ES2152865B1 - Utilizacion de bisfosfonatos en la preparacion de composiciones farmaceuticas para uso intramuscular. - Google Patents

Utilizacion de bisfosfonatos en la preparacion de composiciones farmaceuticas para uso intramuscular.

Info

Publication number: ES2152865B1
Authority: ES; Spain
Prior art keywords: bisphosphonates; preparation; acid; intramuscular; pharmaceutical compositions
Prior art date: 1997-11-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

ES9802412A

Other languages

English (en)

Spanish (es)

Other versions

ES2152865A1 (es

Inventor

Tiberio Bruzzesse

Angelo Bonabello

Giovanni Mozzi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Prodotti Antibiotici SpA

Original Assignee

Prodotti Antibiotici SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-21

Filing date

1998-11-17

Publication date

2001-08-16

1998-11-17 Application filed by Prodotti Antibiotici SpA filed Critical Prodotti Antibiotici SpA

2001-02-01 Publication of ES2152865A1 publication Critical patent/ES2152865A1/es

2001-08-16 Application granted granted Critical

2001-08-16 Publication of ES2152865B1 publication Critical patent/ES2152865B1/es

2018-11-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

229940122361 Bisphosphonate Drugs 0.000 title abstract 4
150000004663 bisphosphonates Chemical class 0.000 title abstract 4
238000007918 intramuscular administration Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 abstract 1
229960004343 alendronic acid Drugs 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
229960002286 clodronic acid Drugs 0.000 abstract 1
ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 abstract 1
229960004585 etidronic acid Drugs 0.000 abstract 1
MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical compound OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 abstract 1
229960003074 medronic acid Drugs 0.000 abstract 1
WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 abstract 1
229960003978 pamidronic acid Drugs 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

ES9802412A 1997-11-21 1998-11-17 Utilizacion de bisfosfonatos en la preparacion de composiciones farmaceuticas para uso intramuscular. Expired - Fee Related ES2152865B1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT002603 IT1296495B1 (it)	1997-11-21	1997-11-21	Impiego di bisfosfonati nella preparazione di forme farmaceutiche per somministrazione intramuscolare

Publications (2)

Publication Number	Publication Date
ES2152865A1 ES2152865A1 (es)	2001-02-01
ES2152865B1 true ES2152865B1 (es)	2001-08-16

Family

ID=11378254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES9802412A Expired - Fee Related ES2152865B1 (es)	1997-11-21	1998-11-17	Utilizacion de bisfosfonatos en la preparacion de composiciones farmaceuticas para uso intramuscular.

Country Status (6)

Country	Link
BE (1)	BE1012137A3 (fr)
DE (1)	DE19853483A1 (fr)
ES (1)	ES2152865B1 (fr)
FR (1)	FR2771638B1 (fr)
GB (1)	GB2331459A (fr)
IT (1)	IT1296495B1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1136069A1 (fr) *	2000-03-21	2001-09-26	SPA SOCIETA' PRODOTTI ANTIBIOTICI S.p.A.	Compositions pharmaceutiques comprenant des clodronates ayant une haute tolérance locale de l'administration intramusculaire
CA2410201C (fr)	2000-06-20	2010-10-26	Novartis Ag	Acide zoledronique et ses sels utilises pour le traitement des affections caracterisees par un renouvellement exagere des cellules osseuses
EP1591122B1 (fr) *	2000-06-20	2012-09-26	Novartis AG	Méthode pour l'administration de biphosphonates
US6548042B2 (en)	2000-08-07	2003-04-15	Arstad Erik	Bis-phosphonate compounds
ITTO20020406A1 (it) *	2002-05-13	2003-11-13	Chiesi Farma Spa	Formulazioni di bisfosfonati ad uso iniettabile.
EP1605900A4 (fr) *	2003-03-26	2007-10-17	Becton Dickinson Co	Utilisation d'alcool benzylique et d'autres agents de preservation phenoliques pour reduire la douleur durant une injection intradermique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0051163A3 (fr) *	1980-11-03	1983-02-16	Dr. Franz Köhler Chemie KG	Solution du chlorhydrate de 4-diméthylaminophénol à utilisation intramusculaire sans douleur et procédé de préparation
JPS5862652A (ja) *	1981-10-08	1983-04-14	Konishiroku Photo Ind Co Ltd	直接ポジカラ−画像の形成方法
JPH03190823A (ja) *	1989-12-21	1991-08-20	Snow Brand Milk Prod Co Ltd	エリスロポエチン皮下又は筋肉投与剤
CA2035179C (fr) *	1990-01-31	2001-08-14	Gerald S. Brenner	Composition pharmaceutique contenant des sels insolubles d'acides biphosphonique
HUT75224A (en) *	1993-10-19	1997-04-28	Merck & Co Inc	Combination of bisphosphonates and growth hormone secretagogues
US5646134A (en) *	1994-04-21	1997-07-08	Merck & Co., Inc.	Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices

1997
- 1997-11-21 IT IT002603 patent/IT1296495B1/it active IP Right Grant
1998
- 1998-11-17 ES ES9802412A patent/ES2152865B1/es not_active Expired - Fee Related
- 1998-11-19 FR FR9814554A patent/FR2771638B1/fr not_active Expired - Fee Related
- 1998-11-19 GB GB9825409A patent/GB2331459A/en not_active Withdrawn
- 1998-11-19 DE DE1998153483 patent/DE19853483A1/de not_active Ceased
- 1998-11-20 BE BE9800841A patent/BE1012137A3/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB2331459A8 (en)	1999-07-15
IT1296495B1 (it)	1999-06-25
GB9825409D0 (en)	1999-01-13
BE1012137A3 (fr)	2000-05-02
DE19853483A1 (de)	1999-05-27
FR2771638A1 (fr)	1999-06-04
FR2771638B1 (fr)	2000-09-08
ITMI972603A1 (it)	1999-05-21
GB2331459A (en)	1999-05-26
ES2152865A1 (es)	2001-02-01

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