ES2162039T3 - Nuevos ciclohexapeptidos antifungicos. - Google Patents

Nuevos ciclohexapeptidos antifungicos.

Info

Publication number
ES2162039T3
ES2162039T3 ES96908446T ES96908446T ES2162039T3 ES 2162039 T3 ES2162039 T3 ES 2162039T3 ES 96908446 T ES96908446 T ES 96908446T ES 96908446 T ES96908446 T ES 96908446T ES 2162039 T3 ES2162039 T3 ES 2162039T3
Authority
ES
Spain
Prior art keywords
cyclohexapeptides
antifungic
new
compounds
carba
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96908446T
Other languages
English (en)
Inventor
Frances A Bouffard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2162039T3 publication Critical patent/ES2162039T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS CARBA CICLOHEXAPEPTIDOS DE FORMULA (I), (SEQ ID NOS. 1-6), DONDE TODOS LOS SUSTITUYENTES ESTAN DEFINIDOS EN ELLA; ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTIFUNGICOS Y PARA EL TRATAMIENTO DE INFECCIONES DE PNEUMOCYSTIS CARINII. ASIMISMO SE DESCRIBEN COMPOSICIONES QUE CONTIENEN LOS COMPUESTOS DE LA INVENCION.
ES96908446T 1995-01-26 1996-01-22 Nuevos ciclohexapeptidos antifungicos. Expired - Lifetime ES2162039T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37868795A 1995-01-26 1995-01-26

Publications (1)

Publication Number Publication Date
ES2162039T3 true ES2162039T3 (es) 2001-12-16

Family

ID=23494135

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96908446T Expired - Lifetime ES2162039T3 (es) 1995-01-26 1996-01-22 Nuevos ciclohexapeptidos antifungicos.

Country Status (11)

Country Link
US (1) US5854213A (es)
EP (1) EP0805685B1 (es)
JP (1) JP2966936B2 (es)
AT (1) ATE206054T1 (es)
AU (1) AU691743B2 (es)
CA (1) CA2211138A1 (es)
DE (1) DE69615535T2 (es)
DK (1) DK0805685T3 (es)
ES (1) ES2162039T3 (es)
PT (1) PT805685E (es)
WO (1) WO1996022784A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2784993B1 (fr) * 1998-10-26 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
UA72200C2 (uk) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
FR2772028B1 (fr) * 1997-12-10 2000-02-04 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
WO2000076556A2 (en) 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
AU6564000A (en) 1999-07-27 2001-02-13 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
JP2003535042A (ja) * 2000-01-20 2003-11-25 バジリア ファルマスーチカ アーゲー 鼻腔に投与可能な環式ペプチド組成物
EP1390081A2 (en) 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
MXPA03009802A (es) * 2001-04-25 2005-03-07 Wyeth Corp Antibioticos de glicopeptidos.
US6914045B2 (en) * 2001-04-25 2005-07-05 Wyeth Holdings Corporation Glycopeptide antibiotics
EP1458416A1 (en) 2001-12-13 2004-09-22 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
WO2012119065A2 (en) 2011-03-03 2012-09-07 Seachaid Pharmaceuticals, Inc. Antifungal agents and uses thereof
SI3677252T1 (sl) 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
MA43825A (fr) 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
JP7779651B2 (ja) 2017-07-12 2025-12-03 ナップ ファーマシューティカル グループ リミテッド 真菌感染症の処置のための組成物及び方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
US5194377A (en) 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
US5202309A (en) 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
IL98506A (en) * 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii
US6030944A (en) * 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
MY136593A (en) * 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
EP0805685B1 (en) 2001-09-26
JPH10505100A (ja) 1998-05-19
ATE206054T1 (de) 2001-10-15
DK0805685T3 (da) 2001-11-19
DE69615535T2 (de) 2002-05-02
EP0805685A1 (en) 1997-11-12
DE69615535D1 (de) 2001-10-31
PT805685E (pt) 2002-02-28
EP0805685A4 (en) 1998-04-29
WO1996022784A1 (en) 1996-08-01
JP2966936B2 (ja) 1999-10-25
AU5168196A (en) 1996-08-14
CA2211138A1 (en) 1996-08-01
AU691743B2 (en) 1998-05-21
US5854213A (en) 1998-12-29

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