ES2182900T3 - Extractos de cartilago de tiburon, que tienen una actividad anti-angiogenica y efecto en regresion de tumor, proceso para su produccion. - Google Patents

Extractos de cartilago de tiburon, que tienen una actividad anti-angiogenica y efecto en regresion de tumor, proceso para su produccion.

Info

Publication number
ES2182900T3
ES2182900T3 ES95916523T ES95916523T ES2182900T3 ES 2182900 T3 ES2182900 T3 ES 2182900T3 ES 95916523 T ES95916523 T ES 95916523T ES 95916523 T ES95916523 T ES 95916523T ES 2182900 T3 ES2182900 T3 ES 2182900T3
Authority
ES
Spain
Prior art keywords
activity
cartilago
extracts
superior
bolita
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95916523T
Other languages
English (en)
Inventor
Eric Dupont
Paul Brazeau
Christina Juneau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cosciens Biopharma Inc
Original Assignee
Les Laboratories Aeterna Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratories Aeterna Inc filed Critical Les Laboratories Aeterna Inc
Application granted granted Critical
Publication of ES2182900T3 publication Critical patent/ES2182900T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A EXTRACTOS DE CARTILAGO DE TIBURON Y A UN METODO PARA PRODUCIRLOS, ESTOS EXTRACTOS TIENEN PROPIEDADES ANTIANGIOGENICAS (SE HA OBSERVADO IN VIVO LA REDUCCION DEL AREA DE VASOS SANGUINEOS EN TUMORES INDUCIDOS EXPERIMENTALMENTE), ACTIVIDAD REGRESIVA DEL TUMOR IN VIVO ASI COMO DEMUESTRAN UN EFECTO INHIBITORIO DIRECTO EN LAS LINEAS CELULARES DEL TUMOR. ESTE PROCESO NO NECESITA DE NINGUN PRODUCTO O SOLVENTE DESNATURALIZADOR NI EL USO DE NINGUNA ENZIMA. CONSISTE EN OBTENER UNA MEZCLA DEL CONJUNTO DEL CARTILAGO EN UNA SOLUCION ACUOSA DE PH NEUTRAL, PREFERIBLEMENTE AGUA PURA, ESTA MEZCLA ES CENTRIFUGADA GUARDANDOSE LA BOLITA Y EL SOBRENADANTE PARA UN PROCESAMIENTO POSTERIOR. LA BOLITA SE LIOFILIZA Y PRUEBA EN LAS ACTIVIDADES ANTITUMORALES Y ANTIANGIOGENICA IN VIVO E IN VITRO, CON O SIN SOBRENADANTE. EL SOBRENADANTE HA DEMOSTRADO TENER IN VIVO ACTIVIDAD ANGIOGENICA Y DE REGRESION TUMORAL. LA COMPOSICION DEL SOBRENADANTE SE HA INVESTIGADO DE DIFERENTES FORMAS. EL FRACCIONAMIENTO DE ESTE SOBRENADANTE PERMITIO LA CARACTERIZACION DE ALGUNOS DE SUS COMPONENTES ACTIVOS. LA ACTIVIDAD DIRECTA IN VIVO DE LAS FRACCIONES HA SIDO PROBADA EN LAS LINEAS CELULARES TUMORALES. ADEMAS SE ASUME QUE EL SOBRENADANTE NO FRACCIONADO TIENE LA MISMA ACTIVIDAD IN VITRO. LA LIOFILIZACION DESTRUYE SUSTANCIALMENTE LA ACTIVIDAD DE ESTAS FRACCIONES LIQUIDAS SIN QUE SE HAYA OBSERVADO ESTA DESTRUCCION EN EL EXTRACTO SOLIDO.
ES95916523T 1994-04-28 1995-04-21 Extractos de cartilago de tiburon, que tienen una actividad anti-angiogenica y efecto en regresion de tumor, proceso para su produccion. Expired - Lifetime ES2182900T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23401994A 1994-04-28 1994-04-28
US08/384,555 US5618925A (en) 1994-04-28 1995-02-03 Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof

Publications (1)

Publication Number Publication Date
ES2182900T3 true ES2182900T3 (es) 2003-03-16

Family

ID=26927471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95916523T Expired - Lifetime ES2182900T3 (es) 1994-04-28 1995-04-21 Extractos de cartilago de tiburon, que tienen una actividad anti-angiogenica y efecto en regresion de tumor, proceso para su produccion.

