ES2168043B1 - Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. - Google Patents

Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.

Info

Publication number
ES2168043B1
ES2168043B1 ES009902027A ES9902027A ES2168043B1 ES 2168043 B1 ES2168043 B1 ES 2168043B1 ES 009902027 A ES009902027 A ES 009902027A ES 9902027 A ES9902027 A ES 9902027A ES 2168043 B1 ES2168043 B1 ES 2168043B1
Authority
ES
Spain
Prior art keywords
pharmaceutical form
oral solid
modified release
bencimidazol
labil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009902027A
Other languages
English (en)
Other versions
ES2168043A1 (es
Inventor
Cabrera Antonio Lopez
Ibarra Pedro Juan Solanas
Vicent Mancinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to ES009902027A priority Critical patent/ES2168043B1/es
Priority to AU57919/00A priority patent/AU777322B2/en
Priority to US09/660,022 priority patent/US6780436B1/en
Priority to CA2318008A priority patent/CA2318008C/en
Priority to AT00500203T priority patent/ATE334679T1/de
Priority to DE60029712T priority patent/DE60029712T2/de
Priority to DK00500203T priority patent/DK1086694T3/da
Priority to PT00500203T priority patent/PT1086694E/pt
Priority to JP2000277838A priority patent/JP4885347B2/ja
Priority to EP00500203A priority patent/EP1086694B1/en
Priority to ES00500203T priority patent/ES2269088T3/es
Priority to KR1020000053939A priority patent/KR100724201B1/ko
Publication of ES2168043A1 publication Critical patent/ES2168043A1/es
Application granted granted Critical
Publication of ES2168043B1 publication Critical patent/ES2168043B1/es
Priority to CY20061101540T priority patent/CY1106219T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Forma farmacéutica sólida oral de liberación modificada que contiene un compuesto de bencimidazol lábil en medio ácido La forma farmacéutica está constituida por una pluralidad de pellets que comprenden un núcleo inerte, una capa con el principio activo, una o más capas intermedias que comprenden al menos un sistema de liberación modificada, y una capa externa de recubrimiento entérico. Estos pellets pueden obtenerse aplicando las distintas capas mediante técnicas de recubrimiento de lecho fluido utilizando soluciones o suspensiones acuosas de los componentes de tales capas. Las formas farmacéuticas pueden ser cápsulas de gelatina duras o comprimidos y son adecuadas para su empleo en la prevención y el tratamiento de trastornos relacionados con una secreción de ácido gástrico anormal.
ES009902027A 1999-09-13 1999-09-13 Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. Expired - Fee Related ES2168043B1 (es)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ES009902027A ES2168043B1 (es) 1999-09-13 1999-09-13 Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.
US09/660,022 US6780436B1 (en) 1999-09-13 2000-09-12 Solid oral pharmaceutical formulation of modified release that contains an acid labile benzimidazole compound
CA2318008A CA2318008C (en) 1999-09-13 2000-09-12 Solid oral pharmaceutical formulation of modified release that contains an acid labile benzimidazole compound
AU57919/00A AU777322B2 (en) 1999-09-13 2000-09-12 Solid oral pharmaceutical formulation of modified release that contains an acid labile benzimidazole compound
PT00500203T PT1086694E (pt) 1999-09-13 2000-09-13 Formulação farmacêutica sólida oral de libertação modificada contendo um composto de benzimidazole sensível a ácidos
DK00500203T DK1086694T3 (da) 1999-09-13 2000-09-13 Oral farmaceutisk formulering i fast form med modificeret frigivelse, der indeholder en syrelabil benzimidazolforbindelse
AT00500203T ATE334679T1 (de) 1999-09-13 2000-09-13 Feste oral anzuwendende arzneizubereitung mit gesteuerter wirkstoffabgabe enthaltend eine säureempfindliche benzimidazolverbindung
JP2000277838A JP4885347B2 (ja) 1999-09-13 2000-09-13 酸に不安定ベンズイミダゾールを含有する修飾された放出特性の経口用固形製剤
EP00500203A EP1086694B1 (en) 1999-09-13 2000-09-13 Solid oral pharmaceutical formulation of modified release that contains an acid labile benzimidazole compound
ES00500203T ES2269088T3 (es) 1999-09-13 2000-09-13 Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.
DE60029712T DE60029712T2 (de) 1999-09-13 2000-09-13 Feste oral anzuwendende Arzneizubereitung mit gesteuerter Wirkstoffabgabe enthaltend eine säureempfindliche Benzimidazolverbindung
KR1020000053939A KR100724201B1 (ko) 1999-09-13 2000-09-14 산에 불안정한 벤즈이미다졸 화합물을 포함하는 방출이변형된 구강용 고형 제약학적 조성물
CY20061101540T CY1106219T1 (el) 1999-09-13 2006-10-25 Στepεο απο του στοματος χορηγουμενο φαρμακευτικο μορφωμα μεταβλητης απελευθερωσης που πepιεχει μια ασταθη στα οξεα της βενζιμιδαζολης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009902027A ES2168043B1 (es) 1999-09-13 1999-09-13 Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.

Publications (2)

Publication Number Publication Date
ES2168043A1 ES2168043A1 (es) 2002-05-16
ES2168043B1 true ES2168043B1 (es) 2003-04-01

Family

ID=8309905

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009902027A Expired - Fee Related ES2168043B1 (es) 1999-09-13 1999-09-13 Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.
ES00500203T Expired - Lifetime ES2269088T3 (es) 1999-09-13 2000-09-13 Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00500203T Expired - Lifetime ES2269088T3 (es) 1999-09-13 2000-09-13 Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.

Country Status (12)

Country Link
US (1) US6780436B1 (es)
EP (1) EP1086694B1 (es)
JP (1) JP4885347B2 (es)
KR (1) KR100724201B1 (es)
AT (1) ATE334679T1 (es)
AU (1) AU777322B2 (es)
CA (1) CA2318008C (es)
CY (1) CY1106219T1 (es)
DE (1) DE60029712T2 (es)
DK (1) DK1086694T3 (es)
ES (2) ES2168043B1 (es)
PT (1) PT1086694E (es)

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MXPA04009968A (es) 2002-04-09 2004-12-13 Flamel Tech Sa Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s).
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Also Published As

Publication number Publication date
PT1086694E (pt) 2006-12-29
EP1086694B1 (en) 2006-08-02
ES2269088T3 (es) 2007-04-01
KR100724201B1 (ko) 2007-05-31
US6780436B1 (en) 2004-08-24
CA2318008A1 (en) 2001-03-13
CA2318008C (en) 2010-08-17
EP1086694A3 (en) 2002-09-25
AU5791900A (en) 2001-03-15
AU777322B2 (en) 2004-10-14
DE60029712T2 (de) 2007-08-02
JP2001199878A (ja) 2001-07-24
CY1106219T1 (el) 2011-06-08
JP4885347B2 (ja) 2012-02-29
ES2168043A1 (es) 2002-05-16
EP1086694A2 (en) 2001-03-28
KR20020020974A (ko) 2002-03-18
DE60029712D1 (de) 2006-09-14
ATE334679T1 (de) 2006-08-15
DK1086694T3 (da) 2006-12-04

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