ES2117281T3 - Nuevos analogos de la vitamina d. - Google Patents

Nuevos analogos de la vitamina d.

Info

Publication number
ES2117281T3
ES2117281T3 ES94920900T ES94920900T ES2117281T3 ES 2117281 T3 ES2117281 T3 ES 2117281T3 ES 94920900 T ES94920900 T ES 94920900T ES 94920900 T ES94920900 T ES 94920900T ES 2117281 T3 ES2117281 T3 ES 2117281T3
Authority
ES
Spain
Prior art keywords
sup
sub
formula
groups
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94920900T
Other languages
English (en)
Inventor
Gunnar Grue-Sorensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of ES2117281T3 publication Critical patent/ES2117281T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA (I) EN CUYA FORMULA X ES HIDROGENO O HIDROXI; R{SUP,1} Y R{SUP,2}, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN HIDROGENO O HIDROCARBILO C{SUB,1}-C{SUB,4}; O R{SUP,1} Y R{SUP,2} JUNTOS Y CON EL ATOMO DE CARBONO QUE CONTIENE EL GRUPO X, PUEDEN FORMAR UN ANILLO CARBOCICLICO C{SUB,3}-C{SUB,8}; Q ES UN ENLACE SENCILLO O UN DIRRADICAL DE HIDROCARBILENO C{SUB,1}-C{SUB,4}; R{SUP,1}, R{SUP,2} Y/O Q PUEDEN SER OPCIONALMENTE SUSTITUIDOS POR UNO O MAS ATOMOS DE FLUOR; Y PROFARMACOS DE LA FORMULA (I) EN LA QUE UNO O MAS DE LOS GRUPOS HIDROXI ESTAN ENMASCARADOS COMO GRUPOS QUE PUEDEN SER RECONVERTIDOS EN GRUPOS HIDROXI IN VIVO. LOS COMPUESTOS PRESENTAN EFECTOS ANTIINFLAMATORIOS E INMUNOMODULADORES ASI COMO UNA FUERTE ACTIVIDAD PARA INDUCIR LA DIFERENCIACION E INHIBIR LA PROLIFERACION NO DESEADA DE CIERTAS CELULAS.
ES94920900T 1993-07-12 1994-07-01 Nuevos analogos de la vitamina d. Expired - Lifetime ES2117281T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939314400A GB9314400D0 (en) 1993-07-12 1993-07-12 Produktionsaktieselskab) chemical compounds

Publications (1)

Publication Number Publication Date
ES2117281T3 true ES2117281T3 (es) 1998-08-01

Family

ID=10738689

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94920900T Expired - Lifetime ES2117281T3 (es) 1993-07-12 1994-07-01 Nuevos analogos de la vitamina d.

Country Status (15)

Country Link
US (1) US5716945A (es)
EP (1) EP0708755B1 (es)
JP (1) JP3773253B2 (es)
KR (1) KR100317869B1 (es)
CN (1) CN1048241C (es)
AT (1) ATE165346T1 (es)
AU (1) AU690564B2 (es)
CA (1) CA2162040A1 (es)
DE (1) DE69409811T2 (es)
ES (1) ES2117281T3 (es)
FI (1) FI111719B (es)
GB (1) GB9314400D0 (es)
NZ (1) NZ268567A (es)
RU (1) RU2130926C1 (es)
WO (1) WO1995002577A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
DE19619036A1 (de) * 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
WO1998001135A1 (fr) * 1996-07-03 1998-01-15 Sanwa Kagaku Kenkyusho Co., Ltd. Agents d'elimination du phosphore, inhibiteurs augmentant le taux serique de parathormone et inhibiteurs de l'osteodystrophie
AU728037B2 (en) 1997-05-22 2001-01-04 Cephalon, Inc. Vitamin D analogues and their neuronal effects
AU8860298A (en) * 1997-07-17 1999-02-10 F. Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain
PL199123B1 (pl) * 1999-04-23 2008-08-29 Leo Pharm Prod Ltd Niewodna kompozycja farmaceutyczna do stosowania naskórnego i jej zastosowanie
ES2240159T3 (es) 1999-09-29 2005-10-16 Colotech A/S Prevencion del cancer colorrectal.
US6703380B2 (en) 1999-09-29 2004-03-09 Colotech A/S Prevention of cancer
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US20020183277A1 (en) * 2001-05-15 2002-12-05 Lise Binderup Combination of vitamin D analogue and pyrimidine nucleoside analogue
BR0315553A (pt) * 2002-10-23 2005-08-23 Leo Pharma As Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, método de tratamento ou profilaxia de hiperparatireoidismo secundário, e, uso de um composto, opcionalmente em conjunto com outro composto terapeuticamente ativo
AR041696A1 (es) 2002-10-23 2005-05-26 Leo Pharm Prod Ltd Compuestos analogos de vitamina d, composiciones que comprenden dichos compuestos analogos y su uso
EP1458678A1 (en) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited A crystallization method for purification of calcipotriene
ES2234423B1 (es) * 2003-12-05 2006-03-01 Laboratorios Viñas, S.A. Procedimiento para la obtencion de derivados de vitamina d a partir de compuestos monohalogenovinilicos.
US20080293647A1 (en) 2004-11-12 2008-11-27 Luciano Adorini Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN103508999B (zh) * 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
KR0144358B1 (ko) * 1988-04-21 1998-07-15 피. 라이달 크리스텐슨 비타민 d 동족체
US5378695A (en) * 1989-02-23 1995-01-03 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Vitamin D analogues
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
GB9226877D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds

Also Published As

Publication number Publication date
CN1125941A (zh) 1996-07-03
JP3773253B2 (ja) 2006-05-10
CA2162040A1 (en) 1995-01-26
WO1995002577A1 (en) 1995-01-26
KR100317869B1 (ko) 2002-09-27
AU690564B2 (en) 1998-04-30
EP0708755B1 (en) 1998-04-22
CN1048241C (zh) 2000-01-12
AU7182994A (en) 1995-02-13
FI956108A7 (fi) 1995-12-19
KR960702436A (ko) 1996-04-27
ATE165346T1 (de) 1998-05-15
FI111719B (fi) 2003-09-15
FI956108A0 (fi) 1995-12-19
US5716945A (en) 1998-02-10
NZ268567A (en) 1997-11-24
GB9314400D0 (en) 1993-08-25
EP0708755A1 (en) 1996-05-01
DE69409811T2 (de) 1999-01-07
DE69409811D1 (de) 1998-05-28
JPH08512327A (ja) 1996-12-24
RU2130926C1 (ru) 1999-05-27

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