ES2150719T3 - Analogos de vitamina d3 fluorados. - Google Patents

Analogos de vitamina d3 fluorados.

Info

Publication number
ES2150719T3
ES2150719T3 ES97107848T ES97107848T ES2150719T3 ES 2150719 T3 ES2150719 T3 ES 2150719T3 ES 97107848 T ES97107848 T ES 97107848T ES 97107848 T ES97107848 T ES 97107848T ES 2150719 T3 ES2150719 T3 ES 2150719T3
Authority
ES
Spain
Prior art keywords
fluorated
vitamin analogs
disorders
hydroxy
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97107848T
Other languages
English (en)
Inventor
Bernard Michael Hennessy
Milan Radoje Uskokovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2150719T3 publication Critical patent/ES2150719T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN COMPUESTO DE FORMULA I DONDE R ES HIDROGENO, FLUOR O HIDROXI, Y X ES = CH{SUB,2} O CUANDO R ES HIDROXI, X ES HIDROGENO O = CH{SUB,2}, QUE ES UTIL EN EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS, TRASTORNOS NEOPLASICOS Y TRASTORNOS DE LAS GLANDULAS SEBACEAS.
ES97107848T 1996-05-23 1997-05-14 Analogos de vitamina d3 fluorados. Expired - Lifetime ES2150719T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1818796P 1996-05-23 1996-05-23

Publications (1)

Publication Number Publication Date
ES2150719T3 true ES2150719T3 (es) 2000-12-01

Family

ID=21786696

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97107848T Expired - Lifetime ES2150719T3 (es) 1996-05-23 1997-05-14 Analogos de vitamina d3 fluorados.

Country Status (30)

Country Link
US (1) US5888994A (es)
EP (1) EP0808831B1 (es)
JP (1) JP2858571B2 (es)
KR (1) KR100237523B1 (es)
CN (1) CN1081184C (es)
AR (1) AR007240A1 (es)
AT (1) ATE195514T1 (es)
AU (1) AU720098B2 (es)
BR (1) BR9703373A (es)
CA (1) CA2204478C (es)
CO (1) CO4840512A1 (es)
CZ (1) CZ157997A3 (es)
DE (1) DE69702812T2 (es)
DK (1) DK0808831T3 (es)
ES (1) ES2150719T3 (es)
GR (1) GR3034832T3 (es)
HR (1) HRP970274A2 (es)
HU (1) HUP9700927A3 (es)
IL (1) IL120842A0 (es)
MA (1) MA24345A1 (es)
NO (1) NO971934L (es)
NZ (1) NZ314838A (es)
PL (1) PL320131A1 (es)
PT (1) PT808831E (es)
SG (1) SG50831A1 (es)
TR (1) TR199700418A3 (es)
TW (1) TW374762B (es)
UY (1) UY24563A1 (es)
YU (1) YU19997A (es)
ZA (1) ZA974334B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
WO1998051678A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
DE69834109T2 (de) * 1997-05-16 2007-04-19 Woman & Infants Hospital 3-epi-vitamin d2 verbindungen und ihre anwendungen
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
AU3390400A (en) * 1999-03-05 2000-09-21 Johns Hopkins University, The Regulating skin appearance and composition with a fluorinated vitamin d3 analog compound
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
CA2882048C (en) 2006-02-03 2020-03-24 Opko Renal, Llc Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
HUE037309T2 (hu) 2006-06-21 2018-08-28 Opko Ireland Global Holdings Ltd Terápia D-vitamin telítési szer alkalmazásával és D-vitamin hormon helyettesítõ szer
WO2009047644A2 (en) 2007-04-25 2009-04-16 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
ES2401205T3 (es) 2007-04-25 2013-04-17 Cytochroma Inc. Composiciones de orales de liberación controlada que comprende un compuesto de vitamina D y un soporte céreo
CN103037902A (zh) 2010-03-29 2013-04-10 赛特克罗公司 用于降低甲状旁腺水平的方法和组合物
US8754067B2 (en) 2010-11-12 2014-06-17 Wisconsin Alumni Research Foundation 22-haloacetoxy-homopregnacalciferol analogs and their uses
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
EP4596045A3 (en) 2016-03-28 2025-10-15 EirGen Pharma Ltd. Methods of vitamin d treatment

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039671A (en) * 1984-12-19 1991-08-13 Hoffmann-La Roche Inc. Trifluorinated-1α,25S-dihydroxy vitamin D3 compounds
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
US5210237A (en) * 1991-08-27 1993-05-11 Daikin Industries, Ltd. Vitamin d3 analogues
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
GB9206648D0 (en) * 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
ES2091515T3 (es) * 1992-05-20 1996-11-01 Hoffmann La Roche Analogos fluorados de la vitamina d3.
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
TW267161B (es) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US5384314B1 (en) * 1994-03-11 1997-08-05 Hoffmann La Roche 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger

Also Published As

Publication number Publication date
CO4840512A1 (es) 1999-09-27
IL120842A0 (en) 1997-09-30
HRP970274A2 (en) 1998-04-30
CN1081184C (zh) 2002-03-20
AU720098B2 (en) 2000-05-25
HUP9700927A3 (en) 1999-07-28
CZ157997A3 (en) 1997-12-17
HUP9700927A2 (hu) 1998-01-28
DE69702812D1 (de) 2000-09-21
ZA974334B (en) 1997-11-24
KR970074763A (ko) 1997-12-10
CN1169425A (zh) 1998-01-07
MX9703776A (es) 1998-06-30
TR199700418A2 (xx) 1997-12-21
TR199700418A3 (tr) 1997-12-21
AR007240A1 (es) 1999-10-27
BR9703373A (pt) 1998-09-15
AU2357297A (en) 1997-11-27
DK0808831T3 (da) 2001-01-02
NO971934D0 (no) 1997-04-25
PL320131A1 (en) 1997-11-24
HU9700927D0 (en) 1997-07-28
ATE195514T1 (de) 2000-09-15
EP0808831A3 (en) 1999-02-03
UY24563A1 (es) 2000-12-29
DE69702812T2 (de) 2001-01-25
NZ314838A (en) 1998-01-26
EP0808831B1 (en) 2000-08-16
SG50831A1 (en) 1998-07-20
TW374762B (en) 1999-11-21
CA2204478A1 (en) 1997-11-23
MA24345A1 (fr) 1998-07-01
JPH1045712A (ja) 1998-02-17
KR100237523B1 (ko) 2000-01-15
US5888994A (en) 1999-03-30
GR3034832T3 (en) 2001-02-28
JP2858571B2 (ja) 1999-02-17
EP0808831A2 (en) 1997-11-26
NO971934L (no) 1997-11-24
PT808831E (pt) 2000-12-29
YU19997A (sh) 1999-07-28
CA2204478C (en) 2006-11-21

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