ES2169049T3 - Composiciones polimericas de mitoxantrona antitumorales. - Google Patents

Composiciones polimericas de mitoxantrona antitumorales.

Info

Publication number
ES2169049T3
ES2169049T3 ES94102401T ES94102401T ES2169049T3 ES 2169049 T3 ES2169049 T3 ES 2169049T3 ES 94102401 T ES94102401 T ES 94102401T ES 94102401 T ES94102401 T ES 94102401T ES 2169049 T3 ES2169049 T3 ES 2169049T3
Authority
ES
Spain
Prior art keywords
mitoxantrona
antitumor
polymeric compositions
antitumor polymeric
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94102401T
Other languages
English (en)
Inventor
Hwei-Ru Tsou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2169049T3 publication Critical patent/ES2169049T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE PRESENTA UNA COMPOSICION POLIMERICA ANTITUMORAL QUE COMPRENDE UN COMPUESTO ANTITUMORAL DE ANTRACENO, PARTICULARMENTE MITOXANTRONA, COVALENTEMENTE CONJUGADO, O ADMINISTRADO CON UN COPOLIMERO DE UN ANHIDRIDO ETER-MALEICO DE DIVINIL (MVE) ASI COMO METODOS PARA EL TRATAMIENTO DE TUMORES SOLIDOS Y LA INDUCCION DE LA REGRESION DEL CRECIMIENTO DE LAS CELULAS DE LA LEUCEMIA EN LOS MAMIFEROS MEDIANTE LA ADMINISTRACION DE DICHAS COMPOSICIONES.
ES94102401T 1993-03-25 1994-02-17 Composiciones polimericas de mitoxantrona antitumorales. Expired - Lifetime ES2169049T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/037,149 US5378456A (en) 1993-03-25 1993-03-25 Antitumor mitoxantrone polymeric compositions

Publications (1)

Publication Number Publication Date
ES2169049T3 true ES2169049T3 (es) 2002-07-01

Family

ID=21892713

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94102401T Expired - Lifetime ES2169049T3 (es) 1993-03-25 1994-02-17 Composiciones polimericas de mitoxantrona antitumorales.

Country Status (11)

Country Link
US (1) US5378456A (es)
EP (1) EP0616813B1 (es)
JP (1) JPH06321927A (es)
KR (1) KR100348380B1 (es)
AT (1) ATE210996T1 (es)
CA (1) CA2119675A1 (es)
DE (1) DE69429468T2 (es)
DK (1) DK0616813T3 (es)
ES (1) ES2169049T3 (es)
PT (1) PT616813E (es)
SG (1) SG52340A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
CA2472404A1 (en) * 1993-07-19 1995-02-02 Angiotech Pharmaceuticals, Inc. Combination of stent and anti-angiogenic factor
US5609867A (en) 1994-11-01 1997-03-11 American Cyanamid Company Polymeric antitumor agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
CA2424345A1 (en) * 2000-10-16 2002-04-25 Neopharm, Inc. Liposomal formulation of mitoxantrone
GB0123232D0 (en) * 2001-09-26 2001-11-21 Smith & Nephew Polymers
JP2010520852A (ja) * 2006-10-27 2010-06-17 ジュセッペ・トリジャンテ 除毛（脱毛）のための化合物と方法
CN112472699A (zh) 2013-07-26 2021-03-12 种族肿瘤学公司 改善比生群及衍生物的治疗益处的组合方法
CN115400083A (zh) * 2021-05-28 2022-11-29 石药集团中奇制药技术（石家庄）有限公司 盐酸米托蒽醌脂质体用于制备治疗晚期实体瘤的药物的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182800A (en) * 1977-07-16 1980-01-08 Hercules Incorporated Methotrexate-divinyl ether--maleic anhydride copolymer reaction product
JPS6067426A (ja) * 1983-09-24 1985-04-17 Agency Of Ind Science & Technol 低毒性制ガン剤
JPS6067490A (ja) * 1983-09-24 1985-04-17 Agency Of Ind Science & Technol アントラサイクリン系抗生物質誘導体及びその製造方法
US4520162A (en) * 1983-09-24 1985-05-28 Director-General Of The Agency Of Industrial Science & Technology Polymeric compounds with sustained anti-tumor activity and a method for the preparation thereof
GB8413464D0 (en) * 1984-05-25 1984-07-04 Erba Farmitalia Anthracycline-anionic polymer conjugates
DE3768419D1 (de) * 1986-10-07 1991-04-11 Boehringer Biochemia Srl Pharmazeutische zusammensetzungen mit antineoplastischer wirkung.
PT93772A (pt) * 1989-04-17 1991-01-08 Searle & Co Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer
JPH0762049B2 (ja) * 1991-03-18 1995-07-05 工業技術院長 高分子マイトマイシンｃ誘導体及びその製造方法
JP3069646B2 (ja) * 1991-05-28 2000-07-24 三共株式会社 ５−フルオロウリジン−高分子複合体

Also Published As

Publication number Publication date
KR100348380B1 (ko) 2004-03-25
SG52340A1 (en) 1998-09-28
EP0616813A2 (en) 1994-09-28
DK0616813T3 (da) 2002-04-15
PT616813E (pt) 2002-06-28
CA2119675A1 (en) 1994-09-26
US5378456A (en) 1995-01-03
EP0616813B1 (en) 2001-12-19
KR940021068A (ko) 1994-10-17
JPH06321927A (ja) 1994-11-22
EP0616813A3 (en) 1995-03-29
ATE210996T1 (de) 2002-01-15
DE69429468T2 (de) 2002-08-14
DE69429468D1 (de) 2002-01-31

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