Country Status (24)

Country Link
US (2) US5618925A (es)
EP (1) EP0759765B1 (es)
JP (1) JPH09512563A (es)
KR (1) KR100378787B1 (es)
CN (2) CN1541656A (es)
AT (1) ATE224198T1 (es)
BG (1) BG62954B1 (es)
BR (1) BR9507552A (es)
CA (1) CA2188793C (es)
CZ (1) CZ290520B6 (es)
DE (1) DE69528258T2 (es)
DK (1) DK0759765T3 (es)
ES (1) ES2182900T3 (es)
FI (1) FI117375B (es)
HU (1) HU220784B1 (es)
IS (1) IS1975B (es)
NO (1) NO317674B1 (es)
NZ (1) NZ284407A (es)
PL (1) PL181981B1 (es)
PT (1) PT759765E (es)
RO (1) RO114868B1 (es)
RU (1) RU2156132C2 (es)
SI (1) SI0759765T1 (es)
WO (1) WO1995032722A1 (es)

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US5618925A (en) * 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
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RU2157695C2 (ru) * 1995-02-03 2000-10-20 Ле Лабораториз Аетерна Инк. Экстракты хрящей акулы, способ их получения и применения
US5843920A (en) * 1996-09-16 1998-12-01 Biocell Technology, Llc Anionic saccharides for extraction of anti-angiogenic protein from cartilage
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ATE241993T1 (de) * 1997-03-11 2003-06-15 Aeterna Lab Inc Zubereitungen zur tumorbehandlung enthaltend hai- knorpelextrakte und antineoplastische mittel
CA2295519C (en) * 1997-07-11 2008-12-16 Cv Technologies Inc. A preparation derived from shark cartilage for treatment of diseases related to excessive phf or excessive intracellular calcium
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AU771224B2 (en) 1998-07-13 2004-03-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US6168807B1 (en) 1998-07-23 2001-01-02 Les Laboratoires Aeterna Inc. Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
US20020009501A1 (en) * 1998-07-23 2002-01-24 Eric Dupont Preparation of cartilage extracts using organic solvents
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US20030087830A1 (en) * 2001-06-12 2003-05-08 Eric Dupont Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof
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US6908627B2 (en) * 2001-06-21 2005-06-21 Mote Marine Laboratory Conditioned media for inhibiting growth of tumor cells
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US7572442B2 (en) 2002-07-15 2009-08-11 Board Of Regents, The University Of Texas System Selected antibody compositions for binding to aminophospholipids
US20070010430A1 (en) * 2003-03-20 2007-01-11 Hosokawa Micron Corparation Proteoglycan isolated from cartilaginous fish and process for producing the same
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Also Published As

Publication number Publication date
HU220784B1 (hu) 2002-05-28
DK0759765T3 (da) 2003-01-27
JPH09512563A (ja) 1997-12-16
AU719118B2 (en) 2000-05-04
PT759765E (pt) 2003-02-28
RU2156132C2 (ru) 2000-09-20
NO317674B1 (no) 2004-11-29
US5618925A (en) 1997-04-08
IS4379A (is) 1996-10-25
CZ314196A3 (en) 1997-04-16
CN1147305C (zh) 2004-04-28
BG100941A (en) 1997-07-31
PL181981B1 (en) 2001-10-31
NO964547L (no) 1996-12-30
HU9602975D0 (en) 1997-01-28
HUT76554A (en) 1997-09-29
NZ284407A (en) 1998-04-27
CA2188793C (en) 2001-01-16
WO1995032722A1 (en) 1995-12-07
KR100378787B1 (ko) 2003-06-19
DE69528258D1 (de) 2002-10-24
IS1975B (is) 2005-01-14
BG62954B1 (bg) 2000-12-29
FI964327A7 (fi) 1996-12-20
RO114868B1 (ro) 1999-08-30
CZ290520B6 (cs) 2002-08-14
BR9507552A (pt) 1997-08-05
KR970702729A (ko) 1997-06-10
ATE224198T1 (de) 2002-10-15
CA2188793A1 (en) 1995-12-07
CN1541656A (zh) 2004-11-03
PL317076A1 (en) 1997-03-03
CN1153477A (zh) 1997-07-02
SI0759765T1 (en) 2003-02-28
FI117375B (fi) 2006-09-29
FI964327A0 (fi) 1996-10-28
DE69528258T2 (de) 2003-04-17
NO964547D0 (no) 1996-10-25
EP0759765A1 (en) 1997-03-05
US5985839A (en) 1999-11-16
EP0759765B1 (en) 2002-09-18
AU2300195A (en) 1995-12-21

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