ES2168092T3 - Procedimientos de ensayo que utilizan la luminiscencia inducida. - Google Patents

Procedimientos de ensayo que utilizan la luminiscencia inducida.

Info

Publication number
ES2168092T3
ES2168092T3 ES92304630T ES92304630T ES2168092T3 ES 2168092 T3 ES2168092 T3 ES 2168092T3 ES 92304630 T ES92304630 T ES 92304630T ES 92304630 T ES92304630 T ES 92304630T ES 2168092 T3 ES2168092 T3 ES 2168092T3
Authority
ES
Spain
Prior art keywords
analyte
pacc
medium
sbp
luminiscence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92304630T
Other languages
English (en)
Inventor
Edwin F Ullman
Hrair Kirakossian
John S Pease
Daniel B Wagner
Yuri Daniloff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/704,569 external-priority patent/US6251581B1/en
Priority claimed from US07/718,490 external-priority patent/US5340716A/en
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Application granted granted Critical
Publication of ES2168092T3 publication Critical patent/ES2168092T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Luminescent Compositions (AREA)

Abstract

SE DESCRIBEN METODOS PARA LA DETERMINACION DE UNA ANALITA EN UN MEDIO QUE SE SOSPECHA CONTIENE LA ANALITA. UN METODO COMPRENDE EL TRATAMIENTO DE UN MEDIO QUE SE SOSPECHA CONTIENE UNA ANALITA BAJO CONDICIONES TALES QUE LA ANALITA; SI ESTA PRESENTE, HACE QUE UN FOTOSENSIBILIZADOR Y UN COMPUESTO QUIMICOLUMINISCENTE SE PONGAN EN CONTACTO. EL FOTOSENSIBILIZADOR GENERA OXIGENO DE SINGLETE Y ACTIVA EL COMPUESTO QUIMICOLUMINISCENTE CUANDO ESTA EN CONTACTO. POR CONSIGUIENTE LOS COMPUESTOS QUIMICOLUMINISCENTES ACTIVADOS PRODUCEN LUZ. LA CANTIDAD DE LUZ PRODUCIDA ESTA RELACIONADA CON LA CANTIDAD DE ANALITA EN EL MEDIO. PREFERIBLEMENTE, AL MENOS UN COMPUESTO DEL FOTOSENSIBILIZADOR Y EL QUIMICOLUMINISCENTE ESTA ASOCIADO A UNA SUPERFICIE QUE ES NORMALMENTE UNA PARTICULA SUSPENDIBLE, Y UN ELEMENTO DEL PAR DE FUSION ESPECIFICO ESTA LIMITADO A LA MISMA. OTRO METODO COMPRENDE EL PROPORCIONAR (1) UN MEDIO QUE SE SOSPECHA CONTIENE LA ANALITA, (2) UN REACTIVO DE ETIQUETA QUE COMPRENDE UN PRIMER ELEMENTO DEL PARDE FUSION ESPECIFICO (PFS) ASOCIADO A UN COMPUESTO QUIMICOLUMINISCENTE ACTIVABLE FOTOQUIMICAMENTE EN DONDE EL PRIMER ELEMENTO PFS ES CAPAZ DE FUNDIR LA PRIMERA ANALITA O UN SEGUNDO ELEMENTO PFS PARA FORMAR UN COMPLEJO RELACIONADO EN LA PRESENCIA DE LA ANALITA. ESTE METODO COMPRENDE ADEMAS LA ACTIVACION FOTOQUIMICAMENTE DEL COMPUESTO QUIMICOLUMINISCENTE. SE DETECTA LA CANTIDAD DE LUMINISCENCIA GENERADA POR EL COMPUESTO QUIMICOLUMINISCENTE. LA CANTIDAD DEL MISMO ESTA RELACIONADA CON LA CANTIDAD DE ANALITA EN EL MEDIO. TAMBIEN SE DESCRIBEN COMPOSICIONES Y APARATOS.
ES92304630T 1991-05-22 1992-05-21 Procedimientos de ensayo que utilizan la luminiscencia inducida. Expired - Lifetime ES2168092T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/704,569 US6251581B1 (en) 1991-05-22 1991-05-22 Assay method utilizing induced luminescence
US07/718,490 US5340716A (en) 1991-06-20 1991-06-20 Assay method utilizing photoactivated chemiluminescent label

Publications (1)

Publication Number Publication Date
ES2168092T3 true ES2168092T3 (es) 2002-06-01

Family

ID=27107346

Family Applications (3)

Application Number Title Priority Date Filing Date
ES99121551T Expired - Lifetime ES2204050T3 (es) 1991-05-22 1992-05-21 Particulas que tienen una composicion incorporada que comprende un compuesto quimioluminiscente.
ES92304630T Expired - Lifetime ES2168092T3 (es) 1991-05-22 1992-05-21 Procedimientos de ensayo que utilizan la luminiscencia inducida.
ES99121547T Expired - Lifetime ES2280110T3 (es) 1991-05-22 1992-05-21 Procedimiento para determinar un analito en una muestra.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES99121551T Expired - Lifetime ES2204050T3 (es) 1991-05-22 1992-05-21 Particulas que tienen una composicion incorporada que comprende un compuesto quimioluminiscente.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99121547T Expired - Lifetime ES2280110T3 (es) 1991-05-22 1992-05-21 Procedimiento para determinar un analito en una muestra.

Country Status (10)

Country Link
EP (4) EP0515194B1 (es)
JP (1) JP3892912B2 (es)
AT (3) ATE208039T1 (es)
AU (1) AU657134B2 (es)
CA (1) CA2069145C (es)
DE (3) DE69232161T2 (es)
DK (1) DK0984282T3 (es)
ES (3) ES2204050T3 (es)
IL (1) IL101945A (es)
PT (1) PT984282E (es)

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EP0984282B1 (en) 2003-07-30
DE69233674T2 (de) 2007-10-18
IL101945A (en) 1998-02-08
EP0984281B1 (en) 2007-01-03
ATE246360T1 (de) 2003-08-15
DE69233146D1 (de) 2003-09-04
EP1418430A2 (en) 2004-05-12
EP0515194B1 (en) 2001-10-31
ES2280110T3 (es) 2007-09-01
JPH05180773A (ja) 1993-07-23
EP1418430A3 (en) 2004-09-01
CA2069145C (en) 2007-07-31
JP3892912B2 (ja) 2007-03-14
DE69233146T2 (de) 2004-04-29
AU657134B2 (en) 1995-03-02
ES2204050T3 (es) 2004-04-16
EP0515194A3 (en) 1993-10-20
AU1706892A (en) 1992-11-26
EP0984282A3 (en) 2000-06-07
CA2069145A1 (en) 1992-11-23
ATE350665T1 (de) 2007-01-15
EP0515194A2 (en) 1992-11-25
DE69233674D1 (de) 2007-02-15
EP0984281A2 (en) 2000-03-08
DK0984282T3 (da) 2003-11-17
DE69232161D1 (de) 2001-12-06
IL101945A0 (en) 1992-12-30
EP0984282A2 (en) 2000-03-08
EP0984281A3 (en) 2000-06-07
DE69232161T2 (de) 2002-05-16
ATE208039T1 (de) 2001-11-15
PT984282E (pt) 2003-12-31

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