ES2152306T3 - Anticuerpos monoclonales reactivos con regiones definidas del receptor del antigeno de la celula t. - Google Patents

Anticuerpos monoclonales reactivos con regiones definidas del receptor del antigeno de la celula t.

Info

Publication number
ES2152306T3
ES2152306T3 ES94908854T ES94908854T ES2152306T3 ES 2152306 T3 ES2152306 T3 ES 2152306T3 ES 94908854 T ES94908854 T ES 94908854T ES 94908854 T ES94908854 T ES 94908854T ES 2152306 T3 ES2152306 T3 ES 2152306T3
Authority
ES
Spain
Prior art keywords
cell
antigen
receiver
defined regions
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908854T
Other languages
English (en)
Inventor
Charles William Rittershaus
Patrick Kung
Nancy Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2152306T3 publication Critical patent/ES2152306T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

EL INVENTO SE REFIERE A REACTIVOS DE ANTICUERPOS MONOCLONALES CON UN MIEMBRO DE LA REGION VARIABLE DE LA FAMILIA VBETA3 DE LA CADENA BETA DE TCR. MAS PARTICULARMENTE, EL INVENTO HACE PROVISION PARA LA DETECCION DE LA SUBFAMILIA VBETA3.1. EN UNA PRESENTACION ESPECIFICA EL INVENTO PROPORCIONA IDENTIFICACION DE VBETA3.1, SIN REACCION TRANSVERSAL CON OTRAS REGIONES VARIABLES DE LA FAMILIA VBETA3. EN UNA PRESENTACION ESPECIFICA, LOS ANTICUERPOS MONOCLONALES DEL INVENTO NO REACCIONAN CON VBETA3.2. EN PARTICULAR, EL INVENTO PROPORCIONA ANTICUERPOS MONOCLONALES, DENOMINADOS 5E4 Y 8F10, QUE REACCIONAN CON LA REGION VARIABLE DE UN ELEMENTO DE LA FAMILIA VBETA3. EN VARIAS PRESENTACIONES DEL INVENTO, ESTOS ANTICUERPOS, O SUS FRAGMENTOS O DERIVADOS, SE PUEDEN UTILIZAR PARA LIGAR CON UN ELEMENTO DE SECUENCIAS AMINOACIDAS DE REGION VARIABLE TCR DE LA FAMILIA VBETA3, YA COMO PARTE DE UN TCR INTACTO O PEPTIDO, O MOLECULA DE SUPERFICIE DE CELULA T, O UN FRAGMENTO SUYO. LOS ANTICUERPOS MONOCLONALES SON UTILESPARA EL DIAGNOSTICO O TERAPIA DE LA ENFERMEDAD AUTOINMUNE, EN PARTICULAR ARTRITIS REUMATOIDE.
ES94908854T 1992-08-31 1993-08-27 Anticuerpos monoclonales reactivos con regiones definidas del receptor del antigeno de la celula t. Expired - Lifetime ES2152306T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/938,906 US5766947A (en) 1988-12-14 1992-08-31 Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor

Publications (1)

Publication Number Publication Date
ES2152306T3 true ES2152306T3 (es) 2001-02-01

Family

ID=25472181

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908854T Expired - Lifetime ES2152306T3 (es) 1992-08-31 1993-08-27 Anticuerpos monoclonales reactivos con regiones definidas del receptor del antigeno de la celula t.

Country Status (12)

Country Link
US (1) US5766947A (es)
EP (2) EP0867451A3 (es)
JP (1) JPH08502246A (es)
AT (1) ATE197316T1 (es)
AU (1) AU705925B2 (es)
CA (1) CA2143186A1 (es)
DE (1) DE69329621T2 (es)
DK (1) DK0662148T3 (es)
ES (1) ES2152306T3 (es)
GR (1) GR3035090T3 (es)
PT (1) PT662148E (es)
WO (1) WO1994005801A1 (es)

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GB9906233D0 (en) * 1999-03-19 1999-05-12 Univ Newcastle Bone formation
DE60042785D1 (de) * 1999-06-09 2009-10-01 Immunomedics Inc Immuntherapie von autoimmunerkrankungen durch die verwendung von b-zell spezifischen antikörpern
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US20050084967A1 (en) * 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
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AU2016273213B2 (en) 2015-06-01 2019-03-14 Medigene Immunotherapies Gmbh T cell receptor library
WO2016193300A1 (en) 2015-06-01 2016-12-08 Medigene Immunotherapies Gmbh Method for generating antibodies against t cell receptor
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US11459540B2 (en) * 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
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RU2694412C9 (ru) 2017-12-25 2019-09-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) Моноклональные антитела и способы их применения
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
EP3765517A1 (en) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
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RU2712251C1 (ru) 2018-12-25 2020-01-27 Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) Гуманизированные антитела против участка бета цепи 9-го семейства TRBV9 TKP человека, и способы их применения
JP7700039B2 (ja) * 2019-01-04 2025-06-30 マレンゴ・セラピューティクス，インコーポレーテッド 抗ｔｃｒ抗体分子およびその使用
SG11202109122SA (en) * 2019-02-21 2021-09-29 Marengo Therapeutics Inc Anti-tcr antibody molecules and uses thereof
JP7579795B2 (ja) 2019-02-21 2024-11-08 マレンゴ・セラピューティクス，インコーポレーテッド ＮＫｐ３０に結合する抗体分子およびその使用
AU2020226893B2 (en) 2019-02-21 2025-02-27 Marengo Therapeutics, Inc. Multifunctional molecules that bind to T cell related cancer cells and uses thereof
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Also Published As

Publication number Publication date
DK0662148T3 (da) 2000-12-18
DE69329621D1 (de) 2000-12-07
CA2143186A1 (en) 1994-03-17
EP0867451A3 (en) 2000-03-29
ATE197316T1 (de) 2000-11-15
DE69329621T2 (de) 2001-03-08
US5766947A (en) 1998-06-16
PT662148E (pt) 2001-04-30
GR3035090T3 (en) 2001-03-30
EP0662148B1 (en) 2000-11-02
WO1994005801A1 (en) 1994-03-17
AU4971393A (en) 1994-03-29
AU705925B2 (en) 1999-06-03
JPH08502246A (ja) 1996-03-12
EP0662148A1 (en) 1995-07-12
EP0867451A2 (en) 1998-09-30

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