ES2148760T3 - Metodo para el diagnostico de la esquizofrenia. - Google Patents

Metodo para el diagnostico de la esquizofrenia.

Info

Publication number
ES2148760T3
ES2148760T3 ES96914258T ES96914258T ES2148760T3 ES 2148760 T3 ES2148760 T3 ES 2148760T3 ES 96914258 T ES96914258 T ES 96914258T ES 96914258 T ES96914258 T ES 96914258T ES 2148760 T3 ES2148760 T3 ES 2148760T3
Authority
ES
Spain
Prior art keywords
schizophrenia
diagnosis
humth01
microsatelite
alel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96914258T
Other languages
English (en)
Inventor
Claudine Laurent
Jacques Mallet
Rolando Meloni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2148760T3 publication Critical patent/ES2148760T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA INVENCION CONSISTE EN UN METODO DE DIAGNOSTICO DE LA ESQUIZOFRENIA BASADO EN LA DETECCION IN VITRO DE LA PRESENCIA DEL ALELO EP DEL MICROSATELITE HUMTH01 EN EL GEN TH. LA INVENCION ESTA RELACIONADA ASIMISMO CON LOS PRINCIPIOS UTILIZADOS PARA DESARROLLAR ESTE METODO.
ES96914258T 1995-05-03 1996-04-29 Metodo para el diagnostico de la esquizofrenia. Expired - Lifetime ES2148760T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9505264A FR2733766B1 (fr) 1995-05-03 1995-05-03 Methode de diagnostic de la schizophrenie

Publications (1)

Publication Number Publication Date
ES2148760T3 true ES2148760T3 (es) 2000-10-16

Family

ID=9478648

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96914258T Expired - Lifetime ES2148760T3 (es) 1995-05-03 1996-04-29 Metodo para el diagnostico de la esquizofrenia.

Country Status (29)

Country Link
US (1) US6210879B1 (es)
EP (1) EP0826068B1 (es)
JP (1) JPH11504809A (es)
KR (1) KR19990008221A (es)
CN (1) CN1125881C (es)
AP (1) AP770A (es)
AT (1) ATE193559T1 (es)
AU (1) AU715264B2 (es)
BG (1) BG63017B1 (es)
BR (1) BR9608432A (es)
CA (1) CA2217332A1 (es)
CZ (1) CZ291234B6 (es)
DE (1) DE69608682T2 (es)
DK (1) DK0826068T3 (es)
EA (1) EA001037B1 (es)
ES (1) ES2148760T3 (es)
FR (1) FR2733766B1 (es)
GR (1) GR3033592T3 (es)
HU (1) HUP9802918A3 (es)
NO (1) NO974974D0 (es)
NZ (1) NZ308132A (es)
OA (1) OA10534A (es)
PL (1) PL183819B1 (es)
PT (1) PT826068E (es)
RO (1) RO116731B1 (es)
SI (1) SI0826068T1 (es)
SK (1) SK282119B6 (es)
UA (1) UA49827C2 (es)
WO (1) WO1996034980A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566065B1 (en) * 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
WO1998023733A2 (en) 1996-11-27 1998-06-04 University Of Washington Thermostable polymerases having altered fidelity
WO2002016653A2 (en) 2000-08-24 2002-02-28 University Of Pittsburgh Methods and systems for facilitating the diagnosis and treatment of schizophrenia
WO2002018548A2 (en) * 2000-08-30 2002-03-07 Thomas Jefferson University Tyrosine hydroxylase 5' control elements and uses thereof
US20070072233A1 (en) * 2001-05-01 2007-03-29 Levitt Pat R Methods and systems for facilitating the diagnosis and treatment of schizophrenia
DE10141464A1 (de) * 2001-08-23 2004-03-04 Genprofile Ag I.Ins. Sequenzvarianten des für neuropsychiatrische Krankheiten verantwortlichen Gens 22444 und deren Verwendung
US6764824B2 (en) * 2002-03-21 2004-07-20 Council Of Scientific And Industrial Research Primers for screening schizophrenia and a method thereof
WO2004101818A1 (en) * 2003-05-19 2004-11-25 Institute Of Mental Health, Peking University Detecting method of the schizophrenia susceptible gene and use
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
CA2738578C (en) 2008-09-23 2021-05-04 Quantalife, Inc. Droplet-based assay system
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8633015B2 (en) * 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
EP2556170A4 (en) 2010-03-25 2014-01-01 Quantalife Inc TRAPPING TRANSPORT AND DETECTION SYSTEM
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
SG190074A1 (en) 2010-11-01 2013-06-28 Bio Rad Laboratories System for forming emulsions
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
AU2012231098B2 (en) 2011-03-18 2016-09-29 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
CN107677831A (zh) * 2017-06-28 2018-02-09 深圳市龙岗中心医院 测定用于评估精神分裂症病人的诊断标志物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861504A (en) * 1991-05-29 1999-01-19 The United States Of America As Represented By The Department Of Health And Human Services Eleven highly informative microsatelite repeat polymorphic DNA markers

Also Published As

Publication number Publication date
AU5767896A (en) 1996-11-21
NO974974L (no) 1997-10-28
NZ308132A (en) 1999-10-28
SK282119B6 (sk) 2001-11-06
CN1125881C (zh) 2003-10-29
BG63017B1 (bg) 2001-01-31
HUP9802918A2 (hu) 1999-03-29
RO116731B1 (ro) 2001-05-30
EA199700355A1 (ru) 1998-08-27
DK0826068T3 (da) 2000-08-28
HUP9802918A3 (en) 2001-01-29
FR2733766B1 (fr) 1997-06-06
CZ346797A3 (cs) 1998-01-14
BG102016A (en) 1998-11-30
SK147997A3 (en) 1998-05-06
FR2733766A1 (fr) 1996-11-08
EP0826068A1 (fr) 1998-03-04
EP0826068B1 (fr) 2000-05-31
OA10534A (fr) 2002-04-29
DE69608682D1 (de) 2000-07-06
EA001037B1 (ru) 2000-08-28
WO1996034980A1 (fr) 1996-11-07
KR19990008221A (ko) 1999-01-25
BR9608432A (pt) 1999-03-02
CN1183122A (zh) 1998-05-27
NO974974D0 (no) 1997-10-28
CA2217332A1 (fr) 1996-11-07
CZ291234B6 (cs) 2003-01-15
DE69608682T2 (de) 2000-10-26
US6210879B1 (en) 2001-04-03
JPH11504809A (ja) 1999-05-11
SI0826068T1 (en) 2000-10-31
ATE193559T1 (de) 2000-06-15
UA49827C2 (uk) 2002-10-15
PL183819B1 (pl) 2002-07-31
PL323178A1 (en) 1998-03-16
GR3033592T3 (en) 2000-09-29
PT826068E (pt) 2000-12-29
AP770A (en) 1999-10-06
AU715264B2 (en) 2000-01-20
AP9701126A0 (en) 1997-10-31

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