ES2159232B1 - Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. - Google Patents
Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.Info
- Publication number
- ES2159232B1 ES2159232B1 ES009900730A ES9900730A ES2159232B1 ES 2159232 B1 ES2159232 B1 ES 2159232B1 ES 009900730 A ES009900730 A ES 009900730A ES 9900730 A ES9900730 A ES 9900730A ES 2159232 B1 ES2159232 B1 ES 2159232B1
- Authority
- ES
- Spain
- Prior art keywords
- resolution
- enantiomeric mixtures
- organic acids
- propionic
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 150000007524 organic acids Chemical class 0.000 title abstract 3
- 235000005985 organic acids Nutrition 0.000 title abstract 3
- 230000002255 enzymatic effect Effects 0.000 title abstract 2
- -1 4 - isobutylphenyl Chemical group 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004882 Lipase Human genes 0.000 abstract 2
- 108090001060 Lipase Proteins 0.000 abstract 2
- 239000004367 Lipase Substances 0.000 abstract 2
- 239000011942 biocatalyst Substances 0.000 abstract 2
- 235000019421 lipase Nutrition 0.000 abstract 2
- 241001313476 Arthroderma ciferrii Species 0.000 abstract 1
- 235000012539 Bacterium linens Nutrition 0.000 abstract 1
- 241000186310 Brevibacterium linens Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000223221 Fusarium oxysporum Species 0.000 abstract 1
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 241000223252 Rhodotorula Species 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012847 fine chemical Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 150000004672 propanoic acids Chemical class 0.000 abstract 1
- 235000019260 propionic acid Nutrition 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Procedimientos enzimáticos para la resolución de mezclas enantioméricas de ácidos orgánicos. La presente invención se refiere a un procedimiento para la resolución de mezclas enantioméricas de ácidos orgánicos, en particular, a la resolución de mezclas enantioméricas de ácidos propiónicos, y más en particular, a la resolución de los ácidos (R,S) 2(4- isobutilfenil) propiónico y (R,S) 2-(3-benzoilfenil) propiónico. El procedimiento consiste en hacer reaccionar en el seno de un disolvente orgánico apolar la mezcla a resolver con un alcohol en presencia de un biocatalizador, y la posterior separación del éster enantioméricamente enriquecido de los productos de partida. Dicho biocatalizador es una lipasa, o mezcla de lipasas, en diversos grados de purificación, producida por un microorganismo seleccionado del siguiente grupo: Fusarium oxysporum, Arthroderma ciferrii, Monascus mucoroides, Ovadendron sulphureoochraceum, Brevibacterium linens, Streptomyces fradiae y Rhodotorula araucariae. Dichosprocedimientos son de interés en la industria farmacéutica e industria de química fina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009900730A ES2159232B1 (es) | 1999-04-09 | 1999-04-09 | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009900730A ES2159232B1 (es) | 1999-04-09 | 1999-04-09 | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2159232A1 ES2159232A1 (es) | 2001-09-16 |
| ES2159232B1 true ES2159232B1 (es) | 2002-04-01 |
Family
ID=8307964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009900730A Expired - Fee Related ES2159232B1 (es) | 1999-04-09 | 1999-04-09 | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2159232B1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK289083A (da) * | 1983-06-23 | 1984-12-24 | Novo Industri As | Lipase, fremgangsmaade til fremstilling deraf og anvendelse deraf |
| CA2023856A1 (en) * | 1989-09-26 | 1991-03-27 | Jeffrey M. Howell | Enzymatic resolution process |
| CA2132411A1 (en) * | 1994-09-19 | 1996-03-20 | Michael Trani | Enzymatic esterification of long-chain racemic acids and alcohols |
-
1999
- 1999-04-09 ES ES009900730A patent/ES2159232B1/es not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2159232A1 (es) | 2001-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Baumann et al. | Rapid screening of hydrolases for the enantioselective conversion of ‘difficult-to-resolve’substrates | |
| Yamamoto et al. | Asymmetric Synthesis of Optically Active Lactones from Cyclic Acid Anhydrides Using Lipase in Organic Solvents1 | |
| JP3798467B2 (ja) | 高度不飽和脂肪酸の酵素分画方法 | |
| Barbayianni et al. | Biocatalyzed Regio‐and Chemoselective Ester Cleavage: Synthesis of Bioactive Molecules | |
| Wang et al. | Enzymatic desymmetrization of 3-alkyl-and 3-arylglutaronitriles, a simple and convenient approach to optically active 4-amino-3-phenylbutanoic acids | |
| DE3378206D1 (en) | Process for the preparation of a free alpha-l-amino acid | |
| Lanser | Conversion of oleic acid to 10‐ketostearic acid by aStaphylococcus species | |
| López-Garcı́a et al. | Desymmetrization of dimethyl 3-substituted glutarates through enzymatic ammonolysis and aminolysis reactions | |
| ES2159232A1 (es) | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. | |
| CA2161849A1 (en) | Production of optically active compounds | |
| EP0178553A3 (en) | Process for the production of aromatic substituted l-amino acids | |
| JPH0889282A (ja) | 立体異性アルコール混合物の分解方法 | |
| JPH0260599A (ja) | 酵素分解方法 | |
| JPH03119996A (ja) | 酵素的分割方法 | |
| ATE170771T1 (de) | Verfahren zur desodorierung und stabilisierung biotechnologisch gewonnener wertstoffe und ihrer wässrigen zubereitungen | |
| EP0997534A3 (de) | Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern | |
| ES2159231B1 (es) | Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas. | |
| DE68912236D1 (de) | Verfahren zur Herstellung von hochgradig ungesättigten Fettsäuren. | |
| JPH09124564A (ja) | 光学活性体混合物ならびにその製造方法 | |
| JP2707642B2 (ja) | リゾリン脂質の製造法 | |
| Kiełbasiński | On the applicability of the Jones active site model of pig liver esterase to S-chiral and prochiral sulfinyl substrates | |
| DE69323600D1 (de) | Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure | |
| JP4331896B2 (ja) | リゾスフィンゴ脂質の製造方法 | |
| EP0264429A1 (en) | ENZYMATIC PROCESS FOR PREPARING OPTICALLY-ACTIVE 1,2-DIHYDRO-3H-PYRROLO 1,2a]PYRROLE-1-CARBOXYLIC ACID DERIVATIVES | |
| EP0467132B1 (en) | 4-Substituted-2-hydroxybutanoates and a process for producing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20160120 Kind code of ref document: A1 Effective date: 20160120 |
|
| PC2A | Transfer of patent | ||
| FD2A | Announcement of lapse in spain |
Effective date: 20180807 |