ES2159232A1 - Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. - Google Patents
Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.Info
- Publication number
- ES2159232A1 ES2159232A1 ES009900730A ES9900730A ES2159232A1 ES 2159232 A1 ES2159232 A1 ES 2159232A1 ES 009900730 A ES009900730 A ES 009900730A ES 9900730 A ES9900730 A ES 9900730A ES 2159232 A1 ES2159232 A1 ES 2159232A1
- Authority
- ES
- Spain
- Prior art keywords
- resolution
- enantiomeric mixtures
- alcohol
- propionic
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 102000004882 Lipase Human genes 0.000 title abstract 3
- 108090001060 Lipase Proteins 0.000 title abstract 3
- 239000004367 Lipase Substances 0.000 title abstract 3
- 235000019421 lipase Nutrition 0.000 title abstract 3
- 150000007524 organic acids Chemical class 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title abstract 2
- 239000003960 organic solvent Substances 0.000 title abstract 2
- 238000006555 catalytic reaction Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000011942 biocatalyst Substances 0.000 abstract 2
- 235000005985 organic acids Nutrition 0.000 abstract 2
- 241001313476 Arthroderma ciferrii Species 0.000 abstract 1
- 235000012539 Bacterium linens Nutrition 0.000 abstract 1
- 241000186310 Brevibacterium linens Species 0.000 abstract 1
- 241000223221 Fusarium oxysporum Species 0.000 abstract 1
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 241000007095 Rhodotorula araucariae Species 0.000 abstract 1
- 241000187438 Streptomyces fradiae Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012847 fine chemical Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 150000004672 propanoic acids Chemical class 0.000 abstract 1
- 235000019260 propionic acid Nutrition 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Procedimientos enzimáticos para la resolución de mezclas enantioméricas de ácidos orgánicos. La presente invención se refiere a un procedimiento para la resolución de mezclas enantioméricas de ácidos orgánicos, en particular, a la resolución de mezclas enantioméricas de ácidos propiónicos, y más en particular, a la resolución de los ácidos (R,S) 2(4- isobutilfenil) propiónico y (R,S) 2-(3-benzoilfenil) propiónico. El procedimiento consiste en hacer reaccionar en el seno de un disolvente orgánico apolar la mezcla a resolver con un alcohol en presencia de un biocatalizador, y la posterior separación del éster enantioméricamente enriquecido de los productos de partida. Dicho biocatalizador es una lipasa, o mezcla de lipasas, en diversos grados de purificación, producida por un microorganismo seleccionado del siguiente grupo: Fusarium oxysporum, Arthroderma ciferrii, Monascus mucoroides, Ovadendron sulphureoochraceum, Brevibacterium linens, Streptomyces fradiae y Rhodotorula araucariae. Dichosprocedimientos son de interés en la industria farmacéutica e industria de química fina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009900730A ES2159232B1 (es) | 1999-04-09 | 1999-04-09 | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009900730A ES2159232B1 (es) | 1999-04-09 | 1999-04-09 | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2159232A1 true ES2159232A1 (es) | 2001-09-16 |
| ES2159232B1 ES2159232B1 (es) | 2002-04-01 |
Family
ID=8307964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009900730A Expired - Fee Related ES2159232B1 (es) | 1999-04-09 | 1999-04-09 | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2159232B1 (es) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0130064A1 (en) * | 1983-06-23 | 1985-01-02 | Novo Nordisk A/S | Improvements in and relating to an enzymatic detergent additive, a detergent, and a washing method |
| EP0421636A1 (en) * | 1989-09-26 | 1991-04-10 | E.R. SQUIBB & SONS, INC. | Enzymatic resolution process |
| US5561057A (en) * | 1994-09-19 | 1996-10-01 | National Research Council Of Canada | Resolution of (RS)-ibuprofen by Candida antarctica catalyzed esterification with long chain alcohols while removing water |
-
1999
- 1999-04-09 ES ES009900730A patent/ES2159232B1/es not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0130064A1 (en) * | 1983-06-23 | 1985-01-02 | Novo Nordisk A/S | Improvements in and relating to an enzymatic detergent additive, a detergent, and a washing method |
| EP0421636A1 (en) * | 1989-09-26 | 1991-04-10 | E.R. SQUIBB & SONS, INC. | Enzymatic resolution process |
| US5561057A (en) * | 1994-09-19 | 1996-10-01 | National Research Council Of Canada | Resolution of (RS)-ibuprofen by Candida antarctica catalyzed esterification with long chain alcohols while removing water |
Non-Patent Citations (4)
| Title |
|---|
| BRAHIMI-HORN, M-Ch. et al. Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae. Journal of Industrial Microbiology, 1992, Vol. 10, paginas 25-30. * |
| GOTO, M. et al. Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media. Biotechnology Letters. 1996, Vol. 18 (7), paginas 839-844. * |
| HOSHINO et al. Purification and some characteristics of extracellular lipase from Fusarium oxysporum f. sp. lini. Biosci. Biotech. Biochem., 1992, Vol. 56 (4), paginas 660-664. * |
| MUSTRANTA, A. Use of lipases in the resolution of racemic ibuprofen. Appl. Microbiol. Biotechnol., 1992, Vol. 38, paginas 61-66. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2159232B1 (es) | 2002-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20160120 Kind code of ref document: A1 Effective date: 20160120 |
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| PC2A | Transfer of patent | ||
| FD2A | Announcement of lapse in spain |
Effective date: 20180807 |