (ja) 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 醗酵ブロスからスタチン化合物を回収するための方法
SK8312002A3 (en) * 1999-12-14 2003-05-02 Biogal Gyogyszergyar Novel forms of pravastatin sodium
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
HRP20020683A2 (en) 2000-02-24 2004-12-31 Biogal Gyogyszergyar Method of purifying a fermentation broth
DE10022258A1 (de) * 2000-05-08 2001-11-15 Bayer Ag Reinigung von Proteineinschlusskörpern durch Querstrom-Mikrofiltration
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
FR2821347A1 (fr) * 2001-02-23 2002-08-30 Vanlaer Fluides Et Automation Systeme de traitement de solution aqueuse par membrane et fermentation
BR0209036A (pt) * 2001-04-18 2007-01-02 Buddy Don Gray método e aparelho para um sistema de separação tangencial recirculante
US7141648B2 (en) 2001-10-19 2006-11-28 Isotechnika Inc. Synthesis of cyclosporin analogs
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
MXPA04007847A (es) * 2002-02-13 2005-02-24 Biogal Gyogyszergyar Metodo para extraer un macrolido de biomateria.
US8685428B2 (en) * 2002-12-10 2014-04-01 Advanced Cardiovascular Systems, Inc. Therapeutic composition and a method of coating implantable medical devices
EP1603512A2 (en) 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Novel cyclosporins
WO2005019226A1 (en) * 2003-08-26 2005-03-03 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
CA2546377A1 (en) * 2003-11-24 2005-06-09 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying pravastatin
RU2317991C1 (ru) * 2003-12-05 2008-02-27 Байокон Лимитид Способ выделения и очистки макролидов
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
WO2006039164A2 (en) 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
WO2006039588A2 (en) * 2004-09-30 2006-04-13 Bayer Healthcare Llc Devices and methods for integrated continuous manufacturing of biological molecules
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
WO2006069333A1 (en) * 2004-12-22 2006-06-29 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Method of purifying macrolides
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
TW200640854A (en) * 2005-02-09 2006-12-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods of making pravastatin sodium
JP4700022B2 (ja) * 2006-03-15 2011-06-15 アイバックス ファーマシューティカルズ スポレツノスト エス ルチェニム オメゼニム タクロリマスの精製方法
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
KR101101663B1 (ko) * 2009-01-13 2011-12-30 (주) 제노텍 반코마이신 습체의 정제방법
WO2014072984A1 (en) 2012-11-06 2014-05-15 Natco Pharma Limited Improved process for isolation and purification of rapamycin from fermentation broth
US10183108B2 (en) 2016-02-04 2019-01-22 Pall Corporation Inline diafiltration with multi-channel pump
BR112021000617A2 (pt) 2018-07-27 2021-04-06 Arc Medical Devices Inc. Fucanos com elevado teor de sulfato para o tratamento de aderências fibrosas
US12186334B2 (en) 2018-07-27 2025-01-07 ARC Medical Inc. High-molecular-weight fucans for treating fibrous adhesions and other diseases and conditions
MX2021000866A (es) 2019-03-05 2021-06-15 Arc Medical Devices Inc Sistemas y metodos para la filtracion de flujo tangencial de composiciones viscosas.
AU2020307169A1 (en) * 2019-06-28 2022-02-24 Grafoid Inc. Graphene based filters and systems comprising same
US11806667B2 (en) 2021-04-05 2023-11-07 Government Of The United States, As Represented By The Secretary Of The Army Portable membrane filtration
CN113325108B (zh) * 2021-06-04 2022-12-09 山东霆科药业有限公司 一种他克莫司软膏的样品前处理方法
EP4380772A4 (en) * 2021-08-03 2025-05-21 Pyrowave Inc. Method and system for extracting contaminants from waste polymers
CN113603731B (zh) * 2021-09-14 2024-02-06 陕西麦可罗生物科技有限公司 一种中生菌素分离方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法
CN115025611B (zh) * 2022-07-12 2024-03-29 景德镇富祥生命科技有限公司 一种有效去除子囊霉素发酵尾气异味的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.

Also Published As

Publication number Publication date
GR3033795T3 (en) 2000-10-31
DE69607961T2 (de) 2000-12-07
JPH10511000A (ja) 1998-10-27
CA2222810A1 (en) 1996-12-19
EP0832108A1 (en) 1998-04-01
CA2222810C (en) 2002-02-12
DK0832108T3 (da) 2000-09-25
WO1996040758A1 (en) 1996-12-19
PT832108E (pt) 2000-08-31
EP0832108B1 (en) 2000-04-26
DE69607961D1 (de) 2000-05-31
US5616595A (en) 1997-04-01
ATE192162T1 (de) 2000-05-15
JP3146010B2 (ja) 2001-03-12

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