ES2148283T3 - Gen merlin supresor de tumores y usos del mismo. - Google Patents

Gen merlin supresor de tumores y usos del mismo.

Info

Publication number
ES2148283T3
ES2148283T3 ES94301367T ES94301367T ES2148283T3 ES 2148283 T3 ES2148283 T3 ES 2148283T3 ES 94301367 T ES94301367 T ES 94301367T ES 94301367 T ES94301367 T ES 94301367T ES 2148283 T3 ES2148283 T3 ES 2148283T3
Authority
ES
Spain
Prior art keywords
merlin
gen
same
tumor suppressor
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94301367T
Other languages
English (en)
Inventor
James A Trofatter
Mia M Maccollin
James F Gusella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Application granted granted Critical
Publication of ES2148283T3 publication Critical patent/ES2148283T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DESCRIBE UNA NUEVA PROTEINA SUPRESORA DE TUMORES, MERLIN , QUE COMPRENDE SECUENCIAS DE ADN QUE CODIFICAN MERLIN, VECTORES RECOMBINANTES Y HUESPEDES CAPACES DE EXPRESAR MERLIN. SE PREVEN TAMBIEN EL METODO PARA EL DIAGNOSTICO Y TRATAMIENTO DE TUMORES ASOCIADOS A MERLIN, Y PARA EL DIAGNOSTICO Y TRATAMIENTO DE LA ENFERMEDAD NEUROFIBROMATOSIS 2(NF2).
ES94301367T 1993-02-25 1994-02-25 Gen merlin supresor de tumores y usos del mismo. Expired - Lifetime ES2148283T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2203493A 1993-02-25 1993-02-25
US2606393A 1993-03-04 1993-03-04
US10880893A 1993-08-19 1993-08-19
US08/171,718 US5707863A (en) 1993-02-25 1993-12-22 Tumor suppressor gene merlin

Publications (1)

Publication Number Publication Date
ES2148283T3 true ES2148283T3 (es) 2000-10-16

Family

ID=27487063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94301367T Expired - Lifetime ES2148283T3 (es) 1993-02-25 1994-02-25 Gen merlin supresor de tumores y usos del mismo.

Country Status (10)

Country Link
US (2) US5707863A (es)
EP (1) EP0613945B1 (es)
JP (1) JPH07143884A (es)
AT (1) ATE192489T1 (es)
CA (1) CA2115404A1 (es)
DE (1) DE69424209T2 (es)
DK (1) DK0613945T3 (es)
ES (1) ES2148283T3 (es)
GR (1) GR3034057T3 (es)
PT (1) PT613945E (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578462A (en) * 1994-01-10 1996-11-26 Bristol-Myers Squibb Company NF2 isoforms
AU2456397A (en) * 1996-04-12 1997-11-07 Muro Pharmaceutical, Inc. Isolated and cloned mast cell 78 kda phosphoprotein (mast cell degranulation inhibitory agent) and use thereof
GB9812674D0 (en) * 1998-06-12 1998-08-12 Central Manchester Healthcare Nucleic acids
US7053200B1 (en) 1999-06-01 2006-05-30 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
DK1471926T3 (da) 1999-06-01 2011-02-28 Baylor College Medicine Sammensætninger og fremgangsmåder til terapeutisk anvendelse af en atonal-associeret sekvens
AU6181300A (en) * 1999-07-29 2001-02-19 Helix Research Institute Liver cancer-associated genes
AU2953201A (en) * 2000-01-20 2001-07-31 Genome Therapeutics Corporation Rapid determination of gene structure using cdna sequence
ES2291246T3 (es) * 2000-06-27 2008-03-01 Von Recklinghausen Gesellschaft E.V. Procedimiento para adquirir datos para el diagnostico presintomatico o prenatal de neurofribromatosis del tipo 1.
US20040014699A1 (en) * 2002-07-18 2004-01-22 Isis Pharmaceuticals, Inc. Antisense modulation of PTPRM expression
US20040249023A1 (en) * 2003-01-17 2004-12-09 Stoffer James O. Compounds for corrosion resistant primer coatings and protection of metal substrates
CA2862580A1 (en) * 2011-10-28 2013-05-02 Millennium Pharmaceuticals, Inc. Biomarkers of response to nae inhibitors
TWI710635B (zh) 2014-10-09 2020-11-21 美商珍維克公司 編碼人類無調同源物-1(hath1)之腺病毒載體
CN110846309B (zh) * 2018-08-20 2023-03-24 中国农业科学院兰州兽医研究所 用于鉴定多房棘球绦虫引物对、引物探针组以及他们的应用
AU2022257000A1 (en) * 2021-04-14 2023-11-30 Nicole Christine HENWOOD Materials and methods for neurofibromin 2/merlin (nf2) gene therapy
WO2022261209A1 (en) * 2021-06-08 2022-12-15 Nf2 Therapeutics, Inc. Compositions and methods for treating neurofibromatic disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448650A4 (en) * 1989-02-01 1992-05-13 The General Hospital Corporation Herpes simplex virus type i expression vector
WO1993003743A1 (en) * 1991-08-16 1993-03-04 The General Hospital Corporation Method of gene delivery to post-mitotic cells
US5578462A (en) * 1994-01-10 1996-11-26 Bristol-Myers Squibb Company NF2 isoforms

Also Published As

Publication number Publication date
DE69424209D1 (de) 2000-06-08
ATE192489T1 (de) 2000-05-15
EP0613945A3 (en) 1996-01-17
GR3034057T3 (en) 2000-11-30
EP0613945A2 (en) 1994-09-07
DK0613945T3 (da) 2000-09-25
JPH07143884A (ja) 1995-06-06
DE69424209T2 (de) 2001-01-25
CA2115404A1 (en) 1994-08-26
EP0613945B1 (en) 2000-05-03
US5707863A (en) 1998-01-13
PT613945E (pt) 2000-10-31
US6077685A (en) 2000-06-20

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