ATE192162T1 - Verfahren zür rückgewinnung wasser-unlöslicher verbindungen aus einer fermentations brühe - Google Patents

Verfahren zür rückgewinnung wasser-unlöslicher verbindungen aus einer fermentations brühe

Info

Publication number
ATE192162T1
ATE192162T1 AT96923254T AT96923254T ATE192162T1 AT E192162 T1 ATE192162 T1 AT E192162T1 AT 96923254 T AT96923254 T AT 96923254T AT 96923254 T AT96923254 T AT 96923254T AT E192162 T1 ATE192162 T1 AT E192162T1
Authority
AT
Austria
Prior art keywords
fermentation broth
insoluble compounds
recovering water
compound
recovering
Prior art date
Application number
AT96923254T
Other languages
English (en)
Inventor
Alexander H T Chu
Gene P Wloch
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE192162T1 publication Critical patent/ATE192162T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT96923254T 1995-06-07 1996-06-07 Verfahren zür rückgewinnung wasser-unlöslicher verbindungen aus einer fermentations brühe ATE192162T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/472,615 US5616595A (en) 1995-06-07 1995-06-07 Process for recovering water insoluble compounds from a fermentation broth
PCT/US1996/009787 WO1996040758A1 (en) 1995-06-07 1996-06-07 Process for recovering water-insoluble compounds from a fermentation broth

Publications (1)

Publication Number Publication Date
ATE192162T1 true ATE192162T1 (de) 2000-05-15

Family

ID=23876243

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96923254T ATE192162T1 (de) 1995-06-07 1996-06-07 Verfahren zür rückgewinnung wasser-unlöslicher verbindungen aus einer fermentations brühe

Country Status (11)

Country Link
US (1) US5616595A (de)
EP (1) EP0832108B1 (de)
JP (1) JP3146010B2 (de)
AT (1) ATE192162T1 (de)
CA (1) CA2222810C (de)
DE (1) DE69607961T2 (de)
DK (1) DK0832108T3 (de)
ES (1) ES2146007T3 (de)
GR (1) GR3033795T3 (de)
PT (1) PT832108E (de)
WO (1) WO1996040758A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
FR2736550B1 (fr) * 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ATE314388T1 (de) 1997-10-08 2006-01-15 Isotechnika Inc Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien
SI1071744T1 (en) * 1998-04-14 2003-12-31 Dsm Ip Assets B.V. Membrane filtration
PT1154759E (pt) 1998-12-30 2008-11-20 Dexcel Ltd Concentrado dispersível para administração de ciclosporina
RU2234509C2 (ru) * 1999-05-25 2004-08-20 Фудзисава Фармасьютикал Ко., Лтд. Способ разделения подобных органических соединений
MXPA02005283A (es) 1999-11-30 2003-10-06 Biogal Gyogyszergyar Proceso para recuperar compuestos estatina de un caldo de fermentacion.
CZ20021998A3 (cs) * 1999-12-14 2003-02-12 Biogal Gyogyszergyar Rt. Nové formy sodné soli pravastatinu
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2001236543B2 (en) 2000-02-24 2005-02-03 Teva Gyogyszergyar Reszvenytarsasag Method of purifying a fermentation broth
DE10022258A1 (de) * 2000-05-08 2001-11-15 Bayer Ag Reinigung von Proteineinschlusskörpern durch Querstrom-Mikrofiltration
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
FR2821347A1 (fr) * 2001-02-23 2002-08-30 Vanlaer Fluides Et Automation Systeme de traitement de solution aqueuse par membrane et fermentation
KR20040020053A (ko) * 2001-04-18 2004-03-06 버디 돈 그레이 재순환 탄젠셜 분리 시스템을 위한 장치 및 방법
BRPI0213658A8 (pt) 2001-10-19 2016-12-06 F Hoffmann La Roche Ltd Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
MXPA04007847A (es) * 2002-02-13 2005-02-24 Biogal Gyogyszergyar Metodo para extraer un macrolido de biomateria.
US8685428B2 (en) * 2002-12-10 2014-04-01 Advanced Cardiovascular Systems, Inc. Therapeutic composition and a method of coating implantable medical devices
EP1603512A2 (de) 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Neue cyclosporine
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
PL1641447T3 (pl) 2003-11-24 2009-04-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania prawastatyny
EP1697383B1 (de) * 2003-12-05 2014-04-23 Biocon Limited Verfahren zur aufreinigung von tacrolimus
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
LT2550971T (lt) * 2004-09-30 2018-10-25 Bayer Healthcare Llc Biologinių molekulių integruotos nepertraukiamos gamybos aparatai ir būdai
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
EP1828204A1 (de) * 2004-12-22 2007-09-05 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Verfahren zur aufreinigung von makroliden
TW200635934A (en) * 2005-01-05 2006-10-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Amorphous tacrolimus and preparation thereof
CN101115706A (zh) * 2005-02-09 2008-01-30 特瓦药厂私人有限公司 制备普伐他汀钠的方法
TW200815458A (en) * 2006-03-15 2008-04-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for purifying Tacrolimus
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
KR101101663B1 (ko) * 2009-01-13 2011-12-30 (주) 제노텍 반코마이신 습체의 정제방법
WO2014072984A1 (en) 2012-11-06 2014-05-15 Natco Pharma Limited Improved process for isolation and purification of rapamycin from fermentation broth
US10183108B2 (en) 2016-02-04 2019-01-22 Pall Corporation Inline diafiltration with multi-channel pump
US12186334B2 (en) 2018-07-27 2025-01-07 ARC Medical Inc. High-molecular-weight fucans for treating fibrous adhesions and other diseases and conditions
BR112021000631A2 (pt) 2018-07-27 2021-04-06 Arc Medical Devices Inc. Composições, sistemas e métodos com baixo teor de endotoxina
RU2768923C1 (ru) * 2019-03-05 2022-03-25 ЭйАрСи МЕДИКАЛ ДИВАЙСИЗ ИНК. Система для тангенциально-поточного фильтрования вязких композиций
AU2020307169A1 (en) * 2019-06-28 2022-02-24 Grafoid Inc. Graphene based filters and systems comprising same
US11806667B2 (en) 2021-04-05 2023-11-07 Government Of The United States, As Represented By The Secretary Of The Army Portable membrane filtration
CN113325108B (zh) * 2021-06-04 2022-12-09 山东霆科药业有限公司 一种他克莫司软膏的样品前处理方法
EP4380772A4 (de) * 2021-08-03 2025-05-21 Pyrowave Inc. Verfahren und system zur extraktion von verunreinigungen aus polymeren abfallstoffen
CN113603731B (zh) * 2021-09-14 2024-02-06 陕西麦可罗生物科技有限公司 一种中生菌素分离方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法
CN115025611B (zh) * 2022-07-12 2024-03-29 景德镇富祥生命科技有限公司 一种有效去除子囊霉素发酵尾气异味的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
EP0507968B1 (de) * 1991-04-06 1995-09-06 Arzneimittelwerk Dresden Gmbh Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme

