DK0832108T3 - Fremgangsmåde til udvinding af vanduopløselige forbindelser fra et fermentationsmedium - Google Patents

Fremgangsmåde til udvinding af vanduopløselige forbindelser fra et fermentationsmedium

Info

Publication number
DK0832108T3
DK0832108T3 DK96923254T DK96923254T DK0832108T3 DK 0832108 T3 DK0832108 T3 DK 0832108T3 DK 96923254 T DK96923254 T DK 96923254T DK 96923254 T DK96923254 T DK 96923254T DK 0832108 T3 DK0832108 T3 DK 0832108T3
Authority
DK
Denmark
Prior art keywords
insoluble compounds
recovering water
fermentation medium
compound
recovering
Prior art date
Application number
DK96923254T
Other languages
English (en)
Inventor
Alexander H T Chu
Gene P Wloch
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK0832108T3 publication Critical patent/DK0832108T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK96923254T 1995-06-07 1996-06-07 Fremgangsmåde til udvinding af vanduopløselige forbindelser fra et fermentationsmedium DK0832108T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/472,615 US5616595A (en) 1995-06-07 1995-06-07 Process for recovering water insoluble compounds from a fermentation broth
PCT/US1996/009787 WO1996040758A1 (en) 1995-06-07 1996-06-07 Process for recovering water-insoluble compounds from a fermentation broth

Publications (1)

Publication Number Publication Date
DK0832108T3 true DK0832108T3 (da) 2000-09-25

Family

ID=23876243

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96923254T DK0832108T3 (da) 1995-06-07 1996-06-07 Fremgangsmåde til udvinding af vanduopløselige forbindelser fra et fermentationsmedium

Country Status (11)

Country Link
US (1) US5616595A (da)
EP (1) EP0832108B1 (da)
JP (1) JP3146010B2 (da)
AT (1) ATE192162T1 (da)
CA (1) CA2222810C (da)
DE (1) DE69607961T2 (da)
DK (1) DK0832108T3 (da)
ES (1) ES2146007T3 (da)
GR (1) GR3033795T3 (da)
PT (1) PT832108E (da)
WO (1) WO1996040758A1 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
FR2736550B1 (fr) * 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
DE69832984T2 (de) 1997-10-08 2006-09-21 Isotechnika, Inc., Edmonton DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
EP1071744B1 (en) * 1998-04-14 2003-06-25 Dsm N.V. Membrane filtration
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
PT1183261E (pt) * 1999-05-25 2004-11-30 Fujisawa Pharmaceutical Co Metodo para separar compostos organicos analogos
WO2001039768A1 (en) 1999-11-30 2001-06-07 Biogal Gyogyszergyar Rt Process for recovering statin compounds from a fermentation broth
HK1049441A1 (zh) * 1999-12-14 2003-05-16 Biogal Gyogyszergyar Rt 普伐他丁钠的崭新形式
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
WO2001062949A1 (en) 2000-02-24 2001-08-30 Biogal Gyogyszergyar Rt Method of purifying a fermentation broth
DE10022258A1 (de) * 2000-05-08 2001-11-15 Bayer Ag Reinigung von Proteineinschlusskörpern durch Querstrom-Mikrofiltration
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
FR2821347A1 (fr) * 2001-02-23 2002-08-30 Vanlaer Fluides Et Automation Systeme de traitement de solution aqueuse par membrane et fermentation
KR20040020053A (ko) * 2001-04-18 2004-03-06 버디 돈 그레이 재순환 탄젠셜 분리 시스템을 위한 장치 및 방법
HRP20070058B1 (hr) 2001-10-19 2014-05-23 Isotechnika Inc. Sinteza ciklosporinskih analoga
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
EP1474404A4 (en) * 2002-02-13 2006-01-11 Biogal Gyogyszergyar PROCESS FOR EXTRACTION OF A BIOLOGICAL MATERIAL
US8685428B2 (en) * 2002-12-10 2014-04-01 Advanced Cardiovascular Systems, Inc. Therapeutic composition and a method of coating implantable medical devices
CA2518265A1 (en) 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
PL1641447T3 (pl) 2003-11-24 2009-04-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania prawastatyny
CA2548297C (en) * 2003-12-05 2011-06-14 Biocon Limited Process for the purification of macrolides
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008514702A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
CN102794109B (zh) * 2004-09-30 2015-10-07 拜耳医药保健有限公司 用于集成连续生产生物分子的装置和方法
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
TW200637835A (en) * 2004-12-22 2006-11-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying tacrolimus
WO2006083486A1 (en) * 2005-01-05 2006-08-10 TEVA GYÓGYSZERGYÁR ZÁRTKöR..EN M..k..D.. RÉSZVÉNYTÁRSASÁG Amorphous tacrolimus and preparation thereof
CN101115706A (zh) * 2005-02-09 2008-01-30 特瓦药厂私人有限公司 制备普伐他汀钠的方法
US20080000834A1 (en) * 2006-03-15 2008-01-03 Ladislav Cvak Process for purifying Tacrolimus
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
KR101101663B1 (ko) * 2009-01-13 2011-12-30 (주) 제노텍 반코마이신 습체의 정제방법
WO2014072984A1 (en) 2012-11-06 2014-05-15 Natco Pharma Limited Improved process for isolation and purification of rapamycin from fermentation broth
US10183108B2 (en) 2016-02-04 2019-01-22 Pall Corporation Inline diafiltration with multi-channel pump
MX2021000864A (es) 2018-07-27 2021-03-26 Arc Medical Devices Inc Fucanos altos en sulfato para el tratamiento de adhesiones fibrosas.
US12186334B2 (en) 2018-07-27 2025-01-07 ARC Medical Inc. High-molecular-weight fucans for treating fibrous adhesions and other diseases and conditions
AU2020230466B2 (en) * 2019-03-05 2021-05-13 Arc Medical Devices Inc. Systems and methods for tangential flow filtration of viscous compositions
AU2020307169A1 (en) * 2019-06-28 2022-02-24 Grafoid Inc. Graphene based filters and systems comprising same
US11806667B2 (en) 2021-04-05 2023-11-07 Government Of The United States, As Represented By The Secretary Of The Army Portable membrane filtration
CN113325108B (zh) * 2021-06-04 2022-12-09 山东霆科药业有限公司 一种他克莫司软膏的样品前处理方法
US20240287274A1 (en) * 2021-08-03 2024-08-29 Pyrowave Inc. Method and system for extracting contaminants from waste polymers
CN113603731B (zh) * 2021-09-14 2024-02-06 陕西麦可罗生物科技有限公司 一种中生菌素分离方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法
CN115025611B (zh) * 2022-07-12 2024-03-29 景德镇富祥生命科技有限公司 一种有效去除子囊霉素发酵尾气异味的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.

Also Published As

Publication number Publication date
DE69607961D1 (de) 2000-05-31
JPH10511000A (ja) 1998-10-27
PT832108E (pt) 2000-08-31
JP3146010B2 (ja) 2001-03-12
ES2146007T3 (es) 2000-07-16
DE69607961T2 (de) 2000-12-07
ATE192162T1 (de) 2000-05-15
GR3033795T3 (en) 2000-10-31
US5616595A (en) 1997-04-01
EP0832108A1 (en) 1998-04-01
WO1996040758A1 (en) 1996-12-19
CA2222810A1 (en) 1996-12-19
EP0832108B1 (en) 2000-04-26
CA2222810C (en) 2002-02-12

Similar Documents

Publication Publication Date Title
GR3033795T3 (en) Process for recovering water-insoluble compounds from a fermentation broth
GB1528316A (en) Purifying xanthan gum
PT828717E (pt) Metodo de preparacao de 3-haloalquil-1h-pirazoles
DE3752362D1 (de) Optisch aktive Verbindungen
AU6831096A (en) Quiescent cell populations for nuclear transfer
CA2254871A1 (en) Purification of biologically active peptides from milk
DK0759031T3 (da) Forbedret fremgangsmåde til fremstilling af en forbindelse afledt af aspartam som er anvendelig som sødemiddel
DK0592434T3 (da) Forbedret fremgangsmåde til syntese af oligomerer
DK0894091T3 (da) Fremgangsmåde til oprensning af et protein fra en proteinholdig opløsning
FI931274A0 (fi) Menetelmä puhdistettujen glykolipidien valmistamiseksi käyttäen membraanierotusmenetelmää
EA199600019A2 (ru) Способ получения метилтиогидроксибутиронитрила
DK1060134T3 (da) Fremgangsmåde og indretning til behandling af vandige strømme i en bioreaktor, en ultrafiltreringsenhed og en membranfiltreringsenhed
ATE239091T1 (de) Natamycin gewinnung
EP0816374A3 (en) A method of preparing a composition containing a high proportion of ganglioside
DK0719279T3 (da) Fremgangsmåde til rensning af 1-[N2-((S)-ethoxycarbonyl)-3-phenylpropyl)-N6-trifluoracetyl]-L-lysyl-L-prolin (lisinopril(Tf
CA2187210A1 (en) Method for purifying diacetylrhein
DK0784605T3 (da) Selektiv fremgangsmåde til deacyleringen af acylforbindelser
ES2112042T3 (es) Procedimiento para la recuperacion de natamicina.
MX9709740A (es) Proceso para recuperar compuestos insolubles en agua de un caldo de fermentacion.
DK0552191T3 (da) Mikroorganisme og fremgangsmåde til udvinding af anthranilsyre
AU1263799A (en) A method for purifying water, in particular ground water, under anaerobic conditions, using a membrane filtration unit, a device for purifying water, as well asdrinking water obtained by using such a method
DK1007647T3 (da) Höjniveauekspression af INGAP
GB9325804D0 (en) An aid to recovery from disease caused by bacteria,viruses and malignant cells
GR930100408A (el) Μέ?οδος απομόνωσης και κα?αρισμού μεβινολίνης.
ATE202146T1 (de) Verbesserte enzymatische kupplungsreaktion von n- geschützte l-asparaginsäure und phenylalaninmethylester