ES2168308T3 - Procedimientos para el control de la poblacion de celulas b. - Google Patents

Procedimientos para el control de la poblacion de celulas b.

Info

Publication number
ES2168308T3
ES2168308T3 ES94925178T ES94925178T ES2168308T3 ES 2168308 T3 ES2168308 T3 ES 2168308T3 ES 94925178 T ES94925178 T ES 94925178T ES 94925178 T ES94925178 T ES 94925178T ES 2168308 T3 ES2168308 T3 ES 2168308T3
Authority
ES
Spain
Prior art keywords
cells
marker
cell
death
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94925178T
Other languages
English (en)
Inventor
Neelima M Bhat
Marcia M Bieber
Nelson N H Teng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Application granted granted Critical
Publication of ES2168308T3 publication Critical patent/ES2168308T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE SUMINISTRAN METODOS PARA LA INDUCIR LA MUERTE EN LAS CELULAS DE LAS CELULAS B QUE INCLUYAN CELULAS B NEOPLASTICAS, EMPLEANDO REAGENTES QUE SE UNAN A UN EPITOPO DE LA CELULA B DESIGNADO EPITOPO CDIM. PARTICULARMENTE, PUEDEN ADMINISTRARSE ANTICUERPOS ESPECIFICOS PARA EL MARCADOR A LA CELULA B A UN ANFITRION PARA REDUCIR LA MUERTE EN LAS CELULAS B A LAS CUALES SE UNEN LOS ANTICUERPOS O PUEDEN USARSE EN SITUACIONES CLINICAS "EX VIVO" PARA ELIMINAR SELECTIVAMENTE LAS CELULAS B. HA SIDO IDENTIFICADO UN EPITOPO DE OLIGOSACARIDO ESPECIFICO PARA LAS CELULAS B UTIL COMO MARCADOR DE LAS CELULAS B. EL LIGANTE QUE SE RECONOCE SOBRE LOS LINFOCITOS B NO TIENE SIMILARIDADES APARENTES CON NINGUN ANTICUERPO MONOCLONAL HUMANO 216, QUE RECONOCE ESTE EPITOPO DE LAS CELULAS B Y SE UNE A TODOS LOS LINFOCITOS B CD19+ Y CD20+ EN LA SANGRE PERIFERICA HUMANA Y ES CITOTOXICO PARA LAS CELULAS B. ADEMAS, EL MAB 216 NO DISTINGUE LAS CELULAS B MEDIANTE EL ISOTIPO EXPRESADO, PONIENDOSE A LAS CELULAS IGM+ E IGG+ CON LA MISMA INTENSIDAD, Y TAMBIEN SE UNE A TODAS LAS CELULAS B A PESAR DE SU EXPRESION DE CD5. ESTOS PRODUCTOS Y METODOS ENCUENTRAN USO EN LOS CAMPOS DE LA DIAGNOSIS Y LA TERAPIA.
ES94925178T 1993-08-02 1994-08-02 Procedimientos para el control de la poblacion de celulas b. Expired - Lifetime ES2168308T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/101,436 US5417972A (en) 1993-08-02 1993-08-02 Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM

Publications (1)

Publication Number Publication Date
ES2168308T3 true ES2168308T3 (es) 2002-06-16

Family

ID=22284632

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94925178T Expired - Lifetime ES2168308T3 (es) 1993-08-02 1994-08-02 Procedimientos para el control de la poblacion de celulas b.

Country Status (10)

Country Link
US (2) US5417972A (es)
EP (1) EP0712307B1 (es)
AT (1) ATE208596T1 (es)
AU (1) AU7519794A (es)
DE (1) DE69429092T2 (es)
DK (1) DK0712307T3 (es)
ES (1) ES2168308T3 (es)
IL (1) IL110551A0 (es)
PT (1) PT712307E (es)
WO (1) WO1995003770A1 (es)

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US5417972A (en) * 1993-08-02 1995-05-23 The Board Of Trustees Of The Leland Stanford Junior University Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM

Also Published As

Publication number Publication date
DK0712307T3 (da) 2002-03-04
DE69429092D1 (de) 2001-12-20
AU7519794A (en) 1995-02-28
EP0712307A4 (en) 1998-10-21
EP0712307A1 (en) 1996-05-22
PT712307E (pt) 2002-05-31
WO1995003770A1 (en) 1995-02-09
US5593676A (en) 1997-01-14
US5417972A (en) 1995-05-23
EP0712307B1 (en) 2001-11-14
ATE208596T1 (de) 2001-11-15
DE69429092T2 (de) 2002-07-11
IL110551A0 (en) 1994-11-11

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