Also Published As

Publication number Publication date
PT832108E (pt) 2000-08-31
DK0832108T3 (da) 2000-09-25
DE69607961D1 (de) 2000-05-31
US5616595A (en) 1997-04-01
CA2222810C (en) 2002-02-12
GR3033795T3 (en) 2000-10-31
CA2222810A1 (en) 1996-12-19
DE69607961T2 (de) 2000-12-07
EP0832108A1 (de) 1998-04-01
JP3146010B2 (ja) 2001-03-12
ES2146007T3 (es) 2000-07-16
WO1996040758A1 (en) 1996-12-19
JPH10511000A (ja) 1998-10-27
EP0832108B1 (de) 2000-04-26

Similar Documents

Publication Publication Date Title
ATE192162T1 (de) Verfahren zür rückgewinnung wasser-unlöslicher verbindungen aus einer fermentations brühe
PT828717E (pt) Metodo de preparacao de 3-haloalquil-1h-pirazoles
DK0606921T3 (da) Fremgangsmåde til isolering af Haemophilus influenzae protein E
ATE240348T1 (de) Verfahren zur herstellung eines proteins
ATE296885T1 (de) Verfahren für die produktion von peptiden unter verwendung eines in vitro transkription/translation system
DE69131775D1 (de) Verfahren zur Herstellung wasserlöslicher Camptothecinanaloge, sowie die Verbindungen 10-Hydroxy-11-C(1-6)-alkoxycamptothecin
ATE138923T1 (de) Verfahren zur herstellung gereinigter glycolipide durch membrantrennverfahren
ATE231150T1 (de) Optisch aktive verbindungen
CA2393057A1 (en) Process for recovering pravastatin from a fermentation broth
ATE481378T1 (de) Verfahren zur herstellung von 1-alkoxycarbonyl-3- phenylpropylderivaten
DK0894091T3 (da) Fremgangsmåde til oprensning af et protein fra en proteinholdig opløsning
EA199600019A3 (ru) Способ получения метилтиогидроксибутиронитрила
Barbas et al. Papain catalysed peptide synthesis: control of amidase activity and the introduction of unusual amino acids
AU6520896A (en) Method for production of oligomethyleneurea
CA2187210A1 (en) Method for purifying diacetylrhein
DK0754239T3 (da) Fremgangsmåde til indvinding af natamycin
DE69826852T8 (de) Verbessertes verfahren zur fermentativen herstellung von penicillin
EP1336603A4 (de) Verfahren zur einführung von aminogruppen und verfahren zur synthese von aminosäuren
DK0784605T3 (da) Selektiv fremgangsmåde til deacyleringen af acylforbindelser
ATA189096A (de) Verfahren zur reinigung von o-phthaldialdehyd
MX9709740A (es) Proceso para recuperar compuestos insolubles en agua de un caldo de fermentacion.
EP0375333A3 (de) Methode zum reduktiven Methylieren von primären Aminen
AU1263799A (en) A method for purifying water, in particular ground water, under anaerobic conditions, using a membrane filtration unit, a device for purifying water, as well asdrinking water obtained by using such a method
ATE323760T1 (de) Verfahren zur herstellung eines eine hyaluronidase enthaltenden präparats
Fabre et al. Enzymatic synthesis of amino acid ester of butyl α-D-glucopyranoside

